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MLS000067308 (CID 2064400) - Compound BioActivity Data
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BioActivity Outcomes:
Active(32)
 
 
Inactive(681)
 
 
Inconclusive(34)
 
 
Unspecified(24)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
 
7TM GPCR Srsx(19)
 
 
 
ABCC CFTR1(17)
 
 
 
 
Chemokine CXC(16)
 
 
 
 
alkPPc(12)
 
 
BioAssay Types:
Screening(517)
 
 
 
 
 
Confirmatory(237)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(146)
 
 
 
 
 
IC50(73)
 
 
 
 
 
EC50(9)
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 680    Data Row: 771   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID16953363]
IC50_Mean 0.628Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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2
[SID144089005]
IC50_CF-PAF_Mean 4SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_8, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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3
[SID16953363]
AC50_uM 8.842HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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4
[SID16953363]
EC50 9.357High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor - Dose Response [AID1047, Type: confirmatory]
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5
[SID16953363]
EC50 13.507High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression - Dose Response [AID1045, Type: confirmatory]
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6
[SID16953363]
AC50_uM 18.141Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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7
[SID16953363]
Potency 22.3872qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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8
[SID16953363]
IC50 24.187Dose response confirmation of uHTS hits for small molecule modulators of myocardial damage [AID588779, Type: confirmatory]
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9
[SID16953363]
Potency 39.8107qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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10
[SID16953363]
Potency 50.1187qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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11
[SID144089005]
IC50_CF-PAF_Mean 66SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_15, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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12
[SID16953363]
uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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13
[SID16953363]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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14
[SID16953363]
Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1 [AID1304, Type: screening]neuropeptide Y receptor type 1 [Homo sapiens] [gi:4505445]
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15
[SID16953363]
Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y2 [AID1359, Type: screening]neuropeptide Y receptor type 2 [Homo sapiens] [gi:4505447]
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16
[SID16953363]
High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression [AID818, Type: screening]
View
17
[SID16953363]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
View
18
[SID16953363]
uHTS identification of small molecule modulators of myocardial damage [AID588492, Type: screening]
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19
[SID16953363]
High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor [AID827, Type: screening]
View
20
[SID16953363]
IC50_CF-PAF_Mean Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_4, Type: confirmatory]
View
21
[SID16953363]
Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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22
[SID16953363]
IC50_CF-PAF_Mean Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_1, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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23
[SID16953363]
Single concentration confirmation of uHTS hits for cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID602472, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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24
[SID16953363]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]BRCA1-associated RING domain protein 1 [gi:116241265]
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25
[SID16953363]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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26
[SID16953363]
uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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27
[SID16953363]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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28
[SID16953363]
CYP2C9 Assay [AID777, Type: screening]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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29
[SID16953363]
In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_Activity [AID504582, Type: screening]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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30
[SID16953363]
Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID504621, Type: screening]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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31
[SID16953363]
uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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32
[SID16953363]
Single concentration confirmation of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463218, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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33
[SID144089005]
IC50_CF-PAF_Mean 2.612SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_9, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
34
[SID144089005]
IC50_CF-PAF_Mean 3.299SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_10, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
35
[SID144089005]
IC50_CF-PAF_Mean 3.374SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_11, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
36
[SID144089005]
IC50_CF-PAF_Mean 4.492SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_12, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
37
[SID144089005]
IC50_CF-PAF_Mean 4.571SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_13, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
38
[SID144089005]
IC50_CF-PAF_Mean 5.681SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_14, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
39
[SID144089005]
IC50_CF-PAF_Mean 12.844SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_2, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
View
40
[SID144089005]
IC50_CF-PAF_Mean 13.024SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_6, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
View
41
[SID144089005]
IC50_CF-PAF_Mean 18.967SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_7, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
View
42
[SID144089005]
IC50_CF-PAF_Mean 20.074SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_3, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
View
43
[SID144089005]
IC50_CF-PAF_Mean 22.286SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_4, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
View
44
[SID144089005]
IC50_CF-PAF_Mean 66SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_5, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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45
[SID144089005]
IC50_CF-PAF_Mean 66SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_16, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
46
[SID144089005]
IC50_CF-PAF_Mean 66SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_17, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
47
[SID144089005]
IC50_CF-PAF_Mean 66SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_18, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
48
[SID144089005]
IC50_CF-PAF_Mean 66SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_19, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
49
[SID144089005]
IC50_CF-PAF_Mean 66SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_20, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
50
[SID144089005]
IC50_CF-PAF_Mean 66SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_21, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View