MLS000067308 (CID 2064400) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(30)
 
 
Inactive(589)
 
 
Inconclusive(30)
 
 
Unspecified(24)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
 
ABCC CFTR1(17)
 
 
 
 
Chemokine CXC(16)
 
 
 
 
alkPPc(12)
 
 
Bcl-2 like(10)
 
 
BioAssay Types:
Screening(445)
 
 
 
 
 
Confirmatory(212)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(126)
 
 
 
 
 
IC50(69)
 
 
 
 
 
EC50(9)
 
 
 
AC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 646    Data Row: 673   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID16953363]
IC50 0.628Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
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2
[SID16953363]
IC50 0.628Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
3
[SID16953363]
IC50 0.628Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
4
[SID144089005]
IC50 4SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_8, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
5
[SID144089005]
IC50 4SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_8, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
6
[SID16953363]
AC50 8.842HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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7
[SID16953363]
AC50 8.842HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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8
[SID16953363]
AC50 8.842HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
View
9
[SID16953363]
EC50 9.357High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor - Dose Response [AID1047, Type: confirmatory]
View
10
[SID16953363]
EC50 13.507High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression - Dose Response [AID1045, Type: confirmatory]
View
11
[SID16953363]
AC50 18.141Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
View
12
[SID16953363]
Potency 22.3872qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
View
13
[SID16953363]
IC50 24.187Dose response confirmation of uHTS hits for small molecule modulators of myocardial damage [AID588779, Type: confirmatory]
View
14
[SID16953363]
Potency 39.8107qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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15
[SID16953363]
Potency 50.1187qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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16
[SID144089005]
IC50 66SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_15, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
17
[SID144089005]
IC50 66SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_15, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
18
[SID16953363]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
View
19
[SID16953363]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
View
20
[SID16953363]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_1, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
21
[SID16953363]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_1, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
22
[SID16953363]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
View
23
[SID16953363]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
View
24
[SID16953363]
 uHTS identification of small molecule modulators of myocardial damage [AID588492, Type: screening]
View
25
[SID16953363]
 High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor [AID827, Type: screening]
View
26
[SID16953363]
 High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression [AID818, Type: screening]
View
27
[SID16953363]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
View
28
[SID16953363]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
View
29
[SID16953363]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
View
30
[SID16953363]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
View
31
[SID16953363]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
View
32
[SID16953363]
 Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1 [AID1304, Type: screening]neuropeptide Y receptor Y1 [Homo sapiens] [gi:4505445]
View
33
[SID16953363]
 Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1 [AID1304, Type: screening]neuropeptide Y receptor Y1 [Homo sapiens] [gi:4505445]
View
34
[SID16953363]
 Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y2 [AID1359, Type: screening]neuropeptide Y receptor Y2 [Homo sapiens] [gi:4505447]
View
35
[SID16953363]
 Primary cell-based high-throughput screening assay for potentiators or agonists of NPY-Y2 [AID1359, Type: screening]neuropeptide Y receptor Y2 [Homo sapiens] [gi:4505447]
View
36
[SID16953363]
 CYP2C9 Assay [AID777, Type: screening]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
View
37
[SID16953363]
 CYP2C9 Assay [AID777, Type: screening]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
View
38
[SID16953363]
 CYP2C9 Assay [AID777, Type: screening]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
View
39
[SID16953363]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_4, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
40
[SID16953363]
IC50 Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_4, Type: confirmatory]CFTR gene product [Homo sapiens] [gi:90421313]
View
41
[SID16953363]
 Single concentration confirmation of uHTS hits for cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID602472, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
View
42
[SID16953363]
 Single concentration confirmation of uHTS hits for cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID602472, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
View
43
[SID16953363]
 uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
View
44
[SID16953363]
 uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
View
45
[SID16953363]
 In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_Activity [AID504582, Type: screening]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
View
46
[SID16953363]
 Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID504621, Type: screening]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
View
47
[SID16953363]
 uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
View
48
[SID16953363]
 Single concentration confirmation of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463218, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
View
49
[SID144089005]
IC50 2.612SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_9, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View
50
[SID144089005]
IC50 2.612SAR analysis of molecule cystic fibrosis induced NFkb Inhibitors in a panel assay [AID651592_9, Type: confirmatory]IL8 gene product [Homo sapiens] [gi:10834978]
View