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AC1M0YGG (CID 2059132) - Compound BioActivity Data
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BioActivity Outcomes:
Active(101)
 
 
Inactive(557)
 
 
Inconclusive(50)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
 
Bcl-2 like(15)
 
 
 
 
7TM GPCR Srsx(14)
 
 
 
alkPPc(10)
 
 
KCNQ channel(8)
 
 
BioAssay Types:
Screening(443)
 
 
 
 
Confirmatory(231)
 
 
 
 
 
Literature(7)
 
 
BioActivity Types:
Potency(156)
 
 
 
 
 
IC50(40)
 
 
 
 
EC50(16)
 
 
 
 
AC50(10)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 647    Data Row: 709   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24781837]
Potency 0.1585Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504848, Type: confirmatory]
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2
[SID24781837]
Absolute IC50 (CHOP) 0.3CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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3
[SID24781837]
Potency 0.3162Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504850, Type: confirmatory]
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4
[SID24781837]
Potency 0.4109A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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5
[SID24781837]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID24781837]
Absolute IC50 (XBP1) 0.55XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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7
[SID24781837]
AC50_uM 0.5793Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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8
[SID24781837]
Potency 0.5848qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox [AID588382, Type: confirmatory]
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9
[SID24781837]
Potency 0.6513qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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10
[SID24781837]
AC50_uM 0.6717ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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11
[SID24781837]
Potency 0.7308qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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12
[SID24781837]
Potency 0.8913qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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13
[SID24781837]
Potency 0.8913qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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14
[SID24781837]
Potency 0.92qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID24781837]
Potency 0.9952qHTS Assay for Inhibitors of Hepatitis C Virus (HCV): Confirmation Assay for Cherry-picked Compounds [AID720575, Type: confirmatory]hepatitis C virus polyprotein [Hepatitis C virus] [gi:295901482]
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16
[SID24781837]
Potency 1.0323qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Beta-Lactamase Assay [AID602202, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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17
[SID24781837]
Potency 1.4058qHTS Assay for Inhibitors of Hepatitis C Virus (HCV): Cytotoxicity Counterscreen for Cherry-picked Compounds [AID720576, Type: confirmatory]
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18
[SID24781837]
Potency 1.7783qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
View
19
[SID24781837]
Potency 1.9953qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay [AID602200, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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20
[SID24781837]
Potency 1.9953qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]neuropeptide S receptor isoform A [Homo sapiens] [gi:46395496]
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21
[SID24781837]
Potency 2.0787Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
View
22
[SID24781837]
Potency 2.5119qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen [AID602199, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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23
[SID24781837]
Potency 3.1623qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Texas Red Assay [AID602201, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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24
[SID24781837]
Potency 5.6234qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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25
[SID24781837]
Potency 5.8048Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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26
[SID24781837]
Potency 5.8048Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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27
[SID24781837]
Potency 6.4972qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
View
28
[SID24781837]
AC50_uM 7.804HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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29
[SID24781837]
AC50_uM 8.258Luminescence Cell-Based Counterscreen to Identify Inhibitors of A1 Apoptosis (Bax-Bak knockout) [AID449754, Type: confirmatory]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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30
[SID24781837]
AC50_uM 8.291Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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31
[SID24781837]
EC50_uM 8.462Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis [AID2765, Type: confirmatory]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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32
[SID24781837]
EC50_uM 8.462Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis [AID2765, Type: confirmatory]bcl-2-like protein 11 isoform 1 [Homo sapiens] [gi:20336315]
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33
[SID24781837]
Potency 11.2202qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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34
[SID24781837]
Potency 11.9173qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Cytotoxicity Assay [AID602204, Type: confirmatory]
View
35
[SID24781837]
Potency 17.7828qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
View
36
[SID24781837]
Potency 35.4813qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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37
[SID24781837]
AC50_uM 48Luminescence Cell-Based Secondary Screen to Identify Inhibitors of A1(alternate construct) [AID449757, Type: confirmatory]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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38
[SID24781837]
AC50_uM 48Luminescence Cell-Based Secondary Screen to Identify Inhibitors of A1(alternate construct) [AID449757, Type: confirmatory]Bcl-2-like protein 11 [gi:18202042]
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39
[SID24781837]
AC50_uM 48.22Luminescence Cell-Based Counterscreen to Identify Inhibitors of A1 Apoptosis (non-primed) [AID449761, Type: confirmatory]
View
40
[SID24781837]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
View
41
[SID24781837]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504539, Type: confirmatory]
View
42
[SID24781837]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_CherryPick_Activity [AID504592, Type: confirmatory]
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43
[SID24781837]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
View
44
[SID24781837]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Counterscreen with HEK cells [AID1716, Type: other]
View
45
[SID24781837]
uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
View
46
[SID24781837]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
View
47
[SID24781837]
uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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48
[SID24781837]
Leishmania major promastigote HTS [AID1063, Type: screening]
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49
[SID24781837]
Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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50
[SID24781837]
HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules. [AID1381, Type: screening]
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