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BioActivity Data for Compound MLS000551821 (CID 2041056)

BioActivity Outcomes:
Active(46)
 
 
Inactive(644)
 
 
Inconclusive(41)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(44)
 
 
Bcl-2 like(13)
 
 
 
alkPPc(10)
 
 
Tryp SPc(9)
 
 
 
G-alpha(8)
 
 
BioAssay Types:
Screening(481)
 
 
 
 
Confirmatory(223)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(152)
 
 
 
 
 
IC50(45)
 
 
 
 
EC50(12)
 
 
 
AC50(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 660    Data Row: 732   Total Pages: 37   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14730712]
Average IC50 1.36High Throughput Screen to Identify Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G:#A time-resolved fluorescence resonance energy transfer (TR-FRET) assay for HIV-1 Vif-APOBEC3G interaction [AID1117319, Type: confirmatory]Vif [Human immunodeficiency virus 1] [gi:9629361]
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2
[SID14730712]
Average IC50 1.36High Throughput Screen to Identify Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G:#A time-resolved fluorescence resonance energy transfer (TR-FRET) assay for HIV-1 Vif-APOBEC3G interaction [AID1117319, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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3
[SID14730712]
Absolute IC50 1.93Dose Response Confirmation for Small Molecule Inhibitors of Epstein-Barr Virus [AID1419, Type: confirmatory]BZLF2 [Human herpesvirus 4 type 2] [gi:139424501]
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4
[SID14730712]
EC50_MICROM 6.07Dose response compound fluorescence counter screen for HTS for inhibitors of efflux pump with Hit compounds from Cherry Pick1 [AID588620, Type: confirmatory]
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5
[SID124360076]
AC50_uM 8.54C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_DryPowder_Activity [AID588363, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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6
[SID14730712]
EC50_MICROM 9.63Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Mdr1 with Hit compounds from Cherry Pick1 [AID588608, Type: confirmatory]
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7
[SID14730712]
AC50_uM 10.01Luminescence Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of GSK-3 alpha [AID463203, Type: confirmatory]glycogen synthase kinase-3 alpha [Homo sapiens] [gi:49574532]
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8
[SID14730712]
AC50_uM 14.474C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity [AID504725, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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9
[SID14730712]
EC50_MICROM 18.4Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Cdr2 with Hit compounds from Cherry Pick1 [AID588604, Type: confirmatory]drug resistance protein 2 [Candida albicans] [gi:93115982]
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10
[SID14730712]
AC50_uM 18.937C-LANA Counter Screen: DNA intercalators Measured in Biochemical System Using Plate Reader - 2117-02_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504727, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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11
[SID14730712]
Potency 19.9526qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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12
[SID14730712]
Potency 22.3872qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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13
[SID124360076]
AC50_uM 29.99C-LANA Counter Screen: DNA intercalators Measured in Biochemical System Using Plate Reader - 2117-02_Inhibitor_Dose_DryPowder_Activity [AID588364, Type: confirmatory]
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14
[SID14730712]
Potency 31.6228Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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15
[SID14730712]
Potency 32.609qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation [AID651600, Type: confirmatory]tumor susceptibility gene 101 protein [Homo sapiens] [gi:5454140]
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16
[SID14730712]
Potency 79.4328qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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17
[SID14730712]
IC50 uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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18
[SID14730712]
uHTS HTRF interference counterscreen assay for validation of inhibitors of SUMOylation [AID2069, Type: screening]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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19
[SID14730712]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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20
[SID14730712]
Counterscreen for inhibitors of LEDGF/p75-dependent integration: TR-FRET-based biochemical high throughput counterscreen assay to identify activators of HIV-1 Integrase multimerization [AID1053131, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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