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MLS000551821 (CID 2041056) - Compound BioActivity Data
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BioActivity Outcomes:
Active(40)
 
 
Inactive(633)
 
 
Inconclusive(41)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(20)
 
 
Bcl-2 like(13)
 
 
 
alkPPc(10)
 
 
Tryp SPc(9)
 
 
 
BioAssay Types:
Screening(473)
 
 
 
 
Confirmatory(220)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(152)
 
 
 
 
 
IC50(43)
 
 
 
 
EC50(12)
 
 
 
AC50(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 652    Data Row: 715   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14730712]
Absolute IC50 1.93Dose Response Confirmation for Small Molecule Inhibitors of Epstein-Barr Virus [AID1419, Type: confirmatory]BZLF2 [Human herpesvirus 4 type 2] [gi:139424501]
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2
[SID14730712]
EC50_MICROM 6.07Dose response compound fluorescence counter screen for HTS for inhibitors of efflux pump with Hit compounds from Cherry Pick1 [AID588620, Type: confirmatory]
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3
[SID124360076]
AC50_uM 8.54C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_DryPowder_Activity [AID588363, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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4
[SID14730712]
EC50_MICROM 9.63Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Mdr1 with Hit compounds from Cherry Pick1 [AID588608, Type: confirmatory]
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5
[SID14730712]
AC50_uM 10.01Luminescence Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of GSK-3 alpha [AID463203, Type: confirmatory]glycogen synthase kinase-3 alpha [Homo sapiens] [gi:49574532]
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6
[SID14730712]
AC50_uM 14.474C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity [AID504725, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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7
[SID14730712]
EC50_MICROM 18.4Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Cdr2 with Hit compounds from Cherry Pick1 [AID588604, Type: confirmatory]drug resistance protein 2 [Candida albicans] [gi:93115982]
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8
[SID14730712]
AC50_uM 18.937C-LANA Counter Screen: DNA intercalators Measured in Biochemical System Using Plate Reader - 2117-02_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504727, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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9
[SID14730712]
Potency 19.9526qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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10
[SID14730712]
Potency 22.3872qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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11
[SID124360076]
AC50_uM 29.99C-LANA Counter Screen: DNA intercalators Measured in Biochemical System Using Plate Reader - 2117-02_Inhibitor_Dose_DryPowder_Activity [AID588364, Type: confirmatory]
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12
[SID14730712]
Potency 31.6228Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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13
[SID14730712]
Potency 32.609qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation [AID651600, Type: confirmatory]tumor susceptibility gene 101 protein [Homo sapiens] [gi:5454140]
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14
[SID14730712]
Potency 79.4328qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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15
[SID14730712]
IC50 uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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16
[SID14730712]
uHTS HTRF interference counterscreen assay for validation of inhibitors of SUMOylation [AID2069, Type: screening]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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17
[SID14730712]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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18
[SID14730712]
uHTS HTRF interference counterscreen assay for validation of inhibitors of SUMOylation [AID2069, Type: screening]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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19
[SID14730712]
uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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20
[SID14730712]
IC50 uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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21
[SID14730712]
Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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22
[SID14730712]
Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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23
[SID14730712]
Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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24
[SID14730712]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase [Human immunodeficiency virus 1] [gi:2853980]
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25
[SID14730712]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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26
[SID14730712]
IC50 uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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27
[SID14730712]
uHTS HTRF interference counterscreen assay for validation of inhibitors of SUMOylation [AID2069, Type: screening]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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28
[SID14730712]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of GLD-1 protein - TGE RNA interaction. [AID2280, Type: screening]Protein GLD-1 [Caenorhabditis elegans] [gi:17507875]
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29
[SID14730712]
Counterscreen for MCL1 inhibitors: fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2166, Type: screening]bcl-2-like protein 1 isoform 1 [Homo sapiens] [gi:20336335]
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30
[SID14730712]
Fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID687036, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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31
[SID14730712]
Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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32
[SID14730712]
uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assay [AID651999, Type: screening]COP9 signalosome complex subunit 5 [Homo sapiens] [gi:38027923]
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33
[SID14730712]
Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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34
[SID14730712]
Fluorescence Intensity-based biochemical primary high throughput confirmation assay to identify activators of kallikrein-7 (K7) zymogen [AID686949, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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35
[SID14730712]
IC50 uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. [AID1986, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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36
[SID14730712]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2057, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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37
[SID14730712]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2168, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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38
[SID14730712]
uHTS for Small Molecule Inhibitiors of Epstein-Barr Virus Inhibitors [AID1085, Type: screening]BZLF2 [Human herpesvirus 4 type 2] [gi:139424501]
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39
[SID14730712]
C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_SinglePoint_HTS_Activity [AID504423, Type: screening]LANA [Human herpesvirus 8] [gi:312275222]
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40
[SID14730712]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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41
[SID14730712]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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42
[SID14730712]
Potency 11.2202qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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43
[SID14730712]
Potency 22.3872qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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44
[SID14730712]
Potency 23.7781qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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45
[SID14730712]
Potency 31.6228qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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46
[SID14730712]
Potency 35.4813qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720709, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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47
[SID14730712]
Potency 79.4328qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen [AID720708, Type: confirmatory]Rap guanine nucleotide exchange factor 4 [gi:32171491]
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48
[SID14730712]
Potency 112.202qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen [AID720711, Type: confirmatory]Rap guanine nucleotide exchange factor 4 [gi:32171491]
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49
[SID14730712]
AC50_uM 300Luminescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of ADP-glo [AID463205, Type: confirmatory]
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50
[SID14730712]
Counterscreen of compound fluorescence effects on High-throughput multiplex microsphere screening for inhibitors of toxin protease [AID624483, Type: screening]
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