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Allantoin (CID 204) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(1032)
 
 
Inconclusive(61)
 
 
Unspecified(18)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
NR LBD PPAR(24)
 
 
 
NR LBD ER(21)
 
 
 
NR LBD AR(21)
 
 
 
 
7TM GPCR Srsx(19)
 
 
BioAssay Types:
Confirmatory(522)
 
 
 
 
 
Screening(433)
 
 
 
Summary(72)
 
 
 
Literature(16)
 
 
 
BioActivity Types:
Potency(463)
 
 
 
 
 
IC50(39)
 
 
EC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 801    Data Row: 1114   Total Pages: 23   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144203946]
Potency-Replicate_1 11.3588qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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2
[SID26748398]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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3
[SID26748398]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 [Homo sapiens] [gi:33946324]
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4
[SID8149886]
Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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5
[SID8149886]
Screen for compounds that inhibit polyglutamine induced protein aggregation (AGREG) [AID1604, Type: other]
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6
[SID8149886]
Screening of compounds showing protective effect against cell death induced by familial amyotrophic lateral sclerosis (FALS)-linked mutantsuperoxide dismutase 1 (SOD1) (ALSOD1) [AID1605, Type: other]
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7
[SID103717446]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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8
[SID103717446]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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9
[SID103717446]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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10
[SID103717446]
Induction of NGF production in rat C6 cells at 20 uM after 24 hrs by ELISA relative to untreated control [AID589667, Type: Literature]
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11
[SID103717446]
Cytotoxicity against rat C6 cells assessed as viable cells at 20 uM after 24 hrs by MTT assay [AID589668, Type: Literature]
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12
[SID8149886]
Screen for compounds that induce the human heat shock transcriptional response (HSEluc) [AID1611, Type: other]
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13
[SID8149886]
Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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14
[SID8149886]
Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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15
[SID8149886]
Screen for compounds that reduce polyglutamine (polyQ) inclusions in nerve growth factor (NGF)-treated PC12 cells (GFPQ80) [AID1614, Type: other]
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16
[SID8149886]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubH) [AID1616, Type: other]
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17
[SID8149886]
Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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18
[SID8149886]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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19
[SID8149886]
Screen for compounds that correct neuronal dysfunction without cell death as induced by the expression of polyglutamine-expanded, N-terminal huntingtin in C. elegans mechanosensory neurons (HDELENEU) [AID1599, Type: other]
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20
[SID26665884]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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21
[SID26748398]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
22
[SID26665884]
Potency 7.0795qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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23
[SID144203946]
Potency-Replicate_1 12.7448qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
24
[SID144203946]
Potency-Replicate_1 14.2999qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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25
[SID144213229]
Potency-Replicate_1 15.3553qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
View
26
[SID144213229]
Potency-Replicate_1 34.6654qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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27
[SID144209285]
Potency-Replicate_1 54.3903qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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28
[SID144209285]
Potency-Replicate_1 60.5094qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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29
[SID144209285]
Potency-Replicate_1 76.1769qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
30
[SID144209285]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
31
[SID144209285]
AR Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
32
[SID144209285]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
33
[SID144213229]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
View
34
[SID144209285]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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35
[SID144209285]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
View
36
[SID144203946]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
View
37
[SID144203946]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743094, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
View
38
[SID144209285]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway [AID743222, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
View
39
[SID144209285]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway [AID743223, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
View
40
[SID144209285]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway: Summary [AID743241, Type: summary]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
View
41
[SID144209285]
qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway: Summary [AID743242, Type: summary]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
View
42
[SID144213229]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway: Summary [AID743241, Type: summary]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
View
43
[SID144213229]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
44
[SID144213229]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
45
[SID144213229]
AR Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
46
[SID144213229]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
47
[SID144213229]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
48
[SID144203946]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
49
[SID144203946]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
50
[SID144203946]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View