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alpha-Tocopherol (CID 20353) - Compound BioActivity Data
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BioActivity Outcomes:
Active(25)
 
 
Inactive(207)
 
 
Inconclusive(45)
 
 
Unspecified(49)
 
 
Top Targets:
NR LBD AR(14)
 
 
 
NR LBD ER(14)
 
 
 
NR LBD PPAR(10)
 
 
 
NR LBD GR(8)
 
 
 
NR LBD TR(6)
 
 
 
BioAssay Types:
Confirmatory(142)
 
 
 
 
 
Literature(96)
 
 
 
 
 
Summary(39)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(170)
 
 
 
 
IC50(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 204    Data Row: 326   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103283478]
IC50 10Inhibition of mouse 4T1 cells adhesion to gelatinous matrix protein-coated surface after 60 mins by ELISA [AID448010, Type: Literature]
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2
[SID50112815]
Potency 11.9955Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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3
[SID144206109]
Potency-Replicate_1 23.7101qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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4
[SID144206109]
Potency-Replicate_1 26.8325qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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5
[SID50112815]
Potency 35.4813Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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6
[SID103283478]
IC50 42Inhibition of bovine mitochondrial electron transport protein complex 2 succinate:DCPIP oxidoreductase activity by spectrophotometry [AID1064575, Type: Literature]
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7
[SID103283478]
Drug degradation in denaturated rat liver homogenates assessed as compound recovery at 500 nmol after 4 hrs by HPLC analysis [AID1064558, Type: Literature]
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8
[SID103283478]
Cytotoxicity against mouse N18TG2 cells at 6.25 to 100 uM by MTT assay [AID1064577, Type: Literature]
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9
[SID103283478]
Antiangiogenic activity against Homo sapiens (human) HepG2 cells assessed as reduction in VEGF level at 55 uM from 24 to 48 hr by ELISA relative to control [AID1085780, Type: other]
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10
[SID103283478]
Cytotoxicity against Homo sapiens (human) HepG2 cells assessed as DNA fragmentation at 55 uM from 24 to 48 hr by agarose gel electrophoresis [AID1085783, Type: other]
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11
[SID103283478]
Cytotoxicity against Homo sapiens (human) HCT116 cells assessed as DNA fragmentation at 53.2 uM after 48 hr by agarose gel electrophoresis [AID1085784, Type: other]
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12
[SID103283478]
Induction of apoptosis in Homo sapiens (human) HepG2 cells assessed as caspase9 cleavage at 55 uM at 16 hr by Western blot analysis [AID1085785, Type: other]
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13
[SID103283478]
Induction of apoptosis in Homo sapiens (human) HCT116 cells assessed as caspase9 cleavage at 52.3 uM at 16 hr by Western blot analysis [AID1085786, Type: other]
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14
[SID103283478]
Induction of superoxide radical generation in mouse N18TG2 cells assessed as CMH oxidation at 200 uM after 2 hrs by ESR spectroscopy relative to control [AID1064560, Type: Literature]
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15
[SID103283478]
Induction of superoxide radical generation in bovine succinate-respiring submitochondrial particles assessed as oxidation of CPH at 900 uM after 2 mins by ESR spectroscopy in presence of rotenone [AID1064561, Type: Literature]
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16
[SID103283478]
Induction of superoxide radical generation in bovine succinate-respiring submitochondrial particles assessed as oxidation of CPH at 900 uM after 2 mins by ESR spectroscopy [AID1064565, Type: Literature]
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17
[SID103283478]
Induction of superoxide radical generation in bovine NADH-respiring submitochondrial particles assessed as oxidation of CPH at 900 uM after 2 mins by ESR spectroscopy [AID1064566, Type: Literature]
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18
[SID103283478]
Induction of superoxide radical generation in bovine succinate-respiring submitochondrial particles assessed as oxidation of CPH after 2 mins by ESR spectroscopy relative to control [AID1064570, Type: Literature]
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19
[SID103283478]
Induction of superoxide radical generation in bovine NADH-respiring submitochondrial particles assessed as oxidation of CPH after 2 mins by ESR spectroscopy relative to control [AID1064571, Type: Literature]
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20
[SID103283478]
Inhibition of mouse 4T1 cells adhesion to collagen 4 at 5 to 100 uM after 60 mins by ELISA [AID448615, Type: Literature]
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