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BioActivity Data for Compound nitroxoline (CID 19910)

BioActivity Outcomes:
Active(194)
 
 
Inactive(782)
 
 
Inconclusive(128)
 
 
Unspecified(17)
 
 
Top Targets:
7tm 4(49)
 
 
 
 
NR LBD PPAR(14)
 
 
 
 
Bcl-2 like(11)
 
 
 
alkPPc(10)
 
 
KCNQ channel(10)
 
 
 
BioAssay Types:
Screening(581)
 
 
 
 
Confirmatory(373)
 
 
 
 
 
Literature(108)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(269)
 
 
 
 
 
IC50(71)
 
 
 
 
 
EC50(33)
 
 
 
 
AC50(13)
 
 
 
Ki(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 913    Data Row: 1121   Total Pages: 57   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124971549]
IC50 0.055Inhibition of human methionine aminopeptidase 2 [AID760045, Type: Literature]Methionine aminopeptidase 2 [gi:1703273]
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2
[SID124971549]
IC50 0.06Inhibition of Burkholderia pseudomallei recombinant methionine aminopeptidase 1 using H-Met-Gly-Pro-7-amino-4-methylcoumarin hydrochloride as substrate measured for 10 mins by fluorescence assay in presence of human recombinant DPP4 [AID760047, Type: Literature]
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3
[SID11532939]
EC50 0.161Fluorescence Cell-Based Retest of C. albicans Growth in the Presence of Fluconazole [AID2467, Type: confirmatory]
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4
[SID170466124]
Ratio Potency (uM) 0.195689qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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5
[SID29216358]
Potency 0.2818qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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6
[SID170466124]
IC50 0.2952Decreased HeLa cell count-IC50 [AID1117347, Type: confirmatory]
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7
[SID170466124]
IC50 0.37509GSK3B-pretreated HCT116 viability from Cell TiterGlo-IC50 [AID1117339, Type: confirmatory]
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8
[SID11532939]
Potency 0.4467VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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9
[SID29216358]
Potency 0.5623VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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10
[SID170466124]
IC50 0.60458SW480 viability from Cell TiterGlo-IC50 [AID1117338, Type: confirmatory]
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11
[SID11532939]
EC50_MICROM 0.607Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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12
[SID11532939]
EC50 0.681Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole [AID2423, Type: confirmatory]heat shock protein 90 [Candida albicans] [gi:994798]
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13
[SID170466124]
IC50 0.68366Colo320 viability from Cell TiterGlo-IC50 [AID1117334, Type: confirmatory]
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14
[SID11532939]
Potency 0.7079qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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15
[SID170466124]
IC50 0.71008RKO viability from Cell TiterGlo-IC50 [AID1117322, Type: confirmatory]
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16
[SID56423111]
EC50_MICROM 0.752Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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17
[SID11532939]
IC50 0.79A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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18
[SID170466124]
IC50 0.92057HCT116 viability from Cell TiterGlo-IC50 [AID1117332, Type: confirmatory]
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19
[SID11532939]
IC50 0.96A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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20
[SID11532939]
AC50_uM 0.996HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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