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Acetaminophen (CID 1983) - Compound BioActivity Data
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BioActivity Outcomes:
Active(69)
 
 
Inactive(1261)
 
 
Inconclusive(82)
 
 
Unspecified(2049)
 
 
Top Targets:
p450(43)
 
 
 
 
 
7TM GPCR Srx(36)
 
 
 
NR LBD PPAR(34)
 
 
 
7TM GPCR Srsx(33)
 
 
 
NR LBD ER(27)
 
 
 
 
BioAssay Types:
Confirmatory(887)
 
 
 
 
 
Literature(491)
 
 
 
 
 
Screening(315)
 
 
 
Summary(72)
 
 
 
BioActivity Types:
Potency(722)
 
 
 
 
IC50(159)
 
 
 
 
 
Ki(18)
 
 
 
Kd(3)
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2867    Data Row: 3461   Total Pages: 174   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103178971]
IC50 2.3Inhibition of myoglobin (unknown origin)-mediated arachidonic acid oxidation using [14C]AA as substrate after 3 hrs by GC/NICI/MS analysis [AID760171, Type: Literature]Myoglobin [gi:127661]
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2
[SID103178971]
Ki 4.1Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay [AID342484, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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3
[SID103178971]
Kd 5.79Binding affinity to human CYP1A1-heme complex [AID536418, Type: Literature]
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4
[SID103178971]
Ki 6.2Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay [AID331292, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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5
[SID103178971]
Ki 6.2Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay [AID342476, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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6
[SID103178971]
Kd 6.64Binding affinity to rat CYP2B1-heme complex [AID536419, Type: Literature]
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7
[SID103178971]
Ki 7.1Inhibition of human carbonic anhydrase 3 by stopped-flow CO2 hydration assay [AID342477, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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8
[SID103178971]
Ki 9.1Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay [AID342482, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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9
[SID103178971]
Ki 9.23Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay [AID331293, Type: Literature]Carbonic anhydrase 15 [gi:30580362]
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10
[SID103178971]
Ki 10Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay [AID331291, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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11
[SID103178971]
Ki 10Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay [AID342475, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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12
[SID103178971]
Ki 10.6Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay [AID342485, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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13
[SID103178971]
Ki 11.4Inhibition of human carbonic anhydrase 4 by stopped-flow CO2 hydration assay [AID342478, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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14
[SID56422763]
AC50_uM 14.53C. difficile toxins: Counterscreen in absence of substrate UDPG Measured in Biochemical System Using Plate Reader - 7074-02_Inhibitor_Dose_CherryPick_Activity [AID720650, Type: confirmatory]
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15
[SID103178971]
Kd 19.1Binding affinity to human CYP1A1 [AID536416, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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16
[SID56422763]
AC50_uM 20.87C. difficile toxins: HTS for inhibitors of TcdB glycohydrolase activity Measured in Biochemical System Using Plate Reader - 7074-01_Inhibitor_Dose_CherryPick_Activity [AID720512, Type: confirmatory]toxin B [Peptoclostridium difficile 630] [gi:126698238]
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17
[SID103178971]
IC50 28.38DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: confirmatory]Arachidonate 15-lipoxygenase [gi:126397]
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18
[SID103178971]
Ki 30.3Inhibition of mouse carbonic anhydrase 13 by stopped-flow CO2 hydration assay [AID342486, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
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19
[SID103178971]
IC50 44Inhibition of FLAP [AID405531, Type: Literature]
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20
[SID103178971]
IC50 44Inhibition of LPS-stimulated PGE2 production in human whole blood [AID405541, Type: Literature]
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