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1-ethyl-6-fluoro-4-oxo-7-(4-{[2-(trifluoromethyl)phenyl]carbamothioyl}piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (CID 1960382) - Compound BioActivity Data
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BioActivity Outcomes:
Active(14)
 
 
Inactive(2)
 
 
Top Targets:
PDDEXK 1(3)
 
 
recC(3)
 
 
COG3893(2)
 
 
AAA 19(2)
 
 
BioAssay Types:
Confirmatory(12)
 
 
 
BioActivity Types:
IC50(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 11    Data Row: 16   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID92093432]
IC50 3.79A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium (2) using purified and synthesized compounds [AID2831, Type: confirmatory]
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2
[SID126920298]
IC50 20Late stage assay provider counterscreen for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the helicase/Chi cutting activity of purified RecBCD [AID623942, Type: confirmatory]exonuclease V (RecBCD complex), gamma chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130726]
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3
[SID126920298]
IC50 20Late stage assay provider counterscreen for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the helicase/Chi cutting activity of purified RecBCD [AID623942, Type: confirmatory]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
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4
[SID92093432]
IC50 24.06A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi (2) using purified and synthesized compounds [AID2839, Type: confirmatory]
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5
[SID126920298]
IC50 40Late stage assay provider counterscreen for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the nuclease activity of purified RecBCD enzyme [AID623920, Type: confirmatory]exonuclease V (RecBCD complex), gamma chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130726]
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6
[SID126920298]
IC50 40Late stage assay provider counterscreen for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the nuclease activity of purified RecBCD enzyme [AID623920, Type: confirmatory]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
View
7
[SID92093432]
IC50 76.43A counter screen for small molecule inhibitors of the PhoP regulon in Salmonella Typhimurium (2) using purified and synthesized compounds [AID2834, Type: confirmatory]
View
8
[SID126920298]
IC50 79Late stage assay provider assay for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the nuclease activity of purified AddAB [AID602421, Type: confirmatory]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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9
[SID126920298]
IC50 79Late stage assay provider assay for AddAB inhibitors: Radioactivity-based biochemical dose response assay to identify inhibitors of the nuclease activity of purified AddAB [AID602421, Type: confirmatory]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
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10
[SID92093432]
IC50 103.66A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi (2) using purified and synthesized compounds [AID2840, Type: confirmatory]
View
11
[SID126920298]
Late stage assay provider assay for AddAB inhibitors: Radioactivity-based biochemical assay to identify inhibitors of the nuclease activity of purified AddAB (100 micromolar dose) [AID602422, Type: other]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
View
12
[SID126920298]
Late stage assay provider counterscreen for AddAB inhibitors: Radioactivity-based biochemical assay to identify inhibitors of the nuclease activity of purified RecBCD enzyme (at 100 micromolar) [AID623921, Type: other]exonuclease V (RecBCD complex), gamma chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130726]
View
13
[SID126920298]
Late stage assay provider assay for AddAB inhibitors: Radioactivity-based biochemical assay to identify inhibitors of the nuclease activity of purified AddAB (100 micromolar dose) [AID602422, Type: other]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
View
14
[SID126920298]
Late stage assay provider counterscreen for AddAB inhibitors: Radioactivity-based biochemical assay to identify inhibitors of the nuclease activity of purified RecBCD enzyme (at 100 micromolar) [AID623921, Type: other]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
View
15
[SID92093432]
Visually Observed Polymyxin Resistance IC50 Salmonella typhi: Polymyxin resistance assay (2) [AID2811, Type: confirmatory]
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16
[SID92093432]
Visually Observed Polymyxin Resistance IC50 Salmonella typhimurium: Polymyxin resistance assay (2) [AID2816, Type: confirmatory]
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