denatonium benzoate (CID 19518) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(2)
 
 
Inactive(530)
 
 
Inconclusive(22)
 
 
Unspecified(5)
 
 
Top Targets:
p450(10)
 
 
 
7TM GPCR Srx(9)
 
 
NR LBD TR(6)
 
 
 
7TM GPCR Srsx(5)
 
 
NR LBD PPAR(5)
 
 
 
BioAssay Types:
Screening(255)
 
 
Confirmatory(204)
 
 
 
 
 
Literature(68)
 
 
 
 
BioActivity Types:
Potency(168)
 
 
 
 
 
IC50(11)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 456    Data Row: 559   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID11112959]
Potency 0.0079qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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2
[SID11112959]
 Cytochrome panel assay with activity outcomes [AID1851_2, Type: other]cytochrome P450, family 2, subfamily D, polypeptide 6 isoform 2 [Homo sapiens] [gi:68509921]
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3
[SID11112959]
 Cytochrome panel assay with activity outcomes [AID1851_2, Type: other]cytochrome P450, family 2, subfamily D, polypeptide 6 isoform 2 [Homo sapiens] [gi:68509921]
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4
[SID26757851]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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5
[SID26757851]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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6
[SID11112959]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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7
[SID11112959]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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8
[SID56463089]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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9
[SID56463089]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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10
[SID104171335]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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11
[SID11112959]
Potency 1.4125qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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12
[SID11112959]
Potency 1.4125qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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13
[SID56463089]
 HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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14
[SID11112959]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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15
[SID11112959]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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16
[SID11112959]
Potency qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. [AID1467, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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17
[SID11112959]
Potency qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. [AID1467, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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18
[SID56463089]
Potency qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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19
[SID56463089]
Potency qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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20
[SID104171335]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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21
[SID104171335]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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22
[SID56463089]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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23
[SID56463089]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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24
[SID56463089]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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25
[SID104171335]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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26
[SID56463089]
Potency qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624288, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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27
[SID11112959]
 GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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28
[SID11112959]
 GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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29
[SID11112959]
 GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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30
[SID11112959]
 GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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31
[SID11112959]
 GR-EFC Redistribution [AID451, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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32
[SID11112959]
 GR-EFC Redistribution [AID451, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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33
[SID11112959]
 GR-EFC Redistribution [AID451, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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34
[SID11112959]
 GR-EFC Redistribution [AID451, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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35
[SID26757851]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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36
[SID26757851]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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37
[SID26757851]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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38
[SID26757851]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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39
[SID26757851]
Potency qHTS assay for small molecule antagonists of glucocorticoid receptor signaling [AID588533, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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40
[SID26757851]
Potency qHTS assay for small molecule antagonists of glucocorticoid receptor signaling [AID588533, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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41
[SID26757851]
Potency qHTS assay for small molecule antagonists of glucocorticoid receptor signaling [AID588533, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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42
[SID26757851]
Potency qHTS assay for small molecule antagonists of glucocorticoid receptor signaling [AID588533, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
View
43
[SID56463089]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of GSK-3 alpha [AID2650, Type: screening]GSK3A gene product [Homo sapiens] [gi:49574532]
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44
[SID56463089]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of GSK-3 alpha [AID2650, Type: screening]GSK3A gene product [Homo sapiens] [gi:49574532]
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45
[SID11112959]
Potency qHTS Assay for Modulators of Hemoglobin Beta Chain Splicing [AID925, Type: confirmatory]hemoglobin subunit beta [Homo sapiens] [gi:4504349]
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46
[SID56463089]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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47
[SID56463089]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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48
[SID56463089]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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49
[SID56463089]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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50
[SID26757851]
Potency qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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