Tacrine (CID 1935) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(334)
 
 
Inactive(272)
 
 
Inconclusive(104)
 
 
Unspecified(1785)
 
 
Top Targets:
Esterase lipa..(191)
 
 
 
 
p450(31)
 
 
 
 
 
7TM GPCR Srx(18)
 
 
 
7TM GPCR Srsx(12)
 
 
 
 
Pyr redox dim(7)
 
 
 
 
BioAssay Types:
Literature(649)
 
 
 
 
 
Confirmatory(261)
 
 
 
 
 
Screening(17)
 
 
BioActivity Types:
IC50(396)
 
 
 
 
Potency(218)
 
 
 
 
 
Ki(26)
 
 
 
EC50(4)
 
 
 
Kd(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2332    Data Row: 2495   Total Pages: 50   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103172304]
IC50 1e-05Antioxidant activity against AAPH-induced peroxyl radicals assessed as trolox equivalents measured for 80 mins by ORAC-FL method [AID491968, Type: Literature]
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2
[SID103172304]
IC50 2.67e-05Inhibition of BChE by Ellman's method [AID612151, Type: Literature]
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3
[SID103172304]
Ki 0.000151Inhibition constant determined against Acetylcholinesterase (AChE) receptor. [AID30251, Type: Literature]
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4
[SID103172304]
IC50 0.0009In vitro inhibitory activity against Butyrylcholinesterase (BChE) in human serum [AID44289, Type: Literature]
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5
[SID103172304]
IC50 0.00316Inhibition of AChE by Ellman's method [AID612150, Type: Literature]
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6
[SID103172304]
IC50 0.0038Inhibition of equine serum butyrylcholine esterase using butyrylcholine chloride as substrate incubated for 5 mins prior to substrate addition measured every 3 mins by Ellman's assay [AID663237, Type: Literature]
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7
[SID103172304]
IC50 0.004Inhibition of horse serum butyrylcholine esterase in presence of acetylcholine substrate by chemiluminescent assay [AID384079, Type: Literature]Cholinesterase [gi:21362409]
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8
[SID103172304]
IC50 0.0049Inhibition of horse serum BChE preincubated for 5 mins by Ellman's method [AID548340, Type: Literature]Cholinesterase [gi:21362409]
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9
[SID103172304]
IC50 0.00497Inhibition of equine serum BChE by modified Ellman's method [AID480449, Type: Literature]Cholinesterase [gi:21362409]
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10
[SID103172304]
IC50 0.0051Inhibition of BuChE from equine serum [AID412867, Type: Literature]Butyrylcholinesterase [gi:75074633]
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11
[SID103172304]
IC50 0.0051Inhibition of equine BChE by Ellman's assay [AID331669, Type: Literature]Butyrylcholinesterase [gi:75074633]
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12
[SID103172304]
IC50 0.0051Inhibition of BuChE by Ellman's assay [AID315734, Type: Literature]
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13
[SID103172304]
IC50 0.00513Inhibition of BChE from equine serum by Ellman's method [AID459731, Type: Literature]Cholinesterase [gi:21362409]
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14
[SID103172304]
IC50 0.00517Inhibition of (BChE) Butyrylcholinesterase of horse serum [AID44453, Type: other]
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15
[SID103172304]
IC50 0.0052Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 15 mins by Ellman's method [AID658004, Type: Literature]
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16
[SID103172304]
IC50 0.0052Inhibition of Equus caballus BChE preincubated for 10 mins measured after 15 mins by Ellman's method [AID663977, Type: Literature]
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17
[SID103172304]
IC50 0.0052Inhibition of equine serum BuChE by Ellman's method [AID482854, Type: Literature]Cholinesterase [gi:21362409]
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18
[SID103172304]
IC50 0.0052Inhibition of horse serum BChE after 15 mins by Ellman's method [AID567065, Type: Literature]Cholinesterase [gi:21362409]
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19
[SID103172304]
IC50 0.0052Inhibition of horse serum butyrylcholinesterase preincubated with compound for 10 mins using butrylcholine iodide as substrate after 15 mins by spectrophotometric analysis [AID590995, Type: Literature]Cholinesterase [gi:21362409]
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20
[SID103172304]
IC50 0.0052Inhibition of horse serum BuChE by Ellman's method [AID552791, Type: Literature]Cholinesterase [gi:21362409]
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21
[SID103172304]
IC50 0.0052Inhibition of equine serum BuChE using butylthiocholine iodide as substrate preincubated for 10 mins before substrate addition by Ellman's method [AID629635, Type: Literature]Cholinesterase [gi:21362409]
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22
[SID103172304]
IC50 0.006Compound was evaluated for the in vitro inhibition of the Butyrylcholinesterase from horse serum [AID44452, Type: Literature]
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23
[SID103172304]
IC50 0.006In vitro inhibition of Butyrylcholinesterase from human erythrocytes [AID44287, Type: Literature]
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24
[SID103172304]
IC50 0.006Concentration required to inhibit 50% of Butyrylcholinesterase obtained from human serum was determined in vitro [AID44284, Type: Literature]
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25
[SID103172304]
IC50 0.0064Inhibition of equine serum BChE by Ellman's method [AID569582, Type: Literature]Cholinesterase [gi:21362409]
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26
[SID103172304]
IC50 0.00695Inhibition of horse serum BChE by Ellman's method [AID458511, Type: Literature]Cholinesterase [gi:21362409]
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27
[SID103172304]
Ki 0.007Inhibition of equine (Eq) Butyrylcholinesterase [AID44129, Type: Literature]
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28
[SID103172304]
Ki 0.007Inhibition of Equine Butyrylcholinesterase [AID44133, Type: Literature]
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29
[SID103172304]
Ki 0.007Dissociation constant for inhibition of equine Butyrylcholinesterase (BuChE) [AID238704, Type: Literature]
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30
[SID103172304]
Ki 0.007Inhibition of human recombinant BuChE [AID404429, Type: Literature]Cholinesterase [gi:116353]
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31
[SID103172304]
Ki 0.007Inhibition of human recombinant BChE [AID349046, Type: Literature]Cholinesterase [gi:116353]
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32
[SID103172304]
Ki 0.007Inhibition of human BuChE [AID265949, Type: Literature]Cholinesterase [gi:116353]
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33
[SID103172304]
IC50 0.0076Inhibitory activity against Acetylcholinesterase [AID31496, Type: Literature]
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34
[SID103172304]
IC50 0.0082Inhibition of activity against Torpedo Ray acetylcholinesterase. [AID30663, Type: Literature]Acetylcholinesterase [gi:543754]
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35
[SID103172304]
IC50 0.009Inhibition of rat plasma butyrylcholine esterase in presence of butyrylcholine substrate by chemiluminescent assay [AID384081, Type: Literature]Butyrylcholinesterase [gi:81917534]
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36
[SID103172304]
IC50 0.00933Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assay [AID30867, Type: other]Acetylcholinesterase [gi:14916521]
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37
[SID103172304]
Ki 0.01Tested for in vitro inhibition of acetylcholinesterase [AID31006, Type: other]Acetylcholinesterase [gi:14916521]
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38
[SID103172304]
IC50 0.01Inhibition of BuChE in horse serum using butyrylthiocholine as substrate by Ellman method [AID639367, Type: Literature]
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39
[SID103172304]
IC50 0.01Inhibition of BuChE from horse serum [AID257806, Type: Literature]Butyrylcholinesterase [gi:75074633]
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40
[SID103172304]
IC50 0.01Inhibition of horse serum BChE by Ellman's method [AID656040, Type: Literature]
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41
[SID103172304]
IC50 0.01Inhibitory concentration against Butyrylcholinesterase activity [AID241118, Type: Literature]
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42
[SID103172304]
IC50 0.01Inhibition of equine serum BChE by Ellman's method [AID462834, Type: Literature]Cholinesterase [gi:21362409]
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43
[SID103172304]
IC50 0.01Inhibition of BuChE in horse serum by Ellman method [AID469396, Type: Literature]Cholinesterase [gi:21362409]
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44
[SID103172304]
IC50 0.01Inhibition of equine serum BuchE [AID407147, Type: Literature]Cholinesterase [gi:21362409]
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45
[SID103172304]
IC50 0.01Inhibition of horse serum BChE by Ellman's reaction [AID491975, Type: Literature]Cholinesterase [gi:21362409]
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46
[SID103172304]
IC50 0.01Inhibition of equine serum BuChE by Ellman's method [AID548344, Type: Literature]Cholinesterase [gi:21362409]
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47
[SID103172304]
IC50 0.0102Inhibition of human butyrylcholinesterase [AID303072, Type: Literature]
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48
[SID103172304]
IC50 0.011Inhibition of equine serum BChE by Ellman's method [AID594255, Type: Literature]Cholinesterase [gi:21362409]
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49
[SID103172304]
IC50 0.012Inhibition of BChE [AID594821, Type: Literature]
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50
[SID103172304]
IC50 0.013Inhibition of equine serum butyrylcholinesterase using butylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition measured every 1 min by Ellman's assay [AID666575, Type: Literature]
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