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AC1LYX8J (CID 1909760) - Compound BioActivity Data
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BioActivity Outcomes:
Active(57)
 
 
Inactive(404)
 
 
Inconclusive(31)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(20)
 
 
7TM GPCR Srsx(18)
 
 
 
Tryp SPc(9)
 
 
 
G-alpha(8)
 
 
 
ANK(5)
 
 
BioAssay Types:
Screening(300)
 
 
 
 
Confirmatory(181)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(137)
 
 
 
 
 
IC50(33)
 
 
 
 
EC50(4)
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 446    Data Row: 493   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26725982]
Potency 0.919qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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2
[SID26725982]
Potency 1.5849qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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3
[SID26725982]
Potency 2.6679qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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4
[SID26725982]
Potency 3.1623qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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5
[SID26725982]
Potency 3.1623qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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6
[SID26725982]
IC50 3.45Dose Response validation of uHTS RPN11 inhibitor hits using a MMP-2 Fluorescence assay [AID602361, Type: confirmatory]72 kDa type IV collagenase isoform a preproprotein [Homo sapiens] [gi:11342666]
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7
[SID26725982]
IC50 4Dose response confirmation of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID602386, Type: confirmatory]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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8
[SID26725982]
IC50 4.84159Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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9
[SID26725982]
IC50 6.76Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay [AID602368, Type: confirmatory]PSMD14 protein [Homo sapiens] [gi:16306916]
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10
[SID26725982]
Potency 7.9433qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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11
[SID26725982]
Potency 7.9433qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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12
[SID26725982]
Potency 10HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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13
[SID26725982]
Potency 10qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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14
[SID26725982]
Potency 11.2202qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase [AID602233, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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15
[SID26725982]
Potency 11.9173qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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16
[SID26725982]
Potency 12.5893qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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17
[SID26725982]
Potency 15.8489qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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18
[SID26725982]
Potency 16.9441qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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19
[SID26725982]
Potency 22.3872qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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20
[SID26725982]
Potency 25.1189qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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21
[SID26725982]
Potency 31.6228qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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22
[SID26725982]
Potency 35.4813qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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23
[SID26725982]
IC50 55.68Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]rac GTPase-activating protein 1 [Homo sapiens] [gi:21361397]
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24
[SID26725982]
Potency 60.1198qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds [AID720498, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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25
[SID26725982]
IC50 66.52Inhibitors of Mycobacterial Glucosamine-1-phosphate acetyl transferase (GlmU) [AID1376, Type: confirmatory]Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU [Mycobacterium tuberculosis H37Rv] [gi:15608158]
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26
[SID26725982]
IC50 84.7Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay [AID602369, Type: confirmatory]TPA: prothrombin [Bos taurus] [gi:296479639]
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27
[SID26725982]
uHTS for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID782, Type: screening]eukaryotic translation initiation factor 4 gamma 1 isoform 4 [Homo sapiens] [gi:302699239]
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28
[SID26725982]
uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) [AID493160, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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29
[SID26725982]
TRFRET-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): antagonists of MC4R [AID540295, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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30
[SID26725982]
Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of binding of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) to methylated oligonucleotide [AID687016, Type: screening]E3 ubiquitin-protein ligase UHRF1 isoform 1 [Homo sapiens] [gi:115430235]
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31
[SID26725982]
Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based biochemical high throughput screening assay to identify inhibitors of binding of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) to methylated oligonucleotide [AID720530, Type: screening]E3 ubiquitin-protein ligase UHRF1 isoform 1 [Homo sapiens] [gi:115430235]
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32
[SID26725982]
uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]tyrosine-protein phosphatase non-receptor type 5 isoform a [Homo sapiens] [gi:90652859]
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33
[SID26725982]
Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID743445, Type: screening]histone-lysine N-methyltransferase NSD2 isoform 1 [Homo sapiens] [gi:109633019]
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34
[SID26725982]
uHTS for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID782, Type: screening]eukaryotic translation initiation factor 4E [Mus musculus] [gi:83627717]
View
35
[SID26725982]
IC50 uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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36
[SID26725982]
IC50 uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
View
37
[SID26725982]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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38
[SID26725982]
VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID686996, Type: screening]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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39
[SID26725982]
uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assay [AID588493, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
View
40
[SID26725982]
Single concentration confirmation of uHTS inhibitor hits from RPN11 in a Fluorescence Polarization assay [AID602318, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
View
41
[SID26725982]
uHTS Colorimetric assay for identification of inhibitors of Scp-1 [AID493091, Type: screening]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
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42
[SID26725982]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
View
43
[SID26725982]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
View
44
[SID26725982]
uHTS for 14-3-3/Bad interaction inhibitors [AID781, Type: screening]14-3-3 protein zeta/delta [Bos taurus] [gi:27807367]
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45
[SID26725982]
MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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46
[SID26725982]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide [AID686964, Type: screening]Methyl-CpG binding domain protein 2 [Homo sapiens] [gi:21595776]
View
47
[SID26725982]
TRFRET-based biochemical high throughput confirmation assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide [AID720531, Type: screening]Methyl-CpG binding domain protein 2 [Homo sapiens] [gi:21595776]
View
48
[SID26725982]
uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assay [AID651999, Type: screening]COP9 signalosome complex subunit 5 [Homo sapiens] [gi:38027923]
View
49
[SID26725982]
uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
View
50
[SID26725982]
Single concentration confirmation of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID602385, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
View