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8-(4-sulfophenyl)theophylline (CID 1908) - Compound BioActivity Data
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BioActivity Outcomes:
Active(34)
 
 
Inactive(229)
 
 
Inconclusive(35)
 
 
Unspecified(8)
 
 
Top Targets:
7TM GPCR Srsx(12)
 
 
 
 
p450(9)
 
 
 
7TM GPCR Srx(7)
 
 
 
 
PLN02808(6)
 
 
 
ANK(6)
 
 
BioAssay Types:
Confirmatory(235)
 
 
 
 
 
Literature(42)
 
 
 
 
 
Screening(13)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(210)
 
 
 
 
 
Ki(20)
 
 
 
IC50(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 257    Data Row: 306   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167886]
IC50 0.0219Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosine [AID31836, Type: Literature]
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2
[SID103167886]
IC50 0.022Binding affinity against adenosine A1 receptor in rat brain membrane preparations using N6-[3H]cyclohexyladenosine as a radioligand [AID31390, Type: Literature]
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3
[SID103167886]
IC50 0.448Binding affinity against rat brain adenosine A1 receptor using N6-[3H]- cyclohexyladenosine [AID31393, Type: Literature]Adenosine receptor A1 [gi:2827766]
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4
[SID103167886]
Ki 1Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranes [AID32491, Type: Literature]
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5
[SID103167886]
Ki 1Binding affinity for adenosine A1 receptor from rat brain membranes using [3H]PIA as radioligand [AID31887, Type: Literature]
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6
[SID11110670]
Potency 1qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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7
[SID11110670]
Potency 1qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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8
[SID103167886]
Ki 1.33Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand [AID33176, Type: Literature]
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9
[SID103167886]
Ki 1.33Binding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranes [AID33180, Type: Literature]Adenosine receptor A2b [gi:112938]
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10
[SID103167886]
Ki 1.33Displacement of [125I]ABOPX from human recombinant adenosine A2B receptor expressed in CHO cells [AID267465, Type: Literature]Adenosine receptor A2b [gi:112938]
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11
[SID103167886]
Ki 1.5Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat fat cell membrane [AID32487, Type: Literature]
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12
[SID103167886]
Ki 2.6Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand [AID32177, Type: Literature]
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13
[SID103167886]
Ki 4.5Antagonism of binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptors on rat cortical membranes [AID31856, Type: Literature]
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14
[SID103167886]
Ki 5Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via Adenosine A2 receptor in rat PC12 membranes [AID33734, Type: Literature]
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15
[SID103167886]
Ki 5.5Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes. [AID30797, Type: Literature]
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16
[SID103167886]
Ki 5.8Binding affinity for adenosine A2A receptor from rat brain membranes using [3H]CGS-21680 [AID32862, Type: Literature]
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17
[SID103167886]
Ki 5.89Displacement of [125I]AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells [AID267468, Type: Literature]Adenosine receptor A3 [gi:1351831]
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18
[SID103167886]
Ki 6.3Antagonism of cyclic [3H]AMP accumulation in guinea pig cerebral cortical slices (elicited by 15 uM 2-chloroadenosine at adenosine A2 receptor) [AID30621, Type: Literature]Adenosine receptor A2a [gi:1168253]
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19
[SID103167886]
Ki 11Binding affinity for human adenosine A3 receptor using [3H]-PBS-11 in CHO cell membranes [AID33502, Type: Literature]
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20
[SID103167886]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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