8-(4-sulfophenyl)theophylline (CID 1908) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(32)
 
 
Inactive(202)
 
 
Inconclusive(35)
 
 
Unspecified(8)
 
 
Top Targets:
p450(10)
 
 
 
 
7TM GPCR Srsx(9)
 
 
 
 
PLN02808(6)
 
 
 
Pyr redox dim(5)
 
 
HELICc(5)
 
 
BioAssay Types:
Confirmatory(210)
 
 
 
 
 
Literature(41)
 
 
 
 
 
Screening(10)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(186)
 
 
 
 
 
Ki(20)
 
 
 
IC50(9)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 243    Data Row: 277   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167886]
IC50 0.0219Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosine [AID31836, Type: Literature]
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2
[SID103167886]
IC50 0.022Binding affinity against adenosine A1 receptor in rat brain membrane preparations using N6-[3H]cyclohexyladenosine as a radioligand [AID31390, Type: Literature]
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3
[SID103167886]
IC50 0.448Binding affinity against rat brain adenosine A1 receptor using N6-[3H]- cyclohexyladenosine [AID31393, Type: Literature]Adenosine receptor A [gi:2827766]
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4
[SID103167886]
Ki 1Binding affinity for adenosine A1 receptor from rat brain membranes using [3H]PIA as radioligand [AID31887, Type: Literature]
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5
[SID103167886]
Ki 1Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranes [AID32491, Type: Literature]
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6
[SID11110670]
Potency 1qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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7
[SID103167886]
Ki 1.33Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand [AID33176, Type: Literature]
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8
[SID103167886]
Ki 1.33Displacement of [125I]ABOPX from human recombinant adenosine A2B receptor expressed in CHO cells [AID267465, Type: Literature]Adenosine receptor A2 [gi:112938]
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9
[SID103167886]
Ki 1.33Binding affinity for human HEK293 adenosine A2B receptor using [125I]ABOPX in CHO cell membranes [AID33180, Type: Literature]Adenosine receptor A2 [gi:112938]
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10
[SID103167886]
Ki 1.5Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat fat cell membrane [AID32487, Type: Literature]
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11
[SID103167886]
Ki 2.6Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand [AID32177, Type: Literature]
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12
[SID103167886]
Ki 4.5Antagonism of binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptors on rat cortical membranes [AID31856, Type: Literature]
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13
[SID103167886]
Ki 5Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via Adenosine A2 receptor in rat PC12 membranes [AID33734, Type: Literature]
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14
[SID103167886]
Ki 5.5Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes. [AID30797, Type: Literature]
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15
[SID103167886]
Ki 5.8Binding affinity for adenosine A2A receptor from rat brain membranes using [3H]CGS-21680 [AID32862, Type: Literature]
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16
[SID103167886]
Ki 5.89Displacement of [125I]AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells [AID267468, Type: Literature]Adenosine receptor A [gi:1351831]
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17
[SID103167886]
Ki 5.89Displacement of [125I]AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells [AID267468, Type: Literature]Adenosine receptor A [gi:1351831]
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18
[SID103167886]
Ki 6.3Antagonism of cyclic [3H]AMP accumulation in guinea pig cerebral cortical slices (elicited by 15 uM 2-chloroadenosine at adenosine A2 receptor) [AID30621, Type: Literature]Adenosine receptor A2 [gi:1168253]
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19
[SID103167886]
Ki 11Binding affinity for human adenosine A3 receptor using [3H]-PBS-11 in CHO cell membranes [AID33502, Type: Literature]
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20
[SID103167886]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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21
[SID103167886]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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22
[SID103167886]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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23
[SID103167886]
Ki 14Displacement of [3H]R-PIA from adenosine A2A receptor in rat brain striatal membranes [AID267462, Type: Literature]Adenosine receptor A2 [gi:8928539]
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24
[SID103167886]
Ki 14Binding affinity for adenosine A2A receptor using [3H]-NECA in rat brain striatal membranes [AID32868, Type: Literature]Adenosine receptor A2 [gi:8928539]
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25
[SID103167886]
Ki 14Binding affinity for adenosine A1 receptor using [3H]PIA in rat brain cortical membrane [AID32046, Type: Literature]Adenosine receptor A [gi:2827766]
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26
[SID103167886]
Ki 14Displacement of [3H]R-PIA from adenosine A1 receptor in rat brain cortical membranes [AID267459, Type: Literature]Adenosine receptor A [gi:2827766]
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27
[SID103167886]
IC50 15.8489Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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28
[SID11110670]
Potency 15.8489qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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29
[SID103167886]
IC50 15.8489Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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30
[SID103167886]
IC50 15.8489Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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31
[SID103167886]
 Binding affinity against adenosine A2 receptor using [3H]- NECA as radioligand [AID33746, Type: Literature]
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32
[SID11110670]
 qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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33
[SID11110670]
 qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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34
[SID103167886]
 Ratio of A2 to A1. [AID33752, Type: Literature]
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35
[SID103167886]
 Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 uM [AID205268, Type: Literature]
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36
[SID103167886]
 Inhibition of binding of Batrachotoxinin [3H]BTX-B to high-affinity sites on voltage-dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 100 uM [AID205269, Type: Literature]
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37
[SID103167886]
 Ratio of antagonism at A2 versus A1 receptors (Ki values) [AID229822, Type: Literature]
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38
[SID103167886]
 Solubility in water [AID21511, Type: Literature]
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39
[SID103167886]
 Binding affinity against adenosine A1 receptor in rat brain membrane preparations using N6-[3H]cyclohexyladenosine as radioligand, PCY = log (100000/IC50). [AID32636, Type: Literature]
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40
[SID11110670]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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41
[SID11110670]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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42
[SID90340681]
Potency HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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43
[SID90340681]
Potency HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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44
[SID90340681]
Potency HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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45
[SID90340681]
Potency HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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46
[SID11110670]
Potency 0.0891qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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47
[SID11110670]
Potency 0.0891qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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48
[SID11110670]
Potency 0.0891qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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49
[SID85230877]
Potency 3.3587qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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50
[SID85230877]
Potency 3.3587qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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