Bookmark and Share
Adenine (CID 190) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(15)
 
 
Inactive(785)
 
 
Inconclusive(53)
 
 
Unspecified(74)
 
 
Top Targets:
NR LBD PPAR(16)
 
 
 
NR LBD ER(14)
 
 
 
NR LBD AR(14)
 
 
 
7TM GPCR Srx(14)
 
 
7TM GPCR Srsx(13)
 
 
 
BioAssay Types:
Confirmatory(353)
 
 
 
 
 
Screening(340)
 
 
 
Literature(150)
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(312)
 
 
 
 
 
IC50(20)
 
 
 
 
Ki(3)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 718    Data Row: 927   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103517679]
Ki 0.0292Displacement of [3H]adenine from adenine 1 receptor in rat brain cortical membrane by liquid scintillation counting [AID445467, Type: Literature]
View
2
[SID103517679]
Ki 0.0471Displacement of [3H]adenine from adenine 1 receptor in HEK293 cells by liquid scintillation counting [AID445471, Type: Literature]
View
3
[SID103517679]
IC50 8.29Agonist activity at rat adenine 1 receptor expressed in human 1321N1 cells assessed as inhibition of isoproterenol-induced [3H]cAMP formation by scintillation counting [AID445475, Type: Literature]
View
4
[SID103517679]
IC50 10.89Inhibition of human xanthine oxidase [AID287937, Type: Literature]Xanthine dehydrogenase/oxidase [gi:2506326]
View
5
[SID103517679]
IC50 12Potency against non nucleoside reverse transcriptor was determined in MT-4 cells [AID105205, Type: Literature]
View
6
[SID47193680]
Potency 14.1254qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
View
7
[SID170465950]
Ratio Potency (uM) 33.4889qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
View
8
[SID48415517]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
View
9
[SID46392627]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Complex Of [e160a-E189a] Trichosanthin And Adenine [gi:28374046]
View
10
[SID47193680]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
View
11
[SID103517679]
Inhibition of [3H]adenine uptake at rat adenine 1 receptor expressed in human 1321N1 cells at 1 mM after 1 min by liquid scintillation counting [AID445484, Type: Literature]
View
12
[SID46392320]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of E. Coli MtaADOHCY NUCLEOSIDASE [gi:24158768]
View
13
[SID46393497]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Catalytic Domain Of Muty From Escherichia Coli K20a Mutant Complexed To Adenine [gi:55670672]
View
14
[SID26748402]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
View
15
[SID53812922]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Ricin A-Chain (Recombinant) Complex With Adenine [gi:160877710]
View
16
[SID103517679]
IC50 200Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis. [AID51554, Type: Literature]
View
17
[SID103517679]
IC50 4000Binding affinity to ATP binding site of full length human Hsp90beta after 30 mins by fluorescence polarization assay [AID419781, Type: Literature]Heat shock protein HSP 90-beta [gi:17865718]
View
18
[SID103517679]
IC50 12900Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation by continuous spectrophotometric assay in presence of 150 mM NH4Cl [AID453744, Type: Literature]
View
19
[SID103517679]
IC50 15800Inhibition of Escherichia coli recombinant N-terminal hexahistidine-tagged CTP synthetase expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CTP formation by continuous spectrophotometric assay in presence of 10 mM L-glutamine and 0.15 mM GTP [AID453747, Type: Literature]
View
20
[SID103517679]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
View
21
[SID103517679]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
View
22
[SID103517679]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
View
23
[SID103517679]
Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
View
24
[SID103517679]
Inhibition of IKK-beta expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by TR-FRET assay [AID613143, Type: Literature]
View
25
[SID103517679]
Inhibition of PI3Kgamma expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by fluorescence polarization assay [AID613144, Type: Literature]
View
26
[SID103517679]
Inhibition of JNK1 expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by TR-FRET assay [AID613145, Type: Literature]
View
27
[SID103517679]
Inhibition of AKT1 expressed in Escherichia coli or baculovirus-infected insect cells using gamma-[33P]ATP at 400 uM by scintillation proximity assay [AID613147, Type: Literature]
View
28
[SID103517679]
Inhibition of AKT2 expressed in Escherichia coli or baculovirus-infected insect cells using gamma-[33P]ATP at 400 uM by scintillation proximity assay [AID613148, Type: Literature]
View
29
[SID103517679]
Inhibition of ASK1 expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by IMAP assay [AID613149, Type: Literature]
View
30
[SID103517679]
Inhibition of AurA expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by IMAP assay [AID613150, Type: Literature]
View
31
[SID103517679]
Inhibition of AurB expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by IMAP assay [AID613151, Type: Literature]
View
32
[SID103517679]
Inhibition of B-Raf expressed in Escherichia coli or baculovirus-infected insect cells using ATP as substrate at 400 uM by fluorescence polarization assay [AID613152, Type: Literature]
View
33
[SID103517679]
Inhibition of EGFR expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by TR-FRET assay [AID613153, Type: Literature]
View
34
[SID103517679]
Inhibition of FES expressed in Escherichia coli or baculovirus-infected insect cells using ATP as substrate at 400 uM by fluorescence polarization assay [AID613154, Type: Literature]
View
35
[SID103517679]
Inhibition of ErbB2 expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by TR-FRET assay [AID613155, Type: Literature]
View
36
[SID103517679]
Inhibition of ErbB4 expressed in Escherichia coli or baculovirus-infected insect cells at 400 to 667 uM by TR-FRET assay [AID613156, Type: Literature]
View
37
[SID103517679]
Inhibition of FAK expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by TR-FRET assay [AID613157, Type: Literature]
View
38
[SID103517679]
Inhibition of GSK3-beta expressed in Escherichia coli or baculovirus-infected insect cells using ATP as substrate at 667 uM by fluorescence polarization assay [AID613158, Type: Literature]
View
39
[SID103517679]
Inhibition of IGF1R expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by TR-FRET assay [AID613159, Type: Literature]
View
40
[SID103517679]
Inhibition of ITK expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by TR-FRET assay [AID613160, Type: Literature]
View
41
[SID103517679]
Inhibition of JAK3 expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by TR-FRET assay [AID613161, Type: Literature]
View
42
[SID103517679]
Inhibition of MK2 expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by IMAP assay [AID613162, Type: Literature]
View
43
[SID103517679]
Inhibition of p38alpha expressed in Escherichia coli or baculovirus-infected insect cells at 667 uM by TR-FRET assay [AID613163, Type: Literature]
View
44
[SID103517679]
Inhibition of PAK2 expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by IMAP assay [AID613165, Type: Literature]
View
45
[SID103517679]
Inhibition of PDK1 expressed in Escherichia coli or baculovirus-infected insect cells using gamma-[33P]ATP at 400 uM by scintillation proximity assay [AID613166, Type: Literature]
View
46
[SID103517679]
Inhibition of PI3Kalpha expressed in Escherichia coli or baculovirus-infected insect cells using gamma-[33P]ATP at 400 uM by scintillation proximity assay [AID613167, Type: Literature]
View
47
[SID103517679]
Inhibition of PI3Kdelta expressed in Escherichia coli or baculovirus-infected insect cells using gamma-[33P]ATP at 400 uM by scintillation proximity assay [AID613168, Type: Literature]
View
48
[SID103517679]
Inhibition of PIM1 expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by IMAP assay [AID613169, Type: Literature]
View
49
[SID103517679]
Inhibition of RIP2 expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by fluorescence polarization assay [AID613170, Type: Literature]
View
50
[SID103517679]
Inhibition of ROCK1 expressed in Escherichia coli or baculovirus-infected insect cells at 400 uM by IMAP assay [AID613171, Type: Literature]
View