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Acetylcholine (CID 187) - Compound BioActivity Data
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BioActivity Outcomes:
Active(99)
 
 
Inactive(72)
 
 
Inconclusive(10)
 
 
Unspecified(120)
 
 
Top Targets:
Neur chan LBD(72)
 
 
 
 
7TM GPCR Srx(13)
 
 
 
S100PBPR(4)
 
 
 
PLDc mTdp1 2(4)
 
 
NR LBD TR(4)
 
 
BioAssay Types:
Literature(218)
 
 
 
 
 
Confirmatory(69)
 
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(64)
 
 
 
EC50(48)
 
 
 
Ki(43)
 
 
 
 
IC50(20)
 
 
 
 
Kd(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 242    Data Row: 301   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234160]
EC50 0.0011Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay [AID511592, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113118]
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2
[SID104234160]
EC50 0.0011Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining [AID672151, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113118]
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3
[SID104234160]
EC50 0.0012Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay [AID511603, Type: Literature]Muscarinic acetylcholine receptor M5 [gi:543761]
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4
[SID104234160]
EC50 0.0012Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining [AID672153, Type: Literature]Muscarinic acetylcholine receptor M5 [gi:543761]
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5
[SID104234160]
EC50 0.0032Agonist activity at human muscarinic M3 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay [AID511597, Type: Literature]Muscarinic acetylcholine receptor M3 [gi:113125]
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6
[SID104234160]
EC50 0.0032Agonist activity at human muscarinic M3 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining [AID672157, Type: Literature]Muscarinic acetylcholine receptor M3 [gi:113125]
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7
[SID104234160]
Ki 0.0076Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenates [AID239589, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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8
[SID104234160]
Ki 0.0076Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenates [AID239589, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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9
[SID104234160]
EC50 0.01Agonist activity at human muscarinic M4 receptor expressed in BHK-21 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay [AID511600, Type: Literature]Muscarinic acetylcholine receptor M4 [gi:23503039]
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10
[SID104234160]
EC50 0.01Agonist activity at muscarinic human M4 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining [AID672155, Type: Literature]Muscarinic acetylcholine receptor M4 [gi:23503039]
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11
[SID104234160]
Ki 0.011Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID145983, Type: Literature]Neuronal acetylcholine receptor subunit alpha-2 [gi:2851491]
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12
[SID104234160]
Ki 0.011Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID145983, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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13
[SID104234160]
IC50 0.012In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor. [AID141531, Type: Literature]
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14
[SID104234160]
IC50 0.012The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Value ranges from 7-20 [AID141812, Type: Literature]
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15
[SID104234160]
IC50 0.012Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioligand [AID141545, Type: Literature]
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16
[SID104234160]
Ki 0.03311Displacement of [3H]epibatidine from rat recombinant alpha4beta2 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724038, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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17
[SID104234160]
Ki 0.03311Displacement of [3H]epibatidine from rat recombinant alpha4beta2 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724038, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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18
[SID104234160]
Ki 0.0377Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrs [AID536863, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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19
[SID104234160]
Ki 0.0377Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrs [AID536863, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
20
[SID104234160]
Ki 0.039Displacement of [3H]cystisine from nicotinic alpha-4-beta-2 receptor in rat brain [AID320061, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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