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MLS001202719 (CID 18593578) - Compound BioActivity Data
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BioActivity Outcomes:
Active(138)
 
 
Inactive(467)
 
 
Inconclusive(25)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
 
7TM GPCR Srsx(21)
 
 
 
UBCc(6)
 
 
 
NB-ARC(6)
 
 
 
STKc MAP4K3 l..(6)
 
 
 
BioAssay Types:
Screening(411)
 
 
 
Confirmatory(209)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(126)
 
 
 
 
 
IC50(46)
 
 
 
EC50(17)
 
 
 
AC50(13)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 584    Data Row: 631   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49640984]
AbsAC35_uM 0.346Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity [AID652041, Type: confirmatory]
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2
[SID49640984]
AbsAC35_uM 0.401Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity [AID652047, Type: confirmatory]
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3
[SID49640984]
Potency 1.0323qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID49640984]
AC50_uM 1.043Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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5
[SID49640984]
AC50_uM 1.093ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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6
[SID49640984]
Potency 1.2995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID49640984]
EC50 1.64A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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8
[SID49640984]
Potency 1.6511Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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9
[SID49640984]
EC50 2.2A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhimurium identified in the primary screen [AID2253, Type: confirmatory]
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10
[SID49640984]
Potency 2.5119qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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11
[SID49640984]
EC50_MICROM 3.05Dose Response Confirmation via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Wildtype [AID1897, Type: confirmatory]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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12
[SID49640984]
IC50_Mean 3.08Dose response counterscreen of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489020, Type: confirmatory]
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13
[SID49640984]
AC50_uM 3.917Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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14
[SID49640984]
AC50_uM 4.02HIV-1 Cell Fusion assay for clade B Env AD8 Measured in Cell-Based System Using Plate Reader - 7013-04_Inhibitor_Dose_CherryPick_Activity [AID652062, Type: confirmatory]
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15
[SID49640984]
IC50_Mean 4.4Dose response confirmation of uHTS of chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489004, Type: confirmatory]
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16
[SID49640984]
Potency 4.4668VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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17
[SID49640984]
Potency 5.8048A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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18
[SID49640984]
AbsAC1000_uM 6.391In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity [AID540271, Type: confirmatory]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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19
[SID49640984]
EC50 6.686Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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20
[SID49640984]
AC50_uM 6.91CEM21 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7013-03_Inhibitor_Dose_CherryPick_Activity [AID652042, Type: confirmatory]
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21
[SID49640984]
EC50 7.282Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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22
[SID49640984]
AC50_uM 7.458Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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23
[SID49640984]
IC50_Mean 8.06Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent TIM10 yeast counterscreen [AID504542, Type: confirmatory]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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24
[SID49640984]
EC50_uM 8.91Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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25
[SID49640984]
IC50 10.17A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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26
[SID49640984]
IC50_Mean 10.9Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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27
[SID49640984]
IC50_Mean 10.9Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-9 isoform alpha precursor [Homo sapiens] [gi:14790124]
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28
[SID49640984]
IC50_Mean 10.9Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID493003, Type: confirmatory]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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29
[SID49640984]
IC50_Mean 12Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. [AID504544, Type: confirmatory]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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30
[SID49640984]
AC50_uM 12.3Control Cell Fusion Counterscreen Assay Measured in Cell-Based System Using Plate Reader - 7013-02_Inhibitor_Dose_CherryPick_Activity [AID652040, Type: confirmatory]
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31
[SID49640984]
EC50_uM 12.48Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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32
[SID49640984]
EC50 12.714Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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33
[SID49640984]
EC50_Mean 12.8Dose response counterscreen for uHTS small molecule activators of the adaptive arm of the Unfolded Protein Response via a luminescent-based reporter assay [AID489027, Type: confirmatory]
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34
[SID49640984]
AC50_uM 13.39Luminescence Whole-Organism Dose Retest to Confirm Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID463204, Type: confirmatory]
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35
[SID49640984]
Potency 14.1254qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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36
[SID49640984]
Potency 14.1254qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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37
[SID49640984]
IC50_Mean 14.3Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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38
[SID49640984]
Potency 14.581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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39
[SID49640984]
IC50 15.067Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm [AID493182, Type: confirmatory]ubiquitin-conjugating enzyme E2 N [Homo sapiens] [gi:4507793]
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40
[SID49640984]
IC50 15.636Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID493155, Type: confirmatory]ubiquitin-conjugating enzyme E2 N [Homo sapiens] [gi:4507793]
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41
[SID49640984]
EC50_Mean 18.1Dose response confirmation of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID489032, Type: confirmatory]
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42
[SID49640984]
IC50 18.4Dose Response confirmation of UBC13 Polyubiquitin Inhibitors using a Bfl-1 counterscreen [AID504689, Type: confirmatory]bcl-2-related protein A1 [Mus musculus] [gi:11024684]
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43
[SID49640984]
IC50 20.01A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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44
[SID49640984]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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45
[SID49640984]
IC50 21.42A Counter Screen to identiry small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID2401, Type: confirmatory]
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46
[SID49640984]
IC50 25.401A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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47
[SID49640984]
AbsAC35_uM 26.73Mammalian cell toxicity counterscreen to identify toxic HSP40 inhibitor compounds in NIH3T3 cells Measured in Cell-Based System Using Plate Reader - 2120-03_Inhibitor_Dose_CherryPick_Activity_Set2 [AID624265, Type: confirmatory]
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48
[SID49640984]
IC50 28.55A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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49
[SID49640984]
IC50 37.04A screen for inhibitors of the PhoP regulon in Salmonella Typhimurium using a modified counterscreen. [AID1981, Type: confirmatory]
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50
[SID49640984]
Potency 44.6684qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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