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AGN-PC-01YMZO (CID 18593578) - Compound BioActivity Data
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BioActivity Outcomes:
Active(138)
 
 
Inactive(475)
 
 
Inconclusive(25)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
 
7TM GPCR Srsx(21)
 
 
 
NB-ARC(6)
 
 
 
STKc MAP4K3 l..(6)
 
 
 
UBCc(6)
 
 
 
BioAssay Types:
Screening(413)
 
 
 
Confirmatory(209)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(126)
 
 
 
 
 
IC50(46)
 
 
 
EC50(17)
 
 
 
AC50(13)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 586    Data Row: 639   Total Pages: 32   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49640984]
AbsAC35_uM 0.346Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity [AID652041, Type: confirmatory]
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2
[SID49640984]
AbsAC35_uM 0.401Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity [AID652047, Type: confirmatory]
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3
[SID49640984]
Potency 1.0323qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID49640984]
AC50_uM 1.043Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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5
[SID49640984]
AC50_uM 1.093ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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6
[SID49640984]
Potency 1.2995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID49640984]
EC50 1.64A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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8
[SID49640984]
Potency 1.6511Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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9
[SID49640984]
EC50 2.2A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhimurium identified in the primary screen [AID2253, Type: confirmatory]
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10
[SID49640984]
Potency 2.5119qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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11
[SID49640984]
EC50_MICROM 3.05Dose Response Confirmation via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Wildtype [AID1897, Type: confirmatory]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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12
[SID49640984]
IC50_Mean 3.08Dose response counterscreen of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489020, Type: confirmatory]
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13
[SID49640984]
AC50_uM 3.917Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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14
[SID49640984]
AC50_uM 4.02HIV-1 Cell Fusion assay for clade B Env AD8 Measured in Cell-Based System Using Plate Reader - 7013-04_Inhibitor_Dose_CherryPick_Activity [AID652062, Type: confirmatory]
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15
[SID49640984]
IC50_Mean 4.4Dose response confirmation of uHTS of chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489004, Type: confirmatory]
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16
[SID49640984]
Potency 4.4668VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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17
[SID49640984]
Potency 5.8048A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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18
[SID49640984]
AbsAC1000_uM 6.391In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity [AID540271, Type: confirmatory]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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19
[SID49640984]
EC50 6.686Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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20
[SID49640984]
AC50_uM 6.91CEM21 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7013-03_Inhibitor_Dose_CherryPick_Activity [AID652042, Type: confirmatory]
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