scutellarin (CID 185617) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Inactive(3)
 
 
Unspecified(17)
 
 
Top Targets:
NR LBD ER(2)
 
 
Ald Xan dh C2(1)
 
 
BioAssay Types:
Literature(22)
 
 
 
 
BioActivity Types:
IC50(4)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 23    Data Row: 23   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103582387]
IC50 47.3Inhibition of Influenza A Jinan/15/90 H3N2 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay [AID366284, Type: Literature]
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2
[SID103582387]
 Binding affinity to hen egg white lysozyme assessed as reduction in fluorescence intensity at 1 to 7 x 10'-6 M at 298 K [AID629621, Type: Literature]
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3
[SID103582387]
 Binding affinity to hen egg white lysozyme assessed as reduction in fluorescence intensity at 1 to 7 x 10'-6 M at 310 K [AID629620, Type: Literature]
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4
[SID103582387]
IC50 50.6Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay [AID366285, Type: Literature]
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5
[SID103582387]
IC50 59.9Inhibition of Influenza A Jiangsu/10/2003 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay [AID366286, Type: Literature]
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6
[SID103582387]
IC50 63.4Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells [AID355721, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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7
[SID103582387]
IC50 63.4Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells [AID355721, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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8
[SID103582387]
IC50 63.4Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells [AID355721, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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9
[SID103582387]
 Inhibition of cow milk xanthine oxidase at 50 ug/mL [AID338974, Type: other]Xanthine dehydrogenase/oxidase [gi:109940048]
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10
[SID103582387]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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11
[SID103582387]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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12
[SID103582387]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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13
[SID103582387]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
View
14
[SID103582387]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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15
[SID103582387]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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16
[SID103582387]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
View
17
[SID103582387]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
View
18
[SID103582387]
 Binding affinity to hen egg white lysozyme assessed as Stem-Volmer dynamic quenching constant at 310 K by Stern-Volmer plot analysis [AID629623, Type: Literature]
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19
[SID103582387]
 Binding affinity to hen egg white lysozyme assessed as Stem-Volmer dynamic quenching constant at 298 K by Stern-Volmer plot analysis [AID629622, Type: Literature]
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20
[SID103582387]
 Binding affinity to hen egg white lysozyme assessed as quenching rate constant at 310 K by Stern-Volmer plot analysis [AID629625, Type: Literature]
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21
[SID103582387]
 Binding affinity to hen egg white lysozyme assessed as effective quenching constant at 298 K by Lineweaver-Burk plot analysis [AID629626, Type: Literature]
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22
[SID103582387]
 Binding affinity to hen egg white lysozyme assessed as effective quenching constant at 310 K by Lineweaver-Burk plot analysis [AID629627, Type: Literature]
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23
[SID103582387]
 Binding affinity to hen egg white lysozyme assessed as quenching rate constant at 298 K by Stern-Volmer plot analysis [AID629624, Type: Literature]
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24
[SID103582387]
 Binding affinity to hen egg white lysozyme at 298 K [AID629628, Type: Literature]
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25
[SID103582387]
 Binding affinity to hen egg white lysozyme at 310 K [AID629629, Type: Literature]
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26
[SID103582387]
 Antibacterial activity against Staphylococcus aureus [AID629630, Type: Literature]
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27
[SID103582387]
 Binding affinity to hen egg white lysozyme in presence of 2 x10'-3 M [AID629631, Type: Literature]
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28
[SID103582387]
 Antibacterial activity against Staphylococcus aureus in presence of 25 mg/L lysozyme [AID629632, Type: Literature]
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29
[SID103582387]
 Inhibition of HCV NS3 helicase ATP hydrolysis activity overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of inorganic phosphate release by AM/MG-based colometric analysis in the presence of M13 ssDNA [AID671764, Type: Literature]
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30
[SID103582387]
 Inhibition of HCV NS3 helicase overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of DNA unwinding activity at 10 uM by FRET assay [AID671762, Type: Literature]
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31
[SID103582387]
 Inhibition of SARS coronavirus nsP13 helicase activity expressed in Escherichia coli Rosetta assessed inhibition of DNA unwinding activity at 10 uM by FRET assay [AID671761, Type: Literature]
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