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scutellarin (CID 185617) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(5)
 
 
Unspecified(29)
 
 
Top Targets:
NR LBD ER(2)
 
 
7TM GPCR Srsx(1)
 
 
Ald Xan dh C2(1)
 
 
BioAssay Types:
Literature(40)
 
 
 
 
BioActivity Types:
IC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 40    Data Row: 40   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103582387]
IC50 26.78Antioxidant activity assessed as inhibition of DPPH-radical production [AID722692, Type: Literature]
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2
[SID103582387]
IC50 47.3Inhibition of Influenza A Jinan/15/90 H3N2 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay [AID366284, Type: Literature]
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3
[SID103582387]
Aqueous solubility of the compound by UV-Vis spectrophotometric analysis [AID722686, Type: Literature]
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4
[SID103582387]
Antiadipogenic activity in mouse 3T3L1 cells assessed as downregulation of LPL mRNA expression at 10 to 100 uM after 8 days by RT-PCR analysis [AID736702, Type: Literature]
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5
[SID103582387]
Binding affinity to hen egg white lysozyme assessed as reduction in fluorescence intensity at 1 to 7 x 10'-6 M at 310 K [AID629620, Type: Literature]
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6
[SID103582387]
Binding affinity to hen egg white lysozyme assessed as reduction in fluorescence intensity at 1 to 7 x 10'-6 M at 298 K [AID629621, Type: Literature]
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7
[SID103582387]
IC50 50.6Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay [AID366285, Type: Literature]
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8
[SID103582387]
IC50 59.9Inhibition of Influenza A Jiangsu/10/2003 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay [AID366286, Type: Literature]
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9
[SID103582387]
IC50 63.4Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells [AID355721, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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10
[SID103582387]
Inhibition of cow milk xanthine oxidase at 50 ug/mL [AID338974, Type: Literature]Xanthine dehydrogenase/oxidase [gi:109940048]
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11
[SID103582387]
Antiadipogenic activity in mouse 3T3L1 cells assessed as upregulation of PPARalpha mRNA expression after 8 days by RT-PCR analysis [AID736700, Type: Literature]
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12
[SID103582387]
Antiadipogenic activity in mouse 3T3L1 cells assessed as downregulation of C/EBPalpha mRNA expression after 8 days by RT-PCR analysis [AID736703, Type: Literature]
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13
[SID103582387]
Antiadipogenic activity in mouse 3T3L1 cells assessed as downregulation of PPARgamma mRNA expression after 8 days by RT-PCR analysis [AID736704, Type: Literature]
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14
[SID103582387]
Antiadipogenic activity in mouse 3T3L1 cells assessed as decrease in intracellular lipid accumulation incubated for 8 days followed by compound wash out measured for 60 mins by Oil Red O staining-based phase contrast microscopic analysis [AID736705, Type: Literature]
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15
[SID103582387]
Cytotoxicity against mouse 3T3L1 cells assessed as cell viability at < 100 uM after 48 hrs by MTT assay [AID736706, Type: Literature]
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16
[SID103582387]
Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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17
[SID103582387]
Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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18
[SID103582387]
Neuroprotective activity in rat PC12 cells assessed as inhibition of H2O2-induced cytotoxicity at 25 uM after 3 hrs by MTT assay relative to control [AID722693, Type: Literature]
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19
[SID103582387]
Anticoagulant activity in New Zealand white rabbit platelet-poor plasma assessed as fibrinogen content at 100 uM [AID722687, Type: Literature]
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20
[SID103582387]
Anticoagulant activity in New Zealand white rabbit platelet-poor plasma assessed as activated partial thromboplastin time at 100 uM [AID722688, Type: Literature]
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21
[SID103582387]
Anticoagulant activity in New Zealand white rabbit platelet-poor plasma assessed as prothrombin time at 100 uM [AID722689, Type: Literature]
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22
[SID103582387]
Anticoagulant activity in New Zealand white rabbit platelet-poor plasma assessed as thrombin time at 100 uM [AID722690, Type: Literature]
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23
[SID103582387]
Neuroprotective activity in rat PC12 cells assessed as inhibition of H2O2-induced cytotoxicity at 50 uM after 3 hrs by MTT assay relative to control [AID722691, Type: Literature]
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24
[SID103582387]
Binding affinity to hen egg white lysozyme assessed as Stem-Volmer dynamic quenching constant at 298 K by Stern-Volmer plot analysis [AID629622, Type: Literature]
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25
[SID103582387]
Binding affinity to hen egg white lysozyme assessed as Stem-Volmer dynamic quenching constant at 310 K by Stern-Volmer plot analysis [AID629623, Type: Literature]
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26
[SID103582387]
Binding affinity to hen egg white lysozyme assessed as quenching rate constant at 298 K by Stern-Volmer plot analysis [AID629624, Type: Literature]
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27
[SID103582387]
Binding affinity to hen egg white lysozyme assessed as quenching rate constant at 310 K by Stern-Volmer plot analysis [AID629625, Type: Literature]
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28
[SID103582387]
Binding affinity to hen egg white lysozyme assessed as effective quenching constant at 298 K by Lineweaver-Burk plot analysis [AID629626, Type: Literature]
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29
[SID103582387]
Binding affinity to hen egg white lysozyme assessed as effective quenching constant at 310 K by Lineweaver-Burk plot analysis [AID629627, Type: Literature]
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30
[SID103582387]
Binding affinity to hen egg white lysozyme at 298 K [AID629628, Type: Literature]
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31
[SID103582387]
Binding affinity to hen egg white lysozyme at 310 K [AID629629, Type: Literature]
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32
[SID103582387]
Antibacterial activity against Staphylococcus aureus [AID629630, Type: Literature]
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33
[SID103582387]
Binding affinity to hen egg white lysozyme in presence of 2 x10'-3 M [AID629631, Type: Literature]
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34
[SID103582387]
Antibacterial activity against Staphylococcus aureus in presence of 25 mg/L lysozyme [AID629632, Type: Literature]
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35
[SID103582387]
Absolute bioavailability in po dosed Beagle dog [AID718928, Type: Literature]
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36
[SID103582387]
Inhibition of SARS coronavirus nsP13 helicase activity expressed in Escherichia coli Rosetta assessed inhibition of DNA unwinding activity at 10 uM by FRET assay [AID671761, Type: Literature]
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37
[SID103582387]
Inhibition of HCV NS3 helicase overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of DNA unwinding activity at 10 uM by FRET assay [AID671762, Type: Literature]
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38
[SID103582387]
Inhibition of HCV NS3 helicase ATP hydrolysis activity overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of inorganic phosphate release by AM/MG-based colometric analysis in the presence of M13 ssDNA [AID671764, Type: Literature]
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39
[SID103582387]
Effect on PPARdelta mRNA expression in mouse 3T3L1 cells at 10 to 100 uM after 8 days by RT-PCR analysis [AID736699, Type: Literature]
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40
[SID103582387]
Downregulation of C/EBPbeta mRNA expression in mouse 3T3L1 cells at 10 to 100 uM after 8 days by RT-PCR analysis [AID736701, Type: Literature]
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