MLS000722242 (CID 18552806) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(17)
 
 
Inactive(544)
 
 
Inconclusive(22)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
alkPPc(10)
 
 
Bcl-2 like(10)
 
 
7TM GPCR Srsx(7)
 
 
NR LBD PPAR(6)
 
 
BioAssay Types:
Screening(387)
 
 
 
 
 
Confirmatory(183)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(132)
 
 
 
 
 
IC50(37)
 
 
 
EC50(9)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 585    Data Row: 585   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17515522]
Potency 3.5481qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
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2
[SID17515522]
Potency 6.7456qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID17515522]
Potency 11.2202qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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4
[SID17515522]
Potency 11.2202qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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5
[SID17515522]
Potency 11.2202qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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6
[SID17515522]
Potency 11.2202qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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7
[SID17515522]
Potency 11.2202qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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8
[SID17515522]
Potency 22.3872qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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9
[SID17515522]
Potency 22.3872qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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10
[SID17515522]
Potency 35.4813qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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11
[SID17515522]
Potency 39.8107qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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12
[SID17515522]
IC50 150A Counter Screen to identiry small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID2401, Type: confirmatory]
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13
[SID17515522]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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14
[SID17515522]
 High Throughput Imaging Assay for Hepatic Lipid Droplet Formation [AID1656, Type: screening]
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15
[SID17515522]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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16
[SID17515522]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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17
[SID17515522]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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18
[SID17515522]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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19
[SID17515522]
 Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase 2 mutant [AID1530, Type: screening]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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20
[SID17515522]
 Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase 2 mutant [AID1530, Type: screening]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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21
[SID17515522]
 uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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22
[SID17515522]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite H. contortus (hcDAF-12) [AID652067, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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23
[SID17515522]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite S. stercoralis (ssDAF-12) [AID652126, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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24
[SID17515522]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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25
[SID17515522]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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26
[SID17515522]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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27
[SID17515522]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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28
[SID17515522]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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29
[SID17515522]
Potency 1.5849qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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30
[SID17515522]
Potency 2.0787Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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31
[SID17515522]
Potency 3.6898qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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32
[SID17515522]
Potency 11.2202qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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33
[SID17515522]
Potency 100qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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34
[SID17515522]
Potency 100qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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35
[SID17515522]
 HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]Ddit3 gene product [Mus musculus] [gi:160707929]
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36
[SID17515522]
 uHTS for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID782, Type: screening]eukaryotic translation initiation factor 4E [Mus musculus] [gi:83627717]
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37
[SID17515522]
 uHTS for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID782, Type: screening]eukaryotic translation initiation factor 4E [Mus musculus] [gi:83627717]
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38
[SID17515522]
 Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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39
[SID17515522]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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40
[SID17515522]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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41
[SID17515522]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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42
[SID17515522]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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43
[SID17515522]
Potency qHTS of IL-2 Activators [AID652025, Type: confirmatory]Il2 gene product [Mus musculus] [gi:7110653]
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44
[SID17515522]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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45
[SID17515522]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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46
[SID17515522]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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47
[SID17515522]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID1672, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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48
[SID17515522]
IC50 Fluorescence for the identification of compounds that decrease p/CIP protein stability [AID1984, Type: confirmatory]nuclear receptor coactivator 3 [Mus musculus] [gi:118026946]
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49
[SID17515522]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Mus musculus] [gi:6755076]
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50
[SID17515522]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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