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AGN-PC-01PFS0 (CID 18083820) - Compound BioActivity Data
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BioActivity Outcomes:
Active(61)
 
 
Inactive(488)
 
 
Inconclusive(31)
 
 
Unspecified(7)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
 
 
7TM GPCR Srsx(17)
 
 
 
ANK(5)
 
 
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(386)
 
 
 
 
Confirmatory(188)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(119)
 
 
 
 
 
IC50(43)
 
 
 
 
 
EC50(23)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 534    Data Row: 587   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49820795]
EC50 0.06Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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2
[SID49820795]
EC50 0.211Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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3
[SID49820795]
EC50 0.909Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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4
[SID49820795]
EC50 2.241Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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5
[SID49820795]
Potency 2.5119qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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6
[SID49820795]
Potency 3.1623VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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7
[SID49820795]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID49820795]
Potency 3.6964Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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9
[SID49820795]
EC50_MICROM 3.998Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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10
[SID49820795]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID49820795]
EC50 5.269Luminescence Cell-Based Dose Response HTS Screen to Identify Cytotoxic Compounds of NIH3T3 cells. [AID2010, Type: confirmatory]
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12
[SID49820795]
IC50 5.42uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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13
[SID49820795]
Potency 7.3753Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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14
[SID49820795]
CC50 9.95Vero 76 Cytoxicity Assay for VEEV Compounds [AID588719, Type: confirmatory]
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15
[SID49820795]
Potency 11.2202qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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16
[SID49820795]
Potency 12.5893qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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17
[SID49820795]
Potency 16.3601Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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18
[SID49820795]
Potency 19.9526qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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19
[SID49820795]
EC50_MICROM 20.49Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically RPL19A based on MLPCN hits [AID2740, Type: confirmatory]RPL19A [Saccharomyces cerevisiae] [gi:536029]
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20
[SID49820795]
IC50 25A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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21
[SID49820795]
Potency 39.8107qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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22
[SID49820795]
Potency 56.2341qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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23
[SID49820795]
Potency 79.4328qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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24
[SID49820795]
Single concentration confirmation of inhibitors of NALP3 in yeast using a Caspase-1-ASC counter screen [AID488784, Type: screening]NLRP3 protein [Homo sapiens] [gi:219518789]
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25
[SID49820795]
Single concentration confirmation of uHTS for the identification of inhibitors of NALP3 in yeast using a luminescent assay - retest [AID488794, Type: screening]NLRP3 protein [Homo sapiens] [gi:219518789]
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26
[SID49820795]
uHTS Luminescent assay for identification of inhibitors of NALP3 in yeast [AID2825, Type: screening]NLRP3 protein [Homo sapiens] [gi:219518789]
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27
[SID49820795]
Single concentration confirmation of uHTS for the identification of inhibitors of NALP3 in yeast using a luminescent assay [AID435006, Type: screening]NLRP3 protein [Homo sapiens] [gi:219518789]
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28
[SID49820795]
Single concentration confirmation of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463218, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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29
[SID49820795]
uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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30
[SID49820795]
Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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31
[SID49820795]
uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463190, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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32
[SID49820795]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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33
[SID49820795]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_5, Type: confirmatory]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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34
[SID49820795]
uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assay [AID493098, Type: screening]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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35
[SID49820795]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_Activity [AID488899, Type: screening]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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36
[SID49820795]
Fluorescence-based biochemical high throughput confirmation assay to identify inhibitors of Protein Phosphatase 1 (PP1) [AID2358, Type: screening]serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3 [Homo sapiens] [gi:56790945]
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37
[SID49820795]
Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1). [AID2235, Type: screening]serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3 [Homo sapiens] [gi:56790945]
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38
[SID49820795]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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39
[SID49820795]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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40
[SID49820795]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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41
[SID49820795]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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42
[SID49820795]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]BRCA1-associated RING domain protein 1 [gi:116241265]
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43
[SID49820795]
uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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44
[SID49820795]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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45
[SID49820795]
Single concentration confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor via a luminescent beta-arrestin assay [AID602409, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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46
[SID49820795]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_7, Type: confirmatory]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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47
[SID49820795]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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48
[SID49820795]
qHTS Assay for Inhibitors of the Six1/Eya2 Interaction [AID651725, Type: screening]six1 [Homo sapiens] [gi:1246761]
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49
[SID49820795]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_1, Type: confirmatory]apelin receptor [Homo sapiens] [gi:4885057]
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50
[SID49820795]
HTS assay for identification of inhibitors of TNF-a-specific NF-kB induction [AID1852, Type: other]tumor necrosis factor [Homo sapiens] [gi:25952111]
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