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(R)-Ketoprophen (CID 180540) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(248)
 
 
Inconclusive(9)
 
 
Unspecified(13)
 
 
Top Targets:
p450(18)
 
 
HSD10-like SD..(8)
 
 
GH27(5)
 
 
P53(4)
 
 
7tm 2(4)
 
 
BioAssay Types:
Confirmatory(173)
 
 
 
Literature(75)
 
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(127)
 
 
 
IC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 136    Data Row: 275   Total Pages: 14   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103460096]
IC50 0.02Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
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2
[SID103460096]
IC50 0.034Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells [AID248424, Type: Literature]C-X-C chemokine receptor type 1 [gi:108936015]
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3
[SID103460096]
IC50 0.034Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells [AID248424, Type: Literature]C-X-C chemokine receptor type 2 [gi:1352454]
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4
[SID11111348]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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5
[SID11111348]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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6
[SID103460096]
Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M [AID251770, Type: Literature]Prostaglandin G/H synthase 1 [gi:129900]
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7
[SID103460096]
Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M [AID251770, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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8
[SID103460096]
Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M [AID251807, Type: Literature]C-X-C chemokine receptor type 1 [gi:108936015]
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9
[SID103460096]
Noncompetitive inhibition of human CXCR1 assessed as inhibition of CXCL8-induced neutrophile chemotaxis at 10 nM [AID606366, Type: Literature]C-X-C chemokine receptor type 1 [gi:108936015]
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10
[SID11111348]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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11
[SID11112667]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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12
[SID103460096]
Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M [AID251807, Type: Literature]C-X-C chemokine receptor type 2 [gi:1352454]
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13
[SID103460096]
Inhibition of CXCL8-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay [AID297157, Type: Literature]
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14
[SID103460096]
Inhibition of CXCL1-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay [AID297158, Type: Literature]
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15
[SID103460096]
Oral bioavailability in human [AID311524, Type: Literature]
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16
[SID103460096]
Cytotoxicity against of human polymorphonuclear leukocytes assessed as cell viability by trypan blue dye exclusion assay [AID426393, Type: Literature]
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17
[SID103460096]
Cytotoxicity against mouse L1.2 cells assessed as cell viability by trypan blue dye exclusion assay [AID426478, Type: Literature]
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18
[SID11112667]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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19
[SID11112667]
Potency 39.8107qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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20
[SID11111348]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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