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(R)-Ketoprophen (CID 180540) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(248)
 
 
Inconclusive(9)
 
 
Unspecified(13)
 
 
Top Targets:
p450(18)
 
 
HSD10-like SD..(8)
 
 
PLN02808(5)
 
 
BRCT(4)
 
 
NR LBD GR(4)
 
 
BioAssay Types:
Confirmatory(173)
 
 
 
Literature(75)
 
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(127)
 
 
 
IC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 136    Data Row: 275   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103460096]
IC50 0.02Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
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2
[SID103460096]
IC50 0.034Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells [AID248424, Type: Literature]C-X-C chemokine receptor type 1 [gi:108936015]
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3
[SID103460096]
IC50 0.034Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells [AID248424, Type: Literature]C-X-C chemokine receptor type 2 [gi:1352454]
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4
[SID11111348]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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5
[SID11111348]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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6
[SID11111348]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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7
[SID11112667]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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8
[SID11112667]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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9
[SID103460096]
Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M [AID251807, Type: Literature]C-X-C chemokine receptor type 1 [gi:108936015]
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10
[SID103460096]
Noncompetitive inhibition of human CXCR1 assessed as inhibition of CXCL8-induced neutrophile chemotaxis at 10 nM [AID606366, Type: Literature]C-X-C chemokine receptor type 1 [gi:108936015]
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11
[SID103460096]
Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M [AID251770, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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12
[SID103460096]
Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M [AID251807, Type: Literature]C-X-C chemokine receptor type 2 [gi:1352454]
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13
[SID103460096]
Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M [AID251770, Type: Literature]Prostaglandin G/H synthase 1 [gi:129900]
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14
[SID103460096]
Inhibition of CXCL8-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay [AID297157, Type: Literature]
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15
[SID103460096]
Inhibition of CXCL1-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay [AID297158, Type: Literature]
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16
[SID103460096]
Oral bioavailability in human [AID311524, Type: Literature]
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17
[SID103460096]
Cytotoxicity against of human polymorphonuclear leukocytes assessed as cell viability by trypan blue dye exclusion assay [AID426393, Type: Literature]
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18
[SID103460096]
Cytotoxicity against mouse L1.2 cells assessed as cell viability by trypan blue dye exclusion assay [AID426478, Type: Literature]
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19
[SID11112667]
Potency 39.8107qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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20
[SID11112667]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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21
[SID11111348]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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22
[SID11112667]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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23
[SID11112667]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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24
[SID11111348]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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25
[SID11111348]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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26
[SID11111348]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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27
[SID11112667]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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28
[SID11111348]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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29
[SID11112667]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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30
[SID11112667]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1 [AID900, Type: confirmatory]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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31
[SID11111348]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1 [AID900, Type: confirmatory]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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32
[SID11111348]
Potency qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response [AID943, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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33
[SID11111348]
Potency qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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34
[SID11112667]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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35
[SID11112667]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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36
[SID11112667]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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37
[SID11112667]
Potency Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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38
[SID11112667]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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39
[SID11112667]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7 [AID889, Type: confirmatory]Caspase-7 [gi:1730092]
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40
[SID11111348]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7 [AID889, Type: confirmatory]Caspase-7 [gi:1730092]
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41
[SID11111348]
Potency qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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42
[SID11112667]
Potency qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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43
[SID11112667]
JNK3 AlphaScreen Assay [AID530, Type: confirmatory]Mitogen-activated protein kinase 10 [gi:2499604]
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44
[SID11111348]
JNK3 AlphaScreen Assay [AID530, Type: confirmatory]Mitogen-activated protein kinase 10 [gi:2499604]
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45
[SID11111348]
Potency qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Green Fluorophore) [AID879, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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46
[SID11112667]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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47
[SID11112667]
Schistosoma Mansoni Peroxiredoxins (Prx2) [AID448, Type: confirmatory]thioredoxin peroxidase [Schistosoma mansoni] [gi:4325211]
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48
[SID11111348]
Schistosoma Mansoni Peroxiredoxins (Prx2) [AID448, Type: confirmatory]thioredoxin peroxidase [Schistosoma mansoni] [gi:4325211]
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49
[SID11111348]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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50
[SID11111348]
Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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