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BioActivity Data for Compound (R)-Ketoprophen (CID 180540)

BioActivity Outcomes:
Active(5)
 
 
Inactive(248)
 
 
Inconclusive(9)
 
 
Unspecified(16)
 
 
Top Targets:
p450(18)
 
 
HSD10-like SD..(8)
 
 
GH27(5)
 
 
NR LBD GR(4)
 
 
HIF-1a CTAD(4)
 
 
 
BioAssay Types:
Confirmatory(173)
 
 
 
Literature(75)
 
 
 
 
Screening(1)
 
 
BioAssay Categories:
In vitro(2)
 
 
In vivo(1)
 
 
Biochemical(3)
 
 
 
 
Toxicity(6)
 
 
 
ADME(5)
 
 
Cell-based(4)
 
 
BioActivity Types:
Potency(127)
 
 
 
IC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 139    Data Row: 278   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103460096]
IC50 0.02Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
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2
[SID103460096]
IC50 0.034Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells [AID248424, Type: Literature]C-X-C chemokine receptor type 2 [gi:1352454]
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3
[SID103460096]
IC50 0.034Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells [AID248424, Type: Literature]C-X-C chemokine receptor type 1 [gi:108936015]
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4
[SID11111348]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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5
[SID11111348]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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6
[SID11112667]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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7
[SID103460096]
Oral bioavailability in human [AID311524, Type: Literature]
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8
[SID11112667]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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9
[SID11111348]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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10
[SID103460096]
Inhibition of CXCL8-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay [AID297157, Type: Literature]
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11
[SID103460096]
Inhibition of CXCL1-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay [AID297158, Type: Literature]
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12
[SID103460096]
Cytotoxicity against mouse L1.2 cells assessed as cell viability by trypan blue dye exclusion assay [AID426478, Type: Literature]
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13
[SID103460096]
Cytotoxicity against of human polymorphonuclear leukocytes assessed as cell viability by trypan blue dye exclusion assay [AID426393, Type: Literature]
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14
[SID103460096]
Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M [AID251770, Type: Literature]Prostaglandin G/H synthase 1 [gi:129900]
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15
[SID103460096]
Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M [AID251770, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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16
[SID103460096]
Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M [AID251807, Type: Literature]C-X-C chemokine receptor type 1 [gi:108936015]
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17
[SID103460096]
Noncompetitive inhibition of human CXCR1 assessed as inhibition of CXCL8-induced neutrophile chemotaxis at 10 nM [AID606366, Type: Literature]C-X-C chemokine receptor type 1 [gi:108936015]
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18
[SID103460096]
Solubility in pH7.4 buffer using solid starting material using the method described in J. Assoc. Lab. Autom. 2011, 16, 276-284. Experimental range 0.10 to 1500 uM [AID1159388, Type: other]
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19
[SID103460096]
Intrinsic clearance measured in human liver microsomes following incubation at 37C. Experimental range <3 to >150 microL/min/mg. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736. [AID1159394, Type: other]
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20
[SID103460096]
Intrinsic clearance measured in rat hepatocytes following incubation at 37C. Experimental range <3 to >150 microL/min/1E6 cells. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736 [AID1159395, Type: other]
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