R-KETOPROFEN (CID 180540) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(4)
 
 
Inactive(241)
 
 
Inconclusive(9)
 
 
Unspecified(11)
 
 
Top Targets:
p450(20)
 
 
 
PLN02808(5)
 
 
HSD10-like SD..(4)
 
 
HIF-1a CTAD(4)
 
 
 
Pyruvate Kina..(4)
 
 
BioAssay Types:
Confirmatory(166)
 
 
 
Literature(72)
 
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(121)
 
 
 
IC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 137    Data Row: 265   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103460096]
IC50 0.02Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
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2
[SID103460096]
IC50 0.02Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
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3
[SID103460096]
IC50 0.02Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
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4
[SID103460096]
IC50 0.034Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells [AID248424, Type: Literature]C-X-C chemokine receptor type 2 [gi:1352454]
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5
[SID11111348]
 qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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6
[SID11111348]
 qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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7
[SID103460096]
 Noncompetitive inhibition of human CXCR1 assessed as inhibition of CXCL8-induced neutrophile chemotaxis at 10 nM [AID606366, Type: Literature]C-X-C chemokine receptor type 1 [gi:108936015]
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8
[SID103460096]
 Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M [AID251807, Type: Literature]C-X-C chemokine receptor type 2 [gi:1352454]
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9
[SID11111348]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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10
[SID11111348]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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11
[SID103460096]
 Inhibition of CXCL8-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay [AID297157, Type: Literature]
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12
[SID103460096]
 Inhibition of CXCL1-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay [AID297158, Type: Literature]
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13
[SID103460096]
 Oral bioavailability in human [AID311524, Type: Literature]
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14
[SID103460096]
 Cytotoxicity against of human polymorphonuclear leukocytes assessed as cell viability by trypan blue dye exclusion assay [AID426393, Type: Literature]
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15
[SID103460096]
 Cytotoxicity against mouse L1.2 cells assessed as cell viability by trypan blue dye exclusion assay [AID426478, Type: Literature]
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16
[SID11112667]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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17
[SID11112667]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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18
[SID11112667]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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19
[SID103460096]
 Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M [AID251770, Type: Literature]Prostaglandin G/H synthase 1 [gi:129900]
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20
[SID11112667]
Potency 39.8107qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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21
[SID11112667]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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22
[SID11112667]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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23
[SID11111348]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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24
[SID11112667]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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25
[SID11111348]
 qHTS Assay for Inhibitors of YjeE [AID605, Type: confirmatory]UPF0079 ATP-binding protein yjeE [gi:84028058]
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26
[SID11112667]
 qHTS Assay for Inhibitors of YjeE [AID605, Type: confirmatory]UPF0079 ATP-binding protein yjeE [gi:84028058]
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27
[SID11112667]
 Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID584, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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28
[SID11112667]
 Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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29
[SID11111348]
 Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID584, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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30
[SID11111348]
 Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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31
[SID11112667]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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32
[SID11111348]
Potency qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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33
[SID11111348]
Potency qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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34
[SID11112667]
Potency qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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35
[SID11112667]
Potency qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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36
[SID11111348]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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37
[SID11111348]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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38
[SID11112667]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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39
[SID11112667]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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40
[SID11112667]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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41
[SID11112667]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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42
[SID11112667]
Potency qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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43
[SID11112667]
Potency qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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44
[SID11112667]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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45
[SID11112667]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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46
[SID11112667]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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47
[SID11111348]
Potency qHTS Validation Assay for Activators of Leishmania Mexicana Pyruvate Kinase [AID959, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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48
[SID11111348]
Potency qHTS Validation Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase [AID945, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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49
[SID11112667]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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50
[SID11112667]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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