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AN-698/40780857 (CID 1796598) - Compound BioActivity Data
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BioActivity Outcomes:
Active(43)
 
 
Inactive(492)
 
 
Inconclusive(13)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
PTPc(8)
 
 
 
CAP ED(5)
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(368)
 
 
 
Confirmatory(171)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(124)
 
 
 
 
 
IC50(41)
 
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 503    Data Row: 549   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85248321]
IC50_Mean 0.596SAR analysis of compounds that inhibit HePTP - Set 2 [AID449736, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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2
[SID85248321]
IC50_Mean 0.819MOA HePTP Fluorescent secondary assay for identification of redox-state modulating compounds [AID2068, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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3
[SID85248321]
IC50_Mean 1.195Fluorescent secondary assay for dose-response confirmation of chemical inhibitors of HePTP [AID1077, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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4
[SID47199189]
IC50 2.503Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay [AID540297, Type: confirmatory]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
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5
[SID85248321]
IC50_Mean 2.79SAR Selectivity Analysis of small molecule inhibitors of PEST using pCAP in a fluorescence assay [AID488884, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 12 isoform 2 [Homo sapiens] [gi:196114967]
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6
[SID85248321]
IC50_Mean 3.55SAR VHR1 Fluorescent Assay for In Vitro dose response studies Set 2 [AID2684, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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7
[SID85248321]
IC50_Mean 3.95SAR LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies - Set 3 [AID449726, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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8
[SID85248321]
IC50_Mean 4.09SAR LYP1 Fluorescent Assay using pCAP substrate for In Vitro dose response studies - Set 3 [AID449727, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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9
[SID47199189]
Potency 5.7988qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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10
[SID47199189]
IC50 6.608Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID651680, Type: confirmatory]arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2 [Homo sapiens] [gi:351542238]
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11
[SID47199189]
Potency 7.5193qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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12
[SID47199189]
IC50 8.11AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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13
[SID47199189]
IC50 8.11AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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14
[SID47199189]
IC50 8.11AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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15
[SID47199189]
IC50 13.55uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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16
[SID47199189]
IC50 13.55uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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17
[SID47199189]
IC50 13.55uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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18
[SID47199189]
Potency 15.104qHTS for Inhibitors of the Phosphatase Activity of Eya2: Carboxyl-terminal binding protein (CtBP) Counterscreen for Cherry-picked Compounds [AID720541, Type: confirmatory]C-terminal-binding protein 1 [gi:6014741]
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19
[SID85248321]
IC50_Mean 17.8In Vitro MKP-3 Dose Response Assay for SAR Study [AID1055, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
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20
[SID47199189]
Potency 19.0148qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds [AID720540, Type: confirmatory]eyes absent homolog 2 isoform a [Homo sapiens] [gi:26667227]
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21
[SID47199189]
Potency 19.9526HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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22
[SID47199189]
Potency 23.7781qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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23
[SID47199189]
Potency 25.1189qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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24
[SID47199189]
Potency 36.8977qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS [AID602179, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
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25
[SID47199189]
Potency 39.8107qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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26
[SID47199189]
Potency 39.8107qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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27
[SID47199189]
Potency 39.8107qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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28
[SID47199189]
Potency 42.2841qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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29
[SID47199189]
Potency 44.6684qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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30
[SID47199189]
Potency 44.6684qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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31
[SID47199189]
Potency 47.7548qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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32
[SID47199189]
Potency 50.1187qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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33
[SID47199189]
Potency 70.7946Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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34
[SID47199189]
Potency 75.6863qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds [AID720498, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
View
35
[SID47199189]
uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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36
[SID47199189]
uHTS Colorimetric assay for identification of inhibitors of Scp-1 [AID493091, Type: screening]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
View
37
[SID47199189]
Single concentration confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay [AID540281, Type: screening]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
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38
[SID47199189]
uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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39
[SID47199189]
VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID686996, Type: screening]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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40
[SID47199189]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) [AID651572, Type: screening]ADP-ribosylation factor GTPase-activating protein 1 [Rattus norvegicus] [gi:21489979]
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41
[SID47199189]
uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]tyrosine-protein phosphatase non-receptor type 5 isoform a [Homo sapiens] [gi:90652859]
View
42
[SID47199189]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID624377, Type: screening]arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2 [Homo sapiens] [gi:351542238]
View
43
[SID47199189]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID624431, Type: screening]arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2 [Homo sapiens] [gi:351542238]
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44
[SID47199189]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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45
[SID47199189]
Potency 14.7157Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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46
[SID47199189]
Potency 31.6228qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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47
[SID47199189]
Potency 31.6228qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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48
[SID47199189]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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49
[SID47199189]
Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-01_Inhibitor_SinglePoint_HTS_Activity [AID602481, Type: screening]bioA [Mycobacterium tuberculosis UT205] [gi:378544807]
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50
[SID47199189]
Identification of agents that induce E-selectin on human endothelial cells Measured in Cell-Based System Using Imaging - 2152-01_Activator_SinglePoint_HTS_Activity [AID686992, Type: screening]E-selectin precursor [Homo sapiens] [gi:187960042]
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