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AN-698/40780857 (CID 1796598) - Compound BioActivity Data
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BioActivity Outcomes:
Active(43)
 
 
Inactive(499)
 
 
Inconclusive(13)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
PTPc(8)
 
 
 
CAP ED(5)
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(369)
 
 
 
Confirmatory(171)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(124)
 
 
 
 
 
IC50(41)
 
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 504    Data Row: 556   Total Pages: 28   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85248321]
IC50_Mean 0.596SAR analysis of compounds that inhibit HePTP - Set 2 [AID449736, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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2
[SID85248321]
IC50_Mean 0.819MOA HePTP Fluorescent secondary assay for identification of redox-state modulating compounds [AID2068, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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3
[SID85248321]
IC50_Mean 1.195Fluorescent secondary assay for dose-response confirmation of chemical inhibitors of HePTP [AID1077, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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4
[SID47199189]
IC50 2.503Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay [AID540297, Type: confirmatory]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
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5
[SID85248321]
IC50_Mean 2.79SAR Selectivity Analysis of small molecule inhibitors of PEST using pCAP in a fluorescence assay [AID488884, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 12 isoform 2 [Homo sapiens] [gi:196114967]
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6
[SID85248321]
IC50_Mean 3.55SAR VHR1 Fluorescent Assay for In Vitro dose response studies Set 2 [AID2684, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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7
[SID85248321]
IC50_Mean 3.95SAR LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies - Set 3 [AID449726, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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8
[SID85248321]
IC50_Mean 4.09SAR LYP1 Fluorescent Assay using pCAP substrate for In Vitro dose response studies - Set 3 [AID449727, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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9
[SID47199189]
Potency 5.7988qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:115503961]
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10
[SID47199189]
IC50 6.608Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID651680, Type: confirmatory]arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2 [Homo sapiens] [gi:351542238]
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11
[SID47199189]
Potency 7.5193qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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12
[SID47199189]
IC50 8.11AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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13
[SID47199189]
IC50 8.11AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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14
[SID47199189]
IC50 8.11AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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15
[SID47199189]
IC50 13.55uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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16
[SID47199189]
IC50 13.55uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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17
[SID47199189]
IC50 13.55uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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18
[SID47199189]
Potency 15.104qHTS for Inhibitors of the Phosphatase Activity of Eya2: Carboxyl-terminal binding protein (CtBP) Counterscreen for Cherry-picked Compounds [AID720541, Type: confirmatory]C-terminal-binding protein 1 [gi:6014741]
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19
[SID85248321]
IC50_Mean 17.8In Vitro MKP-3 Dose Response Assay for SAR Study [AID1055, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
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20
[SID47199189]
Potency 19.0148qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds [AID720540, Type: confirmatory]eyes absent homolog 2 isoform a [Homo sapiens] [gi:26667227]
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