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Ro 08-2750 (CID 17756791) - Compound BioActivity Data
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BioActivity Outcomes:
Active(13)
 
 
Inactive(38)
 
 
Inconclusive(9)
 
 
Top Targets:
HELICc(3)
 
 
RIP(2)
 
 
NR LBD TR(2)
 
 
Tubulin-bindi..(2)
 
 
Peptidase C1A(2)
 
 
 
BioAssay Types:
Confirmatory(46)
 
 
 
 
Screening(12)
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(43)
 
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 55    Data Row: 60   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID163336475]
IC50 1Inhibition of NGF binding to p75NTR [AID700919, Type: Literature]
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2
[SID29215523]
Potency 3.1623qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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3
[SID163336475]
IC50 3.5Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 mins [AID765294, Type: Literature]Tyrosyl-DNA phosphodiesterase 2 [gi:67462008]
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4
[SID29215523]
Potency 6.3096Counterscreen for RECQ1 Inhibitors: ADP Fluorescence Polarization Displacement Assay [AID2711, Type: confirmatory]
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5
[SID29215523]
Potency 6.3096Counterscreen for BLMA Inhibitors: ADP Fluorescence Polarization Displacement Assay [AID2712, Type: confirmatory]
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6
[SID29215523]
Potency 10qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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7
[SID29215523]
Potency 15.8489qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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8
[SID29215523]
Potency 28.1838qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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9
[SID85788186]
SMM c-myc Measured in Biochemical System Using Small Molecule MicroArray - 2081-01_Other_SinglePoint_HTS_Activity [AID624141, Type: screening]myc proto-oncogene protein [Homo sapiens] [gi:71774083]
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10
[SID29215523]
Potency Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2708, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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11
[SID29215523]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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12
[SID29215523]
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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13
[SID29215523]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 [Homo sapiens] [gi:33946324]
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14
[SID29215523]
Potency 10qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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15
[SID29215523]
Potency 28.1838qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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16
[SID29215523]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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17
[SID29215523]
Potency qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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18
[SID29215523]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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19
[SID29215523]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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20
[SID85788186]
Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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