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Phenytoin (CID 1775) - Compound BioActivity Data
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BioActivity Outcomes:
Active(120)
 
 
Inactive(1754)
 
 
Inconclusive(103)
 
 
Unspecified(2707)
 
 
Top Targets:
7tm 4(87)
 
 
 
 
Na trans asso..(50)
 
 
 
NR LBD PPAR(40)
 
 
 
p450(34)
 
 
 
 
 
NR LBD ER(28)
 
 
 
 
BioAssay Types:
Literature(1418)
 
 
 
 
 
Confirmatory(996)
 
 
 
 
 
Screening(541)
 
 
 
 
 
Summary(73)
 
 
 
BioActivity Types:
Potency(818)
 
 
 
 
 
IC50(204)
 
 
 
 
 
Ki(35)
 
 
 
EC50(7)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 4018    Data Row: 4684   Total Pages: 235   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164546]
IC50 0.86Apparent IC50 value by [3H]batrachotoxinin-A-20-alpha-benzoate-binding test performed in rat brain synaptosomes [AID205272, Type: Literature]
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2
[SID103164546]
Ki 6Binding affinity towards cytochrome P450 2C9 [AID54410, Type: Literature]
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3
[SID103164546]
IC50 9.8Inhibition of human aquaporin 4 M23 isoform expressed in Xenopus laevis oocytes [AID409601, Type: Literature]
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4
[SID103164546]
Ki 10Binding affinity was measured on Cytochrome P450 2C9 [AID54403, Type: Literature]
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5
[SID103164546]
IC50 18.5Inhibition of [3H]BTX binding to guinea pig voltage-dependent sodium channel [AID71428, Type: Literature]
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6
[SID103164546]
IC50 21Inhibition of veratridine-induced guanidine flux in cardiac voltage-gated sodium channel (veratridine block vs. Na release) [AID217929, Type: Literature]
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7
[SID103164546]
IC50 22Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-clamp technique [AID471864, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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8
[SID103164546]
IC50 22Inhibition of rat Nav1.2 expressed in CHL1610 cells at -67 to -107 mV after 2 to 3 mins by whole-cell patch-clamp assay [AID1058310, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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9
[SID103164546]
Ki 24Affinity for inactive human SkM1 sodium channel expressed in HEK293 cells [AID205290, Type: Literature]Sodium channel protein type 4 subunit alpha [gi:292495096]
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10
[SID124886706]
Potency 34.3762qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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11
[SID26753028]
Potency-Replicate_1 35.4813qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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12
[SID103164546]
IC50 40Inhibition of [3H]BTX binding to cardiac voltage-gated sodium channel [AID217926, Type: Literature]
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13
[SID103164546]
IC50 40Inhibition of [3H]BTX-B binding to Neuronal voltage-dependent sodium channel of rat cerebral cortex synaptoneurosomes [AID146291, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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14
[SID103164546]
IC50 40Inhibition of binding to sodium channel of rat cerebral cortex [AID205277, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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15
[SID103164546]
IC50 40Inhibition of [3H]BTX-B binding to neurotoxin site 2 of sodium channel of rat cerebral cortex synaptoneurosomes [AID217794, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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16
[SID103164546]
IC50 40In vitro inhibition of Voltage-gated sodium channel by the displacement of [3H]batrachotoxin A 20-alpha-benzoate in rat brain cerebral cortex synaptoneurosomes [AID217796, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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17
[SID103164546]
IC50 40Inhibition of [3H]BTX-B binding to Neuronal voltage-dependent sodium channel of rat cerebral cortex synaptoneurosomes [AID146291, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
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18
[SID103164546]
IC50 40Inhibition of binding to sodium channel of rat cerebral cortex [AID205277, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
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19
[SID103164546]
IC50 40Inhibition of [3H]BTX-B binding to neurotoxin site 2 of sodium channel of rat cerebral cortex synaptoneurosomes [AID217794, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
View
20
[SID103164546]
IC50 40In vitro inhibition of Voltage-gated sodium channel by the displacement of [3H]batrachotoxin A 20-alpha-benzoate in rat brain cerebral cortex synaptoneurosomes [AID217796, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
View