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Phenytoin (CID 1775) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(89)
 
 
Inactive(1677)
 
 
Inconclusive(104)
 
 
Unspecified(2508)
 
 
Top Targets:
7TM GPCR Srx(47)
 
 
 
 
7TM GPCR Srsx(40)
 
 
 
NR LBD PPAR(40)
 
 
 
Na trans asso..(38)
 
 
 
p450(34)
 
 
 
 
 
BioAssay Types:
Literature(1267)
 
 
 
 
 
Confirmatory(876)
 
 
 
 
 
Screening(538)
 
 
 
 
 
Summary(73)
 
 
 
BioActivity Types:
Potency(813)
 
 
 
 
 
IC50(202)
 
 
 
 
 
Ki(34)
 
 
 
EC50(7)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3738    Data Row: 4378   Total Pages: 88   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164546]
IC50 0.86Apparent IC50 value by [3H]batrachotoxinin-A-20-alpha-benzoate-binding test performed in rat brain synaptosomes [AID205272, Type: Literature]
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2
[SID103164546]
Ki 6Binding affinity towards cytochrome P450 2C9 [AID54410, Type: Literature]
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3
[SID103164546]
IC50 9.8Inhibition of human aquaporin 4 M23 isoform expressed in Xenopus laevis oocytes [AID409601, Type: Literature]
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4
[SID103164546]
Ki 10Binding affinity was measured on Cytochrome P450 2C9 [AID54403, Type: Literature]
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5
[SID103164546]
IC50 18.5Inhibition of [3H]BTX binding to guinea pig voltage-dependent sodium channel [AID71428, Type: Literature]
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6
[SID103164546]
IC50 21Inhibition of veratridine-induced guanidine flux in cardiac voltage-gated sodium channel (veratridine block vs. Na release) [AID217929, Type: Literature]
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7
[SID103164546]
IC50 22Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-clamp technique [AID471864, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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8
[SID103164546]
Ki 24Affinity for inactive human SkM1 sodium channel expressed in HEK293 cells [AID205290, Type: Literature]Sodium channel protein type 4 subunit alpha [gi:292495096]
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9
[SID124886706]
Potency 34.3762qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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10
[SID26753028]
Potency-Replicate_1 35.4813qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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11
[SID103164546]
IC50 40In vitro inhibition of Voltage-gated sodium channel by the displacement of [3H]batrachotoxin A 20-alpha-benzoate in rat brain cerebral cortex synaptoneurosomes [AID217796, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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12
[SID103164546]
IC50 40Inhibition of [3H]BTX-B binding to neurotoxin site 2 of sodium channel of rat cerebral cortex synaptoneurosomes [AID217794, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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13
[SID103164546]
IC50 40Inhibition of [3H]BTX-B binding to Neuronal voltage-dependent sodium channel of rat cerebral cortex synaptoneurosomes [AID146291, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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14
[SID103164546]
IC50 40Inhibition of binding to sodium channel of rat cerebral cortex [AID205277, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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15
[SID103164546]
IC50 40In vitro inhibition of Voltage-gated sodium channel by the displacement of [3H]batrachotoxin A 20-alpha-benzoate in rat brain cerebral cortex synaptoneurosomes [AID217796, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
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16
[SID103164546]
IC50 40Inhibition of binding to sodium channel of rat cerebral cortex [AID205277, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
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17
[SID103164546]
IC50 40Inhibition of [3H]BTX-B binding to neurotoxin site 2 of sodium channel of rat cerebral cortex synaptoneurosomes [AID217794, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
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18
[SID103164546]
IC50 40Inhibition of [3H]BTX-B binding to Neuronal voltage-dependent sodium channel of rat cerebral cortex synaptoneurosomes [AID146291, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
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19
[SID103164546]
IC50 40Inhibition of binding to sodium channel of rat cerebral cortex [AID205277, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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20
[SID103164546]
IC50 40Inhibition of [3H]BTX-B binding to neurotoxin site 2 of sodium channel of rat cerebral cortex synaptoneurosomes [AID217794, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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21
[SID103164546]
IC50 40Inhibition of [3H]BTX-B binding to Neuronal voltage-dependent sodium channel of rat cerebral cortex synaptoneurosomes [AID146291, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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22
[SID103164546]
IC50 40In vitro inhibition of Voltage-gated sodium channel by the displacement of [3H]batrachotoxin A 20-alpha-benzoate in rat brain cerebral cortex synaptoneurosomes [AID217796, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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23
[SID103164546]
IC50 40Displacement of [3H]batrachotoxin from neurotoxin site 2 of voltage-gated sodium channel in rat forebrain tissue [AID514957, Type: Literature]
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24
[SID103164546]
IC50 40In vitro inhibition of [3H]-BTX-B binding to sodium channels in rat brain synapto-neurosomes [AID205274, Type: Literature]
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25
[SID103164546]
IC50 40Inhibition of [3H]BTX binding to cardiac voltage-gated sodium channel [AID217926, Type: Literature]
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26
[SID103164546]
IC50 40Displacement of [3H]-BTX-B from neuronal voltage-gated sodium channel in rat cerebral cortex synaptoneurosomes [AID450269, Type: Literature]
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27
[SID144209497]
Potency-Replicate_1 48.163qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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28
[SID144209497]
Potency-Replicate_1 60.6336qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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29
[SID144210601]
Potency-Replicate_1 61.1306qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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30
[SID103164546]
Anticonvulsant activity in Kunming mouse assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, ip measured after 0.5 hr [AID666664, Type: Literature]
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31
[SID103164546]
Anticonvulsant activity in Kunming mouse assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, ip measured after 4 hrs [AID666668, Type: Literature]
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32
[SID103164546]
Anticonvulsant effect in Sprague-Dawley rat epileptic model assessed as increase in seizure thresholds at 50 mg/kg, po dosed before seizure induction by maximal electroshock test [AID678126, Type: Literature]
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33
[SID103164546]
Anticonvulsant effect in Sprague-Dawley rat epileptic model assessed as increase in seizure thresholds at 50 mg/kg, po dosed before seizure induction by subcutaneous metrazol seizure threshold test [AID678127, Type: Literature]
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34
[SID103164546]
Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis [AID678721, Type: Literature]
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35
[SID48413692]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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36
[SID11532994]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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37
[SID103164546]
Anticonvulsant activity against electric stimulation-induced pharmacoresistant limbic epilepsy in ip dosed Sprague-Dawley rat kindling model assessed as reduction of seizure severity and excitability administered 15 mins after last electric stimulation measured after 15 mins to 1 hr [AID471590, Type: Literature]
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38
[SID103164546]
Anticonvulsant activity in Sprague-Dawley albino rat assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, po after 0.5 hrs [AID623176, Type: Literature]
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39
[SID103164546]
Anticonvulsant activity in mouse assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, ip after 0.5 hrs [AID682342, Type: Literature]
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40
[SID103164546]
Anticonvulsant activity in mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip after 0.5 hrs [AID682343, Type: Literature]
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41
[SID103164546]
Anticonvulsant activity in mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip after 0.5 hrs [AID682344, Type: Literature]
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42
[SID103164546]
Anticonvulsant activity in mouse assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, ip after 4 hrs [AID682345, Type: Literature]
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43
[SID103164546]
Anticonvulsant activity in mouse assessed as protection against maximal electroshock-induced seizures at 100 mg/kg, ip after 4 hrs [AID682346, Type: Literature]
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44
[SID103164546]
Anticonvulsant activity in mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip after 4 hrs [AID682347, Type: Literature]
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45
[SID103164546]
Anticonvulsant activity in CF1 albino mouse assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, po after 0.5 hrs [AID372929, Type: Literature]
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46
[SID103164546]
Anticonvulsant activity in Sprague-Dawley rat assessed as protection against seizure at 30 mg/kg, po after 0.5 hr by maximal electroshock test [AID382187, Type: Literature]
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47
[SID103164546]
Anticonvulsant activity in Swiss Albino mouse at 30 mg/kg, ip after 0.5 hr by MES test [AID286839, Type: Literature]
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48
[SID103164546]
Anticonvulsant activity in Swiss Albino mouse at 30 mg/kg, ip after 4 hrs by MES test [AID286841, Type: Literature]
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49
[SID103164546]
Neurotoxicity in Swiss Albino mouse at 100 mg/kg, ip after 0.5 hr by rotarod test [AID286855, Type: Literature]
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50
[SID103164546]
Neurotoxicity in Swiss Albino mouse at 100 mg/kg, ip after 4 hrs by rotarod test [AID286857, Type: Literature]
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