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erlotinib (CID 176870) - Compound BioActivity Data
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BioActivity Outcomes:
Active(574)
 
 
Inactive(431)
 
 
Inconclusive(82)
 
 
Unspecified(1719)
 
 
Top Targets:
PKc(96)
 
 
 
 
PKc like(80)
 
 
 
 
 
PTKc EGFR(63)
 
 
 
 
 
STKc AGC(46)
 
 
 
 
PTKc Abl(40)
 
 
 
 
BioAssay Types:
Literature(1998)
 
 
 
 
 
Confirmatory(535)
 
 
 
 
 
Summary(25)
 
 
 
 
Screening(8)
 
 
 
BioActivity Types:
Kd(885)
 
 
 
 
IC50(539)
 
 
 
 
 
Potency(149)
 
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2501    Data Row: 2806   Total Pages: 141   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177459]
IC50 0.0001Inhibition of EGFR Leu858Arg mutant by HTRF assay [AID473322, Type: Literature]
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2
[SID103177459]
IC50 0.0002Inhibition of wild type EGFR by HTRF assay [AID473321, Type: Literature]
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3
[SID103177459]
Kd 0.00035Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID435906, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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4
[SID103177459]
Kd 0.00035Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID625002, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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5
[SID103177459]
IC50 0.0004Inhibition of EGFR [AID383062, Type: Literature]
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6
[SID103177459]
Kd 0.00047Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID625001, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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7
[SID103177459]
Kd 0.00047Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID435653, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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8
[SID103177459]
Kd 0.00048Binding constant for EGFR(E746-A750del) kinase domain [AID435791, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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9
[SID103177459]
Kd 0.00048Binding constant for EGFR(E746-A750del) kinase domain [AID624997, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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10
[SID103177459]
Kd 0.00052Binding constant for EGFR(G719S) kinase domain [AID624999, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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11
[SID103177459]
Kd 0.00052Binding constant for EGFR(L747-E749del, A750P) kinase domain [AID625000, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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12
[SID103177459]
Kd 0.00052Binding constant for EGFR(G719S) kinase domain [AID435402, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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13
[SID103177459]
Kd 0.00052Binding constant for EGFR(L747-E749del, A750P) kinase domain [AID435652, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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14
[SID103177459]
IC50 0.0006Inhibition of erbB1 fusion protein expressed in baculovirus by ELISA [AID260895, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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15
[SID103177459]
Kd 0.00067Binding constant for EGFR kinase domain [AID435156, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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16
[SID103177459]
Kd 0.00067Binding constant for EGFR kinase domain [AID624996, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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17
[SID26757996]
Potency 0.0008Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay: EGFR Kinase Inhibition [AID1731, Type: confirmatory]epidermal growth factor receptor isoform a precursor [Homo sapiens] [gi:29725609]
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18
[SID103177459]
Kd 0.00085Binding constant for EGFR(G719C) kinase domain [AID624998, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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19
[SID103177459]
Kd 0.00085Binding constant for EGFR(G719C) kinase domain [AID435157, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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20
[SID26757996]
Potency 0.0009Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay: EGFR L858R Kinase Inhibition [AID1727, Type: confirmatory]epidermal growth factor receptor isoform a precursor [Homo sapiens] [gi:29725609]
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