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SB 203580 (CID 176155) - Compound BioActivity Data
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BioActivity Outcomes:
Active(394)
 
 
Inactive(508)
 
 
Inconclusive(39)
 
 
Unspecified(1471)
 
 
Top Targets:
PKc like(162)
 
 
 
 
PKc(157)
 
 
 
 
STKc AGC(74)
 
 
 
STKc p38alpha..(46)
 
 
 
 
p450(39)
 
 
 
 
BioAssay Types:
Literature(1442)
 
 
 
 
 
Confirmatory(278)
 
 
 
 
Screening(16)
 
 
 
BioActivity Types:
Kd(887)
 
 
 
 
IC50(304)
 
 
 
 
Potency(184)
 
 
 
 
EC50(4)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1969    Data Row: 2412   Total Pages: 49   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103163913]
Kd 0.0041Binding affinity to full-length GST-tagged p38alpha by surface plasmon resonance assay [AID516348, Type: Literature]
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2
[SID103163913]
IC50 0.01Inhibitory concentration against alpha mitogen activated protein kinase p38 activity [AID241741, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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3
[SID103163913]
Kd 0.01Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay [AID127076, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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4
[SID103163913]
Kd 0.01Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay [AID127076, Type: Literature]Mitogen-activated protein kinase 12 [gi:2851522]
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5
[SID103163913]
Kd 0.01Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay [AID127076, Type: Literature]Mitogen-activated protein kinase 13 [gi:6685642]
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6
[SID103163913]
Kd 0.01Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay [AID127076, Type: Literature]Mitogen-activated protein kinase 11 [gi:134047835]
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7
[SID103163913]
Kd 0.012Binding constant for p38-alpha kinase domain [AID624714, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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8
[SID103163913]
Kd 0.012Binding constant for full-length p38-alpha [AID435181, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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9
[SID103163913]
IC50 0.015Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assay [AID596311, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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10
[SID103163913]
IC50 0.016Inhibition of LPS-induced TNFalpha production in human THP1 cells [AID322017, Type: Literature]
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11
[SID103163913]
IC50 0.016Inhibition of human receptor-interacting serine-threonine kinase 2 (RIPK2) at 100 uM ATP [AID242591, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
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12
[SID103163913]
Kd 0.017Average Binding Constant for p38-alpha ; NA=Not Active at 10 uM [AID256656, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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13
[SID103163913]
Kd 0.019Binding constant for GAK kinase domain [AID625012, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
View
14
[SID103163913]
Kd 0.019Binding constant for GAK kinase domain [AID435821, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
View
15
[SID103163913]
IC50 0.02Concentration required to inhibit human mitogen activated protein kinase p38 activity [AID241747, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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16
[SID103163913]
Kd 0.02Kd value and murine Mitogen-activated protein kinase p38 alpha complex was calculated [AID127268, Type: Literature]
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17
[SID103163913]
IC50 0.02In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from Escherichia coli [AID127407, Type: Literature]
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18
[SID103163913]
IC50 0.02Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 [AID127410, Type: Literature]
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19
[SID103163913]
IC50 0.02Inhibition of mitogen-activated protein kinase p38 alpha 2 [AID127411, Type: Literature]
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20
[SID103163913]
IC50 0.02Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in Escherichia coli. [AID127412, Type: Literature]
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21
[SID103163913]
Kd 0.024Binding constant for RIPK2 kinase domain [AID435935, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
View
22
[SID103163913]
Kd 0.024Binding constant for RIPK2 kinase domain [AID624925, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
View
23
[SID103163913]
IC50 0.025Inhibition of TNF-alpha production by lipopolysaccharide-stimulated human peripheral blood mononuclear cells [AID222608, Type: Literature]Mitogen-activated protein kinase 11 [gi:134047835]
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24
[SID103163913]
Kd 0.025Binding constant for NLK kinase domain [AID625100, Type: Literature]Serine/threonine-protein kinase NLK [gi:262527551]
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25
[SID103163913]
Kd 0.025Binding constant for full-length NLK [AID435667, Type: Literature]Serine/threonine-protein kinase NLK [gi:262527551]
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26
[SID103163913]
IC50 0.025Inhibition of LPS-stimulated TH+NF-alphs production by human peripheral blood mononuclear cells (PBMCs) [AID215078, Type: Literature]
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27
[SID103163913]
IC50 0.025Inhibition of TNF-alpha production by lipopolysaccharide-stimulated human peripheral blood mononuclear cells [AID222608, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
View
28
[SID103163913]
IC50 0.025Inhibition of TNF-alpha production by lipopolysaccharide-stimulated human peripheral blood mononuclear cells [AID222608, Type: Literature]Mitogen-activated protein kinase 13 [gi:6685642]
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29
[SID103163913]
IC50 0.025Inhibition of TNF-alpha production by lipopolysaccharide-stimulated human peripheral blood mononuclear cells [AID222608, Type: Literature]Mitogen-activated protein kinase 12 [gi:2851522]
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30
[SID103163913]
IC50 0.03Inhibition of p38-alpha MAPK by non-radioactive immunosorbent assay [AID280500, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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31
[SID103163913]
IC50 0.034Inhibition of p38 MAP kinase [AID325676, Type: Literature]
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32
[SID103163913]
Kd 0.035Binding constant for JNK3 kinase domain [AID435293, Type: Literature]Mitogen-activated protein kinase 10 [gi:2507196]
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33
[SID103163913]
Kd 0.035Binding constant for JNK3 kinase domain [AID624891, Type: Literature]Mitogen-activated protein kinase 10 [gi:2507196]
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34
[SID103163913]
IC50 0.037Inhibition of p38 MAP kinase related TNF-alpha release from peripheral blood mononuclear cells (PBMC) [AID127070, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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35
[SID103163913]
IC50 0.037Inhibition of p38 MAP kinase related TNF-alpha release from peripheral blood mononuclear cells (PBMC) [AID127070, Type: Literature]Mitogen-activated protein kinase 12 [gi:2851522]
View
36
[SID103163913]
IC50 0.037Inhibition of p38 MAP kinase related TNF-alpha release from peripheral blood mononuclear cells (PBMC) [AID127070, Type: Literature]Mitogen-activated protein kinase 13 [gi:6685642]
View
37
[SID103163913]
IC50 0.037Inhibition of p38 kinase at 2 uM [AID223814, Type: Literature]
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38
[SID103163913]
IC50 0.037Inhibitory activity against induction of IL-1-beta release in PBMCs [AID152778, Type: Literature]
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39
[SID103163913]
IC50 0.037Inhibition of the release of interleukin-1-beta from peripheral blood mononuclear cells [AID155131, Type: Literature]
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40
[SID103163913]
IC50 0.037Inhibition of MAP kinase p38alpha assessed as phosphorylation of ATF-2 [AID706189, Type: Literature]
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41
[SID103163913]
IC50 0.037Inhibition of p38 MAP kinase related TNF-alpha release from peripheral blood mononuclear cells (PBMC) [AID127070, Type: Literature]Mitogen-activated protein kinase 11 [gi:134047835]
View
42
[SID103163913]
Kd 0.037Binding constant for full-length CSNK1D [AID435524, Type: Literature]Casein kinase I isoform delta [gi:27923980]
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43
[SID103163913]
Kd 0.037Binding constant for CSNK1D kinase domain [AID624716, Type: Literature]Casein kinase I isoform delta [gi:27923980]
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44
[SID103163913]
IC50 0.038Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha. [AID126603, Type: Literature]
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45
[SID103163913]
IC50 0.038Inhibition of Mitogen-activated protein kinase 14 (P38 alpha) at 100 uM ATP [AID242399, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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46
[SID103163913]
IC50 0.039Inhibition of human p38-alpha kinase [AID322018, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
View
47
[SID103163913]
IC50 0.039Inhibition of Mitogen-activated protein kinase p38 [AID127243, Type: Literature]
View
48
[SID103163913]
IC50 0.039Inhibition of Mitogen-activated protein kinase p38 alpha [AID127272, Type: Literature]
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49
[SID103163913]
IC50 0.039Inhibition of p38 alpha activity by ELISA [AID495020, Type: Literature]
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50
[SID103163913]
Kd 0.039Average Binding Constant for GAK ; NA=Not Active at 10 uM [AID256612, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
View