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SB 203580 (CID 176155) - Compound BioActivity Data
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BioActivity Outcomes:
Active(414)
 
 
Inactive(512)
 
 
Inconclusive(39)
 
 
Unspecified(1477)
 
 
Top Targets:
PKc like(162)
 
 
 
 
PKc(157)
 
 
 
 
STKc AGC(74)
 
 
 
STKc p38alpha..(50)
 
 
 
 
p450(39)
 
 
 
 
BioAssay Types:
Literature(1988)
 
 
 
 
 
Confirmatory(400)
 
 
 
 
 
Screening(16)
 
 
 
BioActivity Types:
Kd(887)
 
 
 
 
IC50(314)
 
 
 
 
Potency(189)
 
 
 
 
EC50(4)
 
 
Ki(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1997    Data Row: 2442   Total Pages: 123   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID46392883]
Ki 0.0004Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Structure Of Penta Mutant Human Erk2 Map Kinase Complexed With A Specific Inhibitor Of Human P38 Map Kinase [gi:157833528]
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2
[SID46392883]
Ki 0.0004Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Structure Of Penta Mutant Human Erk2 Map Kinase Complexed With A Specific Inhibitor Of Human P38 Map Kinase [gi:157833528]
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3
[SID103163913]
Kd 0.0041Binding affinity to full-length GST-tagged p38alpha by surface plasmon resonance assay [AID516348, Type: Literature]
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4
[SID103163913]
Kd 0.01Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay [AID127076, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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5
[SID103163913]
IC50 0.01Inhibitory concentration against alpha mitogen activated protein kinase p38 activity [AID241741, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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6
[SID103163913]
Kd 0.01Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay [AID127076, Type: Literature]Mitogen-activated protein kinase 12 [gi:2851522]
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7
[SID103163913]
Kd 0.01Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay [AID127076, Type: Literature]Mitogen-activated protein kinase 13 [gi:6685642]
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8
[SID103163913]
Kd 0.01Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay [AID127076, Type: Literature]Mitogen-activated protein kinase 11 [gi:134047835]
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9
[SID103163913]
Kd 0.012Binding constant for full-length p38-alpha [AID435181, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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10
[SID103163913]
Kd 0.012Binding constant for p38-alpha kinase domain [AID624714, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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11
[SID103163913]
IC50 0.015Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assay [AID596311, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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12
[SID103163913]
IC50 0.016Inhibition of human receptor-interacting serine-threonine kinase 2 (RIPK2) at 100 uM ATP [AID242591, Type: Literature]Receptor-interacting serine/threonine-protein kinase 2 [gi:20455217]
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13
[SID103163913]
IC50 0.016Inhibition of LPS-induced TNFalpha production in human THP1 cells [AID322017, Type: Literature]
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14
[SID103163913]
Kd 0.017Average Binding Constant for p38-alpha; NA=Not Active at 10 uM [AID256656, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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15
[SID103163913]
Kd 0.019Binding constant for GAK kinase domain [AID435821, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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16
[SID103163913]
Kd 0.019Binding constant for GAK kinase domain [AID625012, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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17
[SID103163913]
IC50 0.02Concentration required to inhibit human mitogen activated protein kinase p38 activity [AID241747, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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18
[SID103163913]
Kd 0.02Kd value and murine Mitogen-activated protein kinase p38 alpha complex was calculated [AID127268, Type: Literature]
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19
[SID103163913]
IC50 0.02In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from Escherichia coli [AID127407, Type: Literature]
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20
[SID103163913]
IC50 0.02Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 [AID127410, Type: Literature]
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