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1,5-dideoxy-1,5-iminogalactitol (CID 176077) - Compound BioActivity Data
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BioActivity Outcomes:
Active(18)
 
 
Inactive(95)
 
 
Inconclusive(6)
 
 
Unspecified(50)
 
 
Top Targets:
p450(9)
 
 
PLN02808(8)
 
 
 
 
GH31 MGAM SI..(6)
 
 
 
 
HSD10-like SD..(4)
 
 
Glyco hydro 3..(3)
 
 
BioAssay Types:
Confirmatory(96)
 
 
 
 
Literature(61)
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(76)
 
 
 
 
IC50(17)
 
 
 
Ki(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 159    Data Row: 169   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103329495]
IC50 0.003Inhibitory concentration against alpha-galactosidase of coffee bean [AID241236, Type: Literature]
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2
[SID103329495]
IC50 0.003Inhibition of coffee bean alpha-galactosidase assessed as p-nitrophenol release at pH 6.5 by spectrometric analysis [AID488404, Type: Literature]Alpha-galactosidase [gi:2492782]
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3
[SID103329495]
Ki 0.013Inhibition of alpha-galactosidase green coffee beans [AID489426, Type: Literature]Alpha-galactosidase [gi:2492782]
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4
[SID103329495]
IC50 0.07Inhibition of human lysosome alpha-galactosidase assessed as p-nitrophenol release by spectrometric analysis [AID488405, Type: Literature]Alpha-galactosidase A [gi:113499]
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5
[SID103329495]
IC50 0.07Inhibitory concentration against human alpha-galactosidase [AID240937, Type: Literature]Alpha-galactosidase A [gi:113499]
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6
[SID11114003]
Potency 0.0823qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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7
[SID103329495]
IC50 0.26Inhibition of sucrase by HPLC [AID466667, Type: Literature]
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8
[SID11114003]
Potency 1.422qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Primary Screen Confirmation [AID2590, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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9
[SID11114003]
Potency 1.422qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease: Hit Validation [AID2671, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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10
[SID103329495]
IC50 1.5Inhibition of maltase by HPLC [AID466668, Type: Literature]
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11
[SID103329495]
IC50 1.8Inhibitory concentration against alpha-galactosidase of Aspergillus niger [AID241411, Type: Literature]Alpha-galactosidase C [gi:24636246]
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12
[SID11114003]
Potency 5.0119qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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13
[SID103329495]
IC50 6Inhibition of lysosomal alpha-glucosidase by HPLC [AID466672, Type: Literature]
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14
[SID103329495]
IC50 10Inhibition of glycogen glycogen de-branching enzyme by HPLC [AID466673, Type: Literature]
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15
[SID11114003]
Potency 10qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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16
[SID103329495]
Ki 12.5Inhibition of Agrobacterium sp. beta-galactosidase [AID263088, Type: Literature]
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17
[SID103329495]
Ki 13Inhibition of Escherichia coli beta-galactosidase [AID489425, Type: Literature]
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18
[SID103329495]
IC50 24Inhibitory concentration against beta-galactosidase of rat [AID240929, Type: Literature]
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19
[SID103329495]
IC50 50Inhibition of lactase by HPLC [AID466669, Type: Literature]
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20
[SID103329495]
IC50 72Inhibition of rat intestinal lactase assessed as p-nitrophenol release by spectrometric analysis [AID488407, Type: Literature]Lactase-phlorizin hydrolase [gi:6648054]
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21
[SID103329495]
IC50 90Inhibitory concentration against human beta-galactosidase [AID240897, Type: Literature]Beta-galactosidase [gi:215273939]
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22
[SID103329495]
Ki 100Inhibition of Agrobacterium sp. beta galactosidase [AID411656, Type: Literature]
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23
[SID103329495]
IC50 100Inhibition of GCS by cell-based assay [AID466666, Type: Literature]
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24
[SID103329495]
IC50 100Inhibition of GBA2 by HPLC [AID466671, Type: Literature]
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25
[SID103329495]
Ki 100Inhibition of Agrobacterium sp. beta-glucosidase [AID489424, Type: Literature]
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26
[SID103329495]
IC50 350Inhibition of GBA1 by HPLC [AID466670, Type: Literature]
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27
[SID103329495]
IC50 367Inhibition of Caldocellum saccharolyticum beta-glucosidase assessed as p-nitrophenol release at pH 5 by spectrometric analysis [AID488402, Type: Literature]Beta-glucosidase A [gi:114969]
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28
[SID103329495]
Ki 34000Inhibition constant against Alpha-Fucosidase [AID36831, Type: other]
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29
[SID11114003]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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30
[SID103329495]
Inhibition of Aspergillus niger amyloglucosidase assessed as p-nitrophenol release at 1000 uM at pH 4.5 by spectrometric analysis [AID488412, Type: Literature]
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31
[SID103329495]
Inhibition of bovine liver beta-galactosidase assessed as p-nitrophenol release at 1000 uM by spectrometric analysis [AID488413, Type: Literature]
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32
[SID103329495]
Inhibition of yeast alpha-glucosidase assessed as p-nitrophenol release at 1000 uM at pH 6.8 by spectrometric analysis [AID488414, Type: Literature]
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33
[SID103329495]
Inhibition of rice alpha-glucosidase assessed as D-glucose release at 1000 uM at pH 5 after 10 to 30 mins [AID488415, Type: Literature]
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34
[SID103329495]
Inhibition of rat intestinal maltase assessed as D-glucose release at 1000 uM at pH 5.8 after 10 to 30 mins [AID488416, Type: Literature]
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35
[SID103329495]
Inhibition of almond beta-glucosidase assessed as p-nitrophenol release at 1000 uM at pH 5 by spectrometric analysis [AID488417, Type: Literature]
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36
[SID103329495]
Inhibition of bovine liver beta-glucosidase assessed as p-nitrophenol release at 1000 uM at pH 6.8 by spectrometric analysis [AID488419, Type: Literature]
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37
[SID103329495]
Inhibition of jack bean alpha-mannosidase assessed as p-nitrophenol release at 1000 uM at pH 4.5 by spectrometric analysis [AID488423, Type: Literature]
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38
[SID103329495]
Percent inhibition of alpha-glucosidase of rice 1000 uM [AID243664, Type: Literature]
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39
[SID103329495]
Percent inhibition of beta-glucosidase of almond tree at 1000 uM [AID243694, Type: Literature]
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40
[SID103329495]
Percent inhibition of beta-galactosidase of bovine liver at 1000 uM [AID243726, Type: Literature]
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41
[SID103329495]
Percent inhibition of beta-mannosidase of rat epididymis at 1000 uM [AID243727, Type: Literature]
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42
[SID103329495]
Percent inhibition of alpha-mannosidase of jack bean tree at 1000 uM [AID243739, Type: Literature]
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43
[SID103329495]
Percent inhibition of alpha-mannosidase of rat epididymis 1000 uM [AID243740, Type: Literature]
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44
[SID103329495]
Percent inhibition of alpha-L-fucosidase of bovine epididymis at 1000 uM [AID243762, Type: Literature]
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45
[SID103329495]
Induction of human beta galactosidase Y83H mutant activity expressed in beta galactosidase knock out mouse fibroblast at 500 uM relative to control [AID731134, Type: Literature]
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46
[SID103329495]
Induction of human beta galactosidase W273L mutant activity expressed in beta galactosidase knock out mouse fibroblast at 500 uM relative to control [AID731135, Type: Literature]
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47
[SID103329495]
Induction of human beta galactosidase R457Q mutant activity expressed in beta galactosidase knock out mouse fibroblast at 500 uM relative to control [AID731136, Type: Literature]
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48
[SID103329495]
Induction of human beta galactosidase R201H mutant activity expressed in beta galactosidase knock out mouse fibroblast at 500 uM relative to control [AID731137, Type: Literature]
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49
[SID103329495]
Induction of human beta galactosidase I51T mutant activity expressed in beta galactosidase knock out mouse fibroblast at 500 uM relative to control [AID731138, Type: Literature]
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50
[SID103329495]
Induction of human beta galactosidase R201C mutant activity expressed in beta galactosidase knock out mouse fibroblast at 500 uM relative to control [AID731139, Type: Literature]
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