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Acetic Acid (CID 176) - Compound BioActivity Data
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BioActivity Outcomes:
Active(13)
 
 
Inactive(97)
 
 
Inconclusive(2)
 
 
Unspecified(96)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD Fxr(4)
 
 
NR LBD GR(4)
 
 
BioAssay Types:
Literature(120)
 
 
 
 
Confirmatory(62)
 
 
 
Summary(24)
 
 
BioActivity Types:
Potency(80)
 
 
 
Kd(2)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 207    Data Row: 208   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176092]
Kd 0.64Dissociation constant for binding to SH2 domain of p56 lck tyrosine kinase [AID224294, Type: Literature]
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2
[SID103176092]
Kd 0.9Dissociation constant for binding to SH2 domain of Fyn protein kinase [AID72281, Type: Literature]
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3
[SID103176092]
Pre-emergence herbicidal activity against Lolium rigidum seeds assessed as seed germination at 0.1 mol/l at 25 degC after 72 hr by laboratory-based agar medium bioassay relative to 1,8-Cineole [AID1081607, Type: Literature]
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4
[SID103176092]
Pre-emergence herbicidal activity against Lolium rigidum seeds assessed as shoot length at 0.1 mol/l at 25 degC after 72 hr by laboratory-based agar medium bioassay relative to 1,8-Cineole [AID1081608, Type: Literature]
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5
[SID103176092]
Pre-emergence herbicidal activity against Lolium rigidum seeds assessed as root length at 0.1 mol/l at 25 degC after 72 hr by laboratory-based agar medium bioassay relative to 1,8-Cineole [AID1081609, Type: Literature]
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6
[SID103176092]
Pre-emergence herbicidal activity against Raphanus sativus var.Long scarlet (radish) seeds assessed as seed germination at 0.1 mol/l at 25 degC after 72 hr by laboratory-based agar medium bioassay relative to 1,8-Cineole [AID1081610, Type: Literature]
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7
[SID103176092]
Pre-emergence herbicidal activity against Raphanus sativus var.Long scarlet (radish) seeds assessed as shoot length at 0.1 mol/l at 25 degC after 72 hr by laboratory-based agar medium bioassay relative to 1,8-Cineole [AID1081611, Type: Literature]
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8
[SID103176092]
Pre-emergence herbicidal activity against Raphanus sativus var.Long scarlet (radish) seeds assessed as root length at 0.1 mol/l at 25 degC after 72 hr by laboratory-based agar medium bioassay relative to 1,8-Cineole [AID1081612, Type: Literature]
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9
[SID103176092]
Longevity-promoting activity in wild type Caenorhabditis elegans N2 assessed as increase in lifespan at 50 ppm by microscopic analysis [AID452626, Type: Literature]
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10
[SID103176092]
Longevity-promoting activity in wild type Caenorhabditis elegans N2 assessed as increase in DAF16 transcription factor mRNA expression at 50 ppm after 2 days by quantitative RT-PCR analysis [AID452627, Type: Literature]
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11
[SID103176092]
Longevity-promoting activity in wild type Caenorhabditis elegans N2 assessed as decrease in DAF2 receptor mRNA expression at 50 ppm after 2 days by quantitative RT-PCR analysis [AID452628, Type: Literature]
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12
[SID103176092]
Longevity-promoting activity in wild type Caenorhabditis elegans N2 assessed as increase in GFP-fused DAF16 transcription factor mRNA expression at 50 ppm by quantitative RT-PCR analysis [AID452647, Type: Literature]
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13
[SID103176092]
Nematotoxic activity against freshly hatched Meloidogyne incognita J2 (root-knot nematode) isolated from tomato roots assessed as induction of microscopic damages at 100 ug/mL measured 24 hr after immersion in compound test solutions [AID1083147, Type: Literature]
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14
[SID103176092]
LD50 10Cytotoxicity against mouse RAW264.7 cells [AID627981, Type: Literature]
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15
[SID103176092]
IC50 120Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production [AID454554, Type: Literature]Free fatty acid receptor 2 [gi:3122160]
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16
[SID103176092]
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production relative to acetate [AID454564, Type: Literature]Free fatty acid receptor 2 [gi:3122160]
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17
[SID103176092]
TP_TRANSPORTER: uptake (pH 7.4) of Acetic acid at a concentration of 4.94 u M in OATP-B-expressing HEK293 cells [AID679427, Type: Literature]Solute carrier organic anion transporter family member 2B1 [gi:313104012]
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18
[SID103176092]
TP_TRANSPORTER: uptake (pH 5.0) of Acetic acid at a concentration of 4.94 u M in OATP-B-expressing HEK293 cells [AID679436, Type: Literature]Solute carrier organic anion transporter family member 2B1 [gi:313104012]
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19
[SID103176092]
TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.00476 uM, acetic acid: 10000 uM) in OATP-B-expressing HEK293 cells [AID679446, Type: Literature]Solute carrier organic anion transporter family member 2B1 [gi:313104012]
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20
[SID103176092]
Pre-emergence herbicidal activity against Lolium rigidum seeds assessed as seed germination at 0.1 mol/l at 25 degC after 72 hr by laboratory-based agar medium bioassay relative to control [AID1081616, Type: Literature]
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