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SMR000194157 (CID 1746420) - Compound BioActivity Data
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BioActivity Outcomes:
Active(58)
 
 
Inactive(614)
 
 
Inconclusive(40)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
 
7TM GPCR Srsx(20)
 
 
 
Bcl-2 like(11)
 
 
 
Tryp SPc(10)
 
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(468)
 
 
 
 
 
Confirmatory(219)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(159)
 
 
 
 
 
IC50(47)
 
 
 
EC50(7)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 645    Data Row: 714   Total Pages: 36   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17433362]
Potency 0.5012qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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2
[SID17433362]
IC50 0.73674Counterscreen for NR2E3 inverse agonists: TR-FRET-based biochemical high throughput dose response assay to identify inverse agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) [AID463257, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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3
[SID17433362]
IC50 0.73674Counterscreen for NR2E3 inverse agonists: TR-FRET-based biochemical high throughput dose response assay to identify inverse agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) [AID463257, Type: confirmatory]nuclear receptor corepressor 2 isoform 2 [Homo sapiens] [gi:116256445]
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4
[SID17433362]
IC50 0.77416TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists [AID463256, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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5
[SID17433362]
Potency 0.7943qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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6
[SID17433362]
Potency 1.1668qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21 [AID2289, Type: confirmatory]
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7
[SID17433362]
Potency 2.3934qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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8
[SID17433362]
Potency 4.1095A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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9
[SID17433362]
Potency 6.3096qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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10
[SID17433362]
Potency 10qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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11
[SID17433362]
Potency 10.3225A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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12
[SID17433362]
Potency 10.3225qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID17433362]
Potency 12.5893VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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14
[SID17433362]
Potency 14.1254qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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15
[SID17433362]
Potency 15.8489qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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16
[SID17433362]
Potency 19.9526Inhibitors of DNA Polymerase Beta: Hit validation [AID540280, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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17
[SID17433362]
IC50 23.7Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay [AID602368, Type: confirmatory]PSMD14 protein [Homo sapiens] [gi:16306916]
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18
[SID17433362]
IC50 51.4Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay [AID602369, Type: confirmatory]TPA: prothrombin [Bos taurus] [gi:296479639]
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19
[SID17433362]
Potency 56.2341qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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20
[SID17433362]
Potency 67.0158qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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