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AmbscE-022676 (CID 17366663) - Compound BioActivity Data
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BioActivity Outcomes:
Active(25)
 
 
Inactive(503)
 
 
Inconclusive(21)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(15)
 
 
 
CAP ED(5)
 
 
TRP 2(5)
 
 
ANK(5)
 
 
 
 
BioAssay Types:
Screening(377)
 
 
 
Confirmatory(163)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(125)
 
 
 
 
 
IC50(28)
 
 
 
 
EC50(4)
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 505    Data Row: 550   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49679861]
Potency 2.8184qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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2
[SID49679861]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID49679861]
AC50_uM 6.597Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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4
[SID49679861]
Potency 7.3078qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID49679861]
AC50_uM 7.349ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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6
[SID49679861]
Potency 8.9125qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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7
[SID49679861]
Potency 14.1254qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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8
[SID49679861]
Potency 14.1254qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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9
[SID49679861]
Potency 15.8489qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Giardia lamblia growth inhibition [AID2785, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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10
[SID49679861]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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11
[SID49679861]
CC50 79.373Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - HeLa Cytotoxicity [AID624300, Type: confirmatory]
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12
[SID49679861]
IC50 86.05Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]rac GTPase-activating protein 1 [Homo sapiens] [gi:21361397]
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13
[SID49679861]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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14
[SID49679861]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase 2 mutant [AID1530, Type: screening]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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15
[SID49679861]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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16
[SID49679861]
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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17
[SID49679861]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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18
[SID49679861]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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19
[SID49679861]
Allosteric Agonists of the Human D1 Dopamine Receptor: qHTS [AID504660, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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20
[SID49679861]
HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]D(2) dopamine receptor isoform long [Homo sapiens] [gi:4503385]
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21
[SID49679861]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]BRCA1-associated RING domain protein 1 [gi:116241265]
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22
[SID49679861]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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23
[SID49679861]
qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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24
[SID49679861]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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25
[SID49679861]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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26
[SID49679861]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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27
[SID49679861]
Potency 10qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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28
[SID49679861]
Potency 11.2202qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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29
[SID49679861]
Potency 22.3872qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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30
[SID49679861]
Potency 35.4813qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression [AID624202, Type: confirmatory]BRCA1 [Homo sapiens] [gi:1698399]
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31
[SID49679861]
Potency 100qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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32
[SID49679861]
AC50_uM 260Luminescence Cell-Based Counter Screen to Identify Inhibitors of Cytokine Induced Apoptosis [AID463206, Type: confirmatory]
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33
[SID49679861]
Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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34
[SID49679861]
Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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35
[SID49679861]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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36
[SID49679861]
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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37
[SID49679861]
Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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38
[SID49679861]
uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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39
[SID49679861]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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40
[SID49679861]
IC50 Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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41
[SID49679861]
IC50 Primary and Confirmatory Screening for Inhibitors of Bacterial Capsule Biogenesis [AID488966, Type: confirmatory]
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42
[SID49679861]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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43
[SID49679861]
Full deck counterscreen for positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602247, Type: screening]
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44
[SID49679861]
Full deck counterscreen for agonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602248, Type: screening]
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45
[SID49679861]
Full deck counterscreen for antagonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective inhibitors and assay artifacts using the parental CHOK1 cell line [AID602250, Type: screening]
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46
[SID49679861]
uHTS luminescent assay for identification of compounds that enhance the survival of human induced pluripotent stem cells when cultured as single cells [AID602274, Type: screening]
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47
[SID49679861]
HTS for suppressors of simvastatin-induced mytoxicity in differentiated C2C12 cells Measured in Cell-Based System Using Plate Reader - 2112-01_Suppressor_SinglePoint_HTS_Activity [AID602340, Type: screening]
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48
[SID49679861]
Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_SinglePoint_HTS_Activity [AID602342, Type: screening]
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49
[SID49679861]
Whole cell Yeast HTS to identify compounds modulating the fidelity of the start codon recognition in eukaryotes. Measured in Whole Organism System Using Plate Reader - 2155-01_Other_SinglePoint_HTS_Activity [AID602363, Type: screening]
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50
[SID49679861]
uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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