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4-amino-1,8-naphthalimide (CID 1720) - Compound BioActivity Data
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BioActivity Outcomes:
Active(32)
 
 
Inactive(227)
 
 
Inconclusive(68)
 
 
Unspecified(137)
 
 
Top Targets:
7tm 4(39)
 
 
 
 
 
p450(17)
 
 
 
 
 
parp like(8)
 
 
 
 
HELICc(7)
 
 
 
 
GH27(7)
 
 
BioAssay Types:
Confirmatory(372)
 
 
 
 
 
Screening(32)
 
 
 
Literature(25)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(231)
 
 
 
 
IC50(124)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 391    Data Row: 464   Total Pages: 24   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103355081]
IC50 0.026Inhibitory activity against human PARP1 expressed in PC12 cells [AID259509, Type: Literature]Poly [ADP-ribose] polymerase 1 [gi:130781]
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2
[SID103355081]
IC50 0.18The compound was tested for poly(ADP-ribose)-polymerase (PARP) inhibition [AID154621, Type: Literature]
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3
[SID46394321]
IC50 0.18Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, The Catalytic Fragment Of Poly(Adp-Ribose) Polymerase Complexed With 4-Amino-1,8-Naphthalimide [gi:157835644]
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4
[SID46394321]
IC50 0.18Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, The Catalytic Fragment Of Poly(Adp-Ribose) Polymerase Complexed With 4-Amino-1,8-Naphthalimide [gi:157835644]
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5
[SID103355081]
IC50 0.18In vitro cytotoxicity against human lung carcinoma A549 cells [AID247676, Type: Literature]
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6
[SID103355081]
IC50 0.7Inhibition of NDM-1 (unknown origin) using nitrocefin as substrate preincubated 10 mins followed by substrate addition measured after 20 mins [AID749000, Type: Literature]
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7
[SID11110714]
Potency 0.7943qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Green Fluorophore) [AID879, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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8
[SID11110714]
Potency 0.7943qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Green Fluorophore) [AID879, Type: confirmatory]guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 [Homo sapiens] [gi:33946324]
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9
[SID90340784]
Potency 4.2562qHTS screen for enhancers of Arylsulfatase A (ASA1): LOPAC Validation Assay [AID720538, Type: confirmatory]arylsulfatase A [Homo sapiens] [gi:220983390]
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10
[SID50105795]
Potency 5.0119qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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11
[SID50105795]
Potency 5.0119qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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12
[SID103355081]
IC50 5.2Inhibition of TEM-1 (unknown origin) using nitrocefin as substrate preincubated 10 mins followed by substrate addition measured after 20 mins [AID748998, Type: Literature]
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13
[SID103355081]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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14
[SID90340784]
Potency 11.2202HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Agonists [AID488981, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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15
[SID11110714]
Potency 12.5893qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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16
[SID26753511]
Potency 17.7828Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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17
[SID50105795]
Potency 25.1189qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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18
[SID90340784]
Potency 25.1189Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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19
[SID11110714]
Potency 31.6228qHTS Assay for Modulators of Hemoglobin Beta Chain Splicing [AID925, Type: confirmatory]hemoglobin subunit beta [Homo sapiens] [gi:4504349]
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20
[SID26753511]
Potency 50.1187qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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