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2-(allylamino)-3-chloronaphthoquinone (CID 1716436) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(88)
 
 
Inactive(652)
 
 
Inconclusive(30)
 
 
Unspecified(11)
 
 
Top Targets:
7TM GPCR Srx(24)
 
 
 
7TM GPCR Srsx(20)
 
 
 
 
DUF3371(20)
 
 
 
Peptidase C48(11)
 
 
 
Bcl-2 like(11)
 
 
BioAssay Types:
Screening(485)
 
 
 
 
 
Confirmatory(267)
 
 
 
 
 
Literature(15)
 
 
 
BioActivity Types:
Potency(150)
 
 
 
 
 
AC50(48)
 
 
 
IC50(46)
 
 
 
 
EC50(10)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 713    Data Row: 781   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134418986]
AbsAC40_uM 0.276qPCR Assay for MITF Expression Measured in Cell-Based System Using RT-PCR - 2084-05_Inhibitor_Dose_DryPowder_Activity [AID651773, Type: confirmatory]microphthalmia-associated transcription factor [Homo sapiens] [gi:7684294]
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2
[SID134418986]
AC50_uM 0.735MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set7 [AID624426, Type: confirmatory]
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3
[SID134418986]
AbsAC40_uM 0.764qPCR Assay for MLANA Expression Measured in Cell-Based System Using RT-PCR - 2084-13_Inhibitor_Dose_DryPowder_Activity [AID651795, Type: confirmatory]microphthalmia-associated transcription factor [Homo sapiens] [gi:7684294]
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4
[SID134418986]
AC50_uM 0.799MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set5 [AID624363, Type: confirmatory]
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5
[SID121269797]
AC50_uM 0.905MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity [AID540348, Type: confirmatory]
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6
[SID134418986]
AbsAC40_uM 0.943qPCR Assay for TRPM1 Expression Measured in Cell-Based System Using RT-PCR - 2084-09_Inhibitor_Dose_DryPowder_Activity [AID651770, Type: confirmatory]microphthalmia-associated transcription factor [Homo sapiens] [gi:7684294]
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7
[SID134418986]
AbsAC40_uM 1qPCR Assay for DCT Expression Measured in Cell-Based System Using RT-PCR - 2084-12_Inhibitor_Dose_DryPowder_Activity [AID651771, Type: confirmatory]microphthalmia-associated transcription factor [Homo sapiens] [gi:7684294]
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8
[SID134418986]
AbsAC40_uM 1.46qPCR Assay for CDK2 Expression Measured in Cell-Based System Using RT-PCR - 2084-11_Inhibitor_Dose_DryPowder_Activity [AID651772, Type: confirmatory]microphthalmia-associated transcription factor [Homo sapiens] [gi:7684294]
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9
[SID134418986]
AC50_uM 1.56MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set6 [AID624440, Type: confirmatory]
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10
[SID134418986]
AC50_uM 1.67MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set4 [AID624316, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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11
[SID134418986]
AC50_uM 1.7MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set5 [AID624427, Type: confirmatory]
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12
[SID134970398]
AC50_uM 1.88MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set5 [AID624363, Type: confirmatory]
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13
[SID134970398]
AC50_uM 1.94MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624290, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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14
[SID134970398]
AC50_uM 2.18MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set4 [AID624316, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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15
[SID134418986]
AC50_uM 2.22MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624290, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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16
[SID22416871]
Potency 2.9362Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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17
[SID22416871]
IC50_Mean 3.62Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488901, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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18
[SID134418986]
AC50_uM 3.82MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set6 [AID624429, Type: confirmatory]
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19
[SID22416871]
AC50_uM 4.061MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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20
[SID22416871]
AC50_uM 4.061MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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21
[SID22416871]
AC50_uM 4.061MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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22
[SID134418986]
AC50_uM 4.57MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set3 [AID624259, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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23
[SID134418986]
AC50_uM 4.58MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set8 [AID651586, Type: confirmatory]
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24
[SID134970398]
AC50_uM 4.74MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set3 [AID624259, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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25
[SID22416871]
AC50_uM 4.751Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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26
[SID134418986]
AC50_uM 5.18MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624289, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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27
[SID134418986]
AC50_uM 5.58MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set9 [AID651588, Type: confirmatory]
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28
[SID134970398]
AC50_uM 7.1MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624289, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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29
[SID22416871]
AC50_uM 7.643Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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30
[SID22416871]
AC50_uM 7.675MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_CherryPick_Activity_Set3 [AID493240, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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31
[SID121269797]
AC50_uM 8.93MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_DryPowder_Activity [AID540339, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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32
[SID22416871]
IC50_Mean 9.07Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay [AID488921, Type: confirmatory]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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33
[SID134418986]
AC50_uM 9.65MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624299, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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34
[SID134418986]
AC50_uM 9.72MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set3 [AID624315, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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35
[SID134418986]
AC50_uM 9.99MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_DryPowder_Activity_Set5 [AID651584, Type: confirmatory]
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36
[SID134418986]
AC50_uM 9.99MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_DryPowder_Activity_Set6 [AID651585, Type: confirmatory]
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37
[SID22416871]
IC50_Mean 10.1Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay [AID488903, Type: confirmatory]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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38
[SID22416871]
EC50_uM 10.4Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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39
[SID134970398]
AC50_uM 12.09MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set3 [AID624315, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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40
[SID134970398]
AC50_uM 12.39MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624299, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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41
[SID22416871]
Potency 12.5893qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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42
[SID22416871]
Potency 12.5893qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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43
[SID22416871]
Potency 12.5893qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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44
[SID121269797]
AC50_uM 14.35MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity [AID540347, Type: confirmatory]
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45
[SID22416871]
Potency 14.581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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46
[SID134418986]
AC50_uM 15.42MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set4 [AID624366, Type: confirmatory]
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47
[SID22416871]
AC50_uM 15.595MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_CherryPick_Activity [AID493191, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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48
[SID22416871]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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49
[SID22416871]
Potency 16.3601Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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50
[SID22416871]
Potency 17.7828qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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