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varenicline (CID 170361) - Compound BioActivity Data
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BioActivity Outcomes:
Active(69)
 
 
Inactive(15)
 
 
Inconclusive(11)
 
 
Unspecified(88)
 
 
Top Targets:
Neur chan LBD(117)
 
 
 
 
 
KAZAL SLC21(3)
 
 
Glutaminase(1)
 
 
MFS(1)
 
 
HpcH HpaI(1)
 
 
BioAssay Types:
Literature(174)
 
 
 
 
 
Confirmatory(9)
 
 
BioActivity Types:
Ki(45)
 
 
EC50(23)
 
 
 
IC50(18)
 
 
 
 
Potency(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 122    Data Row: 183   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103471545]
Ki 5e-05Displacement of [3H]epibatidine from rat alpha4beta2 nACHR [AID700118, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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2
[SID103471545]
Ki 5e-05Displacement of [3H]epibatidine from rat alpha4beta2 nACHR [AID700118, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
3
[SID103471545]
EC50 6e-05Partial agonist activity at alpha4beta 2 nAChR [AID675881, Type: Literature]
View
4
[SID103471545]
Ki 6e-05Binding affinity to alpha4beta2 nAChR in rat cortex [AID726239, Type: Literature]
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5
[SID103471545]
Ki 6e-05Binding affinity to rat cortex Nicotinic acetylcholine receptor alpha4-beta2 using [3H]nicotine [AID254424, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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6
[SID103471545]
Ki 6e-05Binding affinity to rat cortex Nicotinic acetylcholine receptor alpha4-beta2 using [3H]nicotine [AID254424, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
7
[SID103471545]
Ki 0.00011Binding affinity for human Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK 293 cells using [3H]nicotine [AID254476, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:113105]
View
8
[SID103471545]
Ki 0.00011Binding affinity for human Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK 293 cells using [3H]nicotine [AID254476, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:1351848]
View
9
[SID103471545]
Ki 0.00012Displacement of [3H]epibatidine from rat cerebral cortex alpha4beta2* nAChR incubated for 4 hrs by liquid scintillation assay [AID699417, Type: Literature]
View
10
[SID103471545]
Ki 0.00012Displacement of [3H]epibatidine from alpha-4-beta-2 nAChR in rat cerebral cortex [AID322331, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
11
[SID103471545]
Ki 0.00012Displacement of [3H]epibatidine from alpha-4-beta-2 nAChR in rat cerebral cortex [AID322331, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
12
[SID103471545]
Ki 0.00012Displacement of [3H]-Epibatidine from rat alpha4beta2 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis [AID729084, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
13
[SID103471545]
Ki 0.00012Displacement of [3H]-Epibatidine from rat alpha4beta2 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis [AID729084, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
14
[SID103471545]
Ki 0.000295Displacement of [3H]epibatidine from alpha4beta2 nicotinic receptor expressed in human HEK293 cells [AID495031, Type: Literature]
View
15
[SID103471545]
Ki 0.0004Binding affinity to alpha4beta2 nAChR [AID710166, Type: Literature]
View
16
[SID103471545]
Ki 0.00048Displacement of [3H]-Epibatidine from rat alpha2beta2 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis [AID729088, Type: Literature]Neuronal acetylcholine receptor subunit alpha-2 [gi:2851491]
View
17
[SID103471545]
Ki 0.00048Displacement of [3H]-Epibatidine from rat alpha2beta2 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis [AID729088, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
18
[SID103471545]
Ki 0.0025Displacement of [3H]-Epibatidine from rat alpha3beta2 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis [AID729086, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
19
[SID103471545]
Ki 0.0025Displacement of [3H]-Epibatidine from rat alpha3beta2 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis [AID729086, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
View
20
[SID103471545]
Ki 0.028Displacement of [3H]-Epibatidine from rat alpha4beta4 nACHR expressed in HEK293 cell membranes by liquid scintillation counting analysis [AID729083, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View