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verlukast (CID 16760569) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(22)
 
 
Inactive(27)
 
 
Inconclusive(23)
 
 
Unspecified(4)
 
 
Top Targets:
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
 
7tm 4(4)
 
 
 
NR LBD GR(4)
 
 
 
 
NR LBD TR(3)
 
 
 
BioAssay Types:
Confirmatory(51)
 
 
 
 
Summary(15)
 
 
 
 
Literature(6)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(62)
 
 
 
 
IC50(5)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 76    Data Row: 76   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103297943]
Ki 0.0002Binding affinity against Cysteinyl leukotriene D4 receptor [AID55237, Type: Literature]
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2
[SID103297943]
IC50 0.0015Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes [AID102665, Type: confirmatory]Cysteinyl leukotriene receptor 1 [gi:123779610]
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3
[SID103297943]
IC50 0.0025Concentration required for inhibition of binding of [3H]-LTD4 to guinea pig lung membranes (different expt) [AID102666, Type: confirmatory]Cysteinyl leukotriene receptor 1 [gi:123779610]
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4
[SID144205613]
Potency-Replicate_1 1.8834qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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5
[SID144205613]
Potency-Replicate_1 2.371qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID144205613]
Potency-Replicate_1 4.7308qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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7
[SID144205613]
ATAD5 Potency (uM) 6.30862qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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8
[SID144205613]
AhR Potency (uM) 7.07838qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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9
[SID144205613]
Potency-Replicate_1 7.5624qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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10
[SID103297943]
IC50 7.57Inhibition of human MRP1 in human 2008 cells [AID365463, Type: Literature]Multidrug resistance-associated protein 1 [gi:296439301]
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11
[SID144205613]
Potency-Replicate_1 8.4852qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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12
[SID144205613]
Potency 16.7889qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID144205613]
Ratio Potency (uM) 18.9959qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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14
[SID103297943]
IC50 20.7Inhibition of human MRP2 expressed in dog MDCK2 cells [AID365464, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:308153583]
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15
[SID144205613]
Potency-Replicate_1 23.7101qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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16
[SID144205613]
Potency-Replicate_1 24.791qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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17
[SID144205613]
Ratio Potency (uM) 24.85qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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18
[SID144205613]
Potency-Replicate_1 26.6032qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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19
[SID144205613]
Potency-Replicate_1 26.6032qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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20
[SID144205613]
Potency-Replicate_1 29.8493qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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