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enprofylline (CID 1676) - Compound BioActivity Data
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BioActivity Outcomes:
Active(22)
 
 
Inactive(1215)
 
 
Inconclusive(24)
 
 
Unspecified(36)
 
 
Top Targets:
7tm 4(73)
 
 
 
 
alkPPc(14)
 
 
Tryp SPc(14)
 
 
Bcl-2 like(12)
 
 
NR LBD ER(11)
 
 
BioAssay Types:
Screening(590)
 
 
 
Confirmatory(526)
 
 
 
 
Literature(131)
 
 
 
 
Summary(16)
 
 
BioActivity Types:
Potency(441)
 
 
 
 
IC50(45)
 
 
Ki(28)
 
 
 
EC50(13)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1014    Data Row: 1297   Total Pages: 65   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103188003]
Ki 4.73Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand [AID33176, Type: Literature]
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2
[SID103188003]
Ki 4.73Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells [AID266271, Type: Literature]Adenosine receptor A2b [gi:112938]
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3
[SID103188003]
Ki 6.4Binding affinity to human adenosine A2B receptor [AID372139, Type: Literature]Adenosine receptor A2b [gi:112938]
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4
[SID103188003]
EC50 7.2Effective concentration required in vitro for tracheal muscle (from male Hartley guinea pigs) relaxation [AID73739, Type: Literature]
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5
[SID103188003]
EC50 7.2Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains. [AID74022, Type: Literature]
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6
[SID103188003]
Ki 32Binding affinity to human adenosine A2A receptor [AID372138, Type: Literature]Adenosine receptor A2a [gi:543740]
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7
[SID103188003]
Ki 32Binding affinity at Adenosine A1 receptor in rat brain cortical membrane using [3H]N6-R-phenylisopropyladenosine (R-PIA) as radioligand [AID31881, Type: Literature]
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8
[SID103188003]
Ki 32Binding affinity to rat adenosine A2A receptor [AID372142, Type: Literature]Adenosine receptor A2a [gi:8928539]
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9
[SID103188003]
Ki 42Displacement of [3H]CPX from human adenosine A3 receptor expressed in CHO cells [AID266272, Type: Literature]Adenosine receptor A1 [gi:231473]
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10
[SID103188003]
Ki 43.1Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4B [gi:729163]
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11
[SID103188003]
Ki 43.1Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4D [gi:12644392]
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12
[SID103188003]
Ki 43.1Inhibition of cyclic AMP-phosphodiesterase ( PDE) in the supernatant of tracheal muscle homogenate [AID220054, Type: Literature]
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13
[SID103188003]
Ki 43.1Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4C [gi:20141263]
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14
[SID103188003]
Ki 43.1Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscle [AID219846, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4A [gi:116242706]
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15
[SID103188003]
Ki 44Binding affinity to human adenosine A1 receptor [AID372137, Type: Literature]Adenosine receptor A1 [gi:231473]
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16
[SID103188003]
Effective concentration required in vitro for heart stimulation (right atrium) in guinea pig [AID75916, Type: Literature]
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17
[SID103188003]
Positive chronotropic effect on isolated guinea pig right atrium (heart stimulation). [AID75917, Type: Literature]Adenosine receptor A1 [gi:1351830]
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18
[SID103188003]
Inhibition against Adenosine A1 receptor of rat fat cell membranes [AID31695, Type: Literature]Adenosine receptor A1 [gi:2827766]
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19
[SID855784]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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20
[SID85209069]
Ligands of nucleotide-like (Class A) GPCRs [AID2061, Type: other]
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