NCGC00096021-01 (CID 16758186) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Inactive(50)
 
 
Inconclusive(8)
 
 
Top Targets:
p450(2)
 
 
globin(2)
 
 
BRCT(2)
 
 
CASc(2)
 
 
Tubulin-bindi..(2)
 
 
BioAssay Types:
Confirmatory(60)
 
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(58)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 61    Data Row: 61   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26750038]
Potency 3.1623qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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2
[SID26750038]
Potency 5.0119qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Region [AID923, Type: confirmatory]
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3
[SID26750038]
Potency 12.5893qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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4
[SID26750038]
Potency 12.5893qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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5
[SID26750038]
Potency 31.6228qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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6
[SID26750038]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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7
[SID26750038]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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8
[SID26750038]
Potency Confirmation and Secondary Assay for Modulators of Hemoglobin Beta Chain Splicing at IVS2 705 locus [AID930, Type: confirmatory]hemoglobin subunit beta [Homo sapiens] [gi:4504349]
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9
[SID26750038]
Potency Confirmation and Secondary Assay for Modulators of Hemoglobin Beta Chain Splicing at IVS2 654 locus [AID910, Type: confirmatory]hemoglobin subunit beta [Homo sapiens] [gi:4504349]
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10
[SID26750038]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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11
[SID26750038]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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12
[SID26750038]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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13
[SID26750038]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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14
[SID26750038]
Potency qHTS Assay for Lipid Storage Modulators [AID1519, Type: confirmatory]
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15
[SID26750038]
Potency qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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16
[SID26750038]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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17
[SID26750038]
Potency Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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18
[SID26750038]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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19
[SID26750038]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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20
[SID26750038]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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21
[SID26750038]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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22
[SID26750038]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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23
[SID26750038]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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24
[SID26750038]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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25
[SID26750038]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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26
[SID26750038]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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27
[SID26750038]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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28
[SID26750038]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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29
[SID26750038]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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30
[SID26750038]
Potency qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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31
[SID26750038]
Potency qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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32
[SID26750038]
Potency qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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33
[SID26750038]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
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34
[SID26750038]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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35
[SID26750038]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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36
[SID26750038]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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37
[SID26750038]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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38
[SID26750038]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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39
[SID26750038]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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40
[SID26750038]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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41
[SID26750038]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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42
[SID26750038]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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43
[SID26750038]
 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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44
[SID26750038]
 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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45
[SID26750038]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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46
[SID26750038]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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47
[SID26750038]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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48
[SID26750038]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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49
[SID26750038]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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50
[SID26750038]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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