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NCGC00095101-01 (CID 16757839) - Compound BioActivity Data
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BioActivity Outcomes:
Active(109)
 
 
Inactive(22)
 
 
Inconclusive(25)
 
 
Unspecified(1)
 
 
Top Targets:
HELICc(3)
 
 
Bromo ALL-1(3)
 
 
 
Runt(3)
 
 
CBF beta(3)
 
 
HSD10-like SD..(2)
 
 
BioAssay Types:
Confirmatory(94)
 
 
 
 
Literature(62)
 
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(91)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 88    Data Row: 157   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26748902]
Potency 0.0032Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2572, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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2
[SID26748902]
Potency 0.006qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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3
[SID26748902]
Potency 0.0291qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding: Initial hit validation in AlphaScreen assay for MBNL1-(CUG)12 binding [AID493205, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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4
[SID26748902]
Potency 0.0316qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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5
[SID26748902]
Potency 0.0708qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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6
[SID26748902]
Potency 0.2818qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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7
[SID26748902]
Potency 0.3162qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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8
[SID26748902]
Potency 0.3162qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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9
[SID26748902]
Potency 0.3534qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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10
[SID26748903]
Potency 0.3534qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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11
[SID26748902]
Potency 0.3854qHTS Fluorescence Polarization (FP) Assay for Inhibitors of MLL CXXC domain - DNA interaction: HTRF Assay [AID624162, Type: confirmatory]
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12
[SID26748902]
Potency 0.3981qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]core-binding factor subunit beta isoform 2 [Homo sapiens] [gi:13124873]
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13
[SID26748902]
Potency 0.3981qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]runt-related transcription factor 1 isoform AML1b [Homo sapiens] [gi:49574546]
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14
[SID26748902]
Potency 0.4105qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding: Initial hit validation from the primary screen [AID493199, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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15
[SID26748902]
Potency 0.5012qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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16
[SID26748902]
Potency 0.5012Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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17
[SID26748902]
Potency 0.5623qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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18
[SID26748902]
Potency 1qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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19
[SID26748902]
Potency 1.122Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2708, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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20
[SID26748902]
Potency 1.2589qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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21
[SID26748902]
Potency 1.5849qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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22
[SID26748902]
Potency 3.0131Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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23
[SID26748902]
Potency 3.1623qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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24
[SID26748902]
Potency 3.3808Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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25
[SID26748902]
Potency 3.5397qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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26
[SID26748902]
Potency 3.5481qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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27
[SID26748902]
Potency 3.562qHTS Fluorescence Polarization (FP) Assay for Inhibitors of MLL CXXC domain - DNA interaction: Fluorescein FP [AID624160, Type: confirmatory]
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28
[SID26748902]
Potency 3.9811Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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29
[SID26748902]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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30
[SID26748902]
Potency 4.4843qHTS Fluorescence Polarization (FP) Assay for Inhibitors of MLL CXXC domain - DNA interaction: Texas Red FP [AID624161, Type: confirmatory]
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31
[SID26748902]
Potency 5.0119Counterscreen for APE1 Inhibitors: qHTS Assay for Inhibitors of Endonuclease IV [AID2565, Type: confirmatory]endonuclease IV [Escherichia coli] [gi:405898]
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32
[SID26748902]
Potency 6.3096qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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33
[SID26748902]
Potency 7.9433qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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34
[SID26748902]
Potency 7.9433qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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35
[SID26748902]
Potency 10qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation with Orthogonal Assay [AID504375, Type: confirmatory]runt-related transcription factor 1 isoform AML1b [Homo sapiens] [gi:49574546]
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36
[SID26748902]
Potency 10qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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37
[SID26748902]
Potency 10qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation with Orthogonal Assay [AID504375, Type: confirmatory]core-binding factor subunit beta isoform 2 [Homo sapiens] [gi:13124873]
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38
[SID26748902]
Potency 11.1749qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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39
[SID26748902]
Potency 11.2202qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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40
[SID26748902]
Potency 12.5893Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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41
[SID26748902]
Potency 12.5893qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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42
[SID26748902]
Potency 12.8178Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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43
[SID26748902]
Potency 15.8489qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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44
[SID26748902]
Potency 15.8489Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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45
[SID26748902]
Potency 20.3148S16 Schwann cell viability assay (CellTiter-Glo assay) [AID624031, Type: confirmatory]
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46
[SID26748902]
Potency 22.3703S16 Schwann cell PMP22 intronic element beta-lactamase assay [AID624044, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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47
[SID26748902]
Potency 22.3872qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: ME-1 cellular proliferation [AID504370, Type: confirmatory]core-binding factor subunit beta isoform 2 [Homo sapiens] [gi:13124873]
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48
[SID26748902]
Potency 22.3872qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: ME-1 cellular proliferation [AID504370, Type: confirmatory]runt-related transcription factor 1 isoform AML1b [Homo sapiens] [gi:49574546]
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49
[SID26748902]
Potency 63.0957qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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50
[SID26748902]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_59, Type: Literature]
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