MLS000879490 (CID 16746465) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(13)
 
 
Inactive(506)
 
 
Inconclusive(27)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(6)
 
 
Tryp SPc(6)
 
 
G-alpha(5)
 
 
 
Pyr redox dim(5)
 
 
BioAssay Types:
Screening(347)
 
 
 
 
Confirmatory(189)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(146)
 
 
 
 
 
IC50(32)
 
 
 
EC50(6)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 510    Data Row: 548   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26732317]
Potency 3.6964Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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2
[SID26732317]
Potency 5.2213Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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3
[SID26732317]
EC50 6.56727Image-based HTS for Selective Agonists of GPR55 [AID1961, Type: confirmatory]G-protein coupled receptor 55 [Homo sapiens] [gi:33695107]
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4
[SID50111888]
Potency 17.7828qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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5
[SID26732317]
Potency 39.8107qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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6
[SID26732317]
Potency 39.8107qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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7
[SID26732317]
Potency 44.6684qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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8
[SID26732317]
Potency 44.6684qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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9
[SID26732317]
Potency 50.1187qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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10
[SID50111888]
Potency 56.2341qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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11
[SID26732317]
 High Throughput Screening for Cocaine Antagonists: Retest of Primary Hits [AID504858, Type: screening]dopamine transporter [Homo sapiens] [gi:7108463]
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12
[SID26732317]
 High Throughput Screening for Cocaine Antagonists: Retest of Primary Hits [AID504858, Type: screening]dopamine transporter [Homo sapiens] [gi:7108463]
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13
[SID26732317]
 High Throughput Screening for Cocaine Antagonists: Retest of Primary Hits [AID504858, Type: screening]dopamine transporter [Homo sapiens] [gi:7108463]
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14
[SID26732317]
 High Throughput Screening for Cocaine Antagonists: Retest of Primary Hits [AID504858, Type: screening]dopamine transporter [Homo sapiens] [gi:7108463]
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15
[SID26732317]
 High Throughput Screening for Cocaine Antagonists: Primary Screen [AID449768, Type: screening]dopamine transporter [Homo sapiens] [gi:7108463]
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16
[SID26732317]
 High Throughput Screening for Cocaine Antagonists: Primary Screen [AID449768, Type: screening]dopamine transporter [Homo sapiens] [gi:7108463]
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17
[SID26732317]
 High Throughput Screening for Cocaine Antagonists: Primary Screen [AID449768, Type: screening]dopamine transporter [Homo sapiens] [gi:7108463]
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18
[SID26732317]
 High Throughput Screening for Cocaine Antagonists: Primary Screen [AID449768, Type: screening]dopamine transporter [Homo sapiens] [gi:7108463]
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19
[SID26732317]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) [AID2014, Type: confirmatory]polyadenylate-binding protein 1 [Homo sapiens] [gi:46367787]
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20
[SID26732317]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) [AID2012, Type: confirmatory]Eukaryotic translation initiation factor 4H [Homo sapiens] [gi:45219878]
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21
[SID26732317]
 uHTS identification of APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493011, Type: screening]APOBEC3A gene product [Homo sapiens] [gi:21955158]
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22
[SID26732317]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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23
[SID26732317]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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24
[SID50111888]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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25
[SID50111888]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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26
[SID26732317]
Potency 15.8489qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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27
[SID26732317]
Potency qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID485294, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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28
[SID26732317]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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29
[SID50111888]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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30
[SID26732317]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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31
[SID26732317]
 uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 [gi:160877737]
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32
[SID26732317]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. [AID1415, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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33
[SID26732317]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. [AID1415, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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34
[SID26732317]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. [AID1415, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
View
35
[SID26732317]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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36
[SID26732317]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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37
[SID26732317]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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38
[SID26732317]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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39
[SID26732317]
 High Throughput Screening for Cocaine Antagonists:Counterscreen of Primary Hits [AID588389, Type: other]dopamine transporter [Homo sapiens] [gi:7108463]
View
40
[SID26732317]
 High Throughput Screening for Cocaine Antagonists:Counterscreen of Primary Hits [AID588389, Type: other]dopamine transporter [Homo sapiens] [gi:7108463]
View
41
[SID26732317]
 High Throughput Screening for Cocaine Antagonists:Counterscreen of Primary Hits [AID588389, Type: other]dopamine transporter [Homo sapiens] [gi:7108463]
View
42
[SID26732317]
 High Throughput Screening for Cocaine Antagonists:Counterscreen of Primary Hits [AID588389, Type: other]dopamine transporter [Homo sapiens] [gi:7108463]
View
43
[SID26732317]
 qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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44
[SID26732317]
 S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_SinglePoint_HTS_Activity [AID652163, Type: screening]S100A4 [Homo sapiens] [gi:47496637]
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45
[SID26732317]
Potency qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase [AID1631, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
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46
[SID26732317]
Potency qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase [AID1631, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
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47
[SID26732317]
Potency qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase [AID1631, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
View
48
[SID26732317]
Potency qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
View
49
[SID26732317]
Potency qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
View
50
[SID26732317]
Potency qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
View