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MLS000911607 (CID 16745791) - Compound BioActivity Data
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BioActivity Outcomes:
Active(26)
 
 
Inactive(558)
 
 
Inconclusive(22)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
G-alpha(8)
 
 
 
Tryp SPc(7)
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(403)
 
 
 
 
Confirmatory(192)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(134)
 
 
 
 
 
IC50(44)
 
 
 
 
 
EC50(6)
 
 
AC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 549    Data Row: 611   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49828085]
AC50_uM 0.435DiI Quencher Assay Measured in Biochemical System Using Plate Reader - 2085-08_Inhibitor_Dose_CherryPick_Activity [AID540326, Type: confirmatory]scavenger receptor class B member 1 isoform 1 [Mus musculus] [gi:14389423]
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2
[SID26725570]
IC50 0.954High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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3
[SID26725570]
Potency 5.0119Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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4
[SID49828085]
IC50_TAG_Mean 6.44Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630, Type: confirmatory]
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5
[SID49828085]
IC50_TAG_Mean 6.44Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_1, Type: confirmatory]
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6
[SID49828085]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID26725570]
Potency 8.2753Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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8
[SID49828085]
Potency 9.2qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID26725570]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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10
[SID26725570]
Potency 10.3183qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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11
[SID49828085]
Potency 19.9526qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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12
[SID49828085]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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13
[SID49828085]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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14
[SID49828085]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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15
[SID49828085]
Single concentration confirmation of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651629, Type: screening]
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16
[SID49828085]
HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_SinglePoint_HTS_Activity [AID488896, Type: screening]scavenger receptor class B member 1 isoform 1 [Mus musculus] [gi:14389423]
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17
[SID26725570]
MLPCN Streptokinase Expression Inhibition [AID1662, Type: screening]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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18
[SID26725570]
IC50 HCS for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 Cells [AID1628, Type: confirmatory]
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19
[SID26725570]
Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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20
[SID113234704]
Late stage assay provider results from the probe development effort to identify inhibitors of Fam108b: gel-based activity-based protein profiling (ABPP) assay to assess HTS hit compound inhibition and selectivity against a recombinant soluble form of Fam108b in a complex proteome [AID588651, Type: other]
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21
[SID49828085]
uHTS identification of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651582, Type: screening]
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22
[SID49828085]
Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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23
[SID113234704]
Late stage assay provider results from the probe development effort to identify inhibitors of Fam108b: gel-based activity-based protein profiling (ABPP) assay to assess HTS hit compound inhibition and selectivity against a recombinant soluble form of Fam108b [AID588649, Type: other]Fam108b protein [Mus musculus] [gi:21595511]
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24
[SID113234704]
Late stage assay provider results from the probe development effort to identify inhibitors of Fam108b: gel-based activity-based protein profiling (ABPP) assay to assess HTS hit compound inhibition and selectivity against a recombinant soluble form of Fam108b in a complex proteome [AID588651_1, Type: other]Fam108b protein [Mus musculus] [gi:21595511]
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25
[SID49828085]
Fluorescence polarization-based confirmation biochemical high throughput screening assay for inhibitors of the serine hydrolase family member Fam108b. [AID1978, Type: screening]Fam108b protein [Mus musculus] [gi:21595511]
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26
[SID49828085]
Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the serine hydrolase family member Fam108B. [AID1947, Type: screening]Fam108b protein [Mus musculus] [gi:21595511]
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27
[SID49828085]
IC50_1_TAG 5.938Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_2, Type: confirmatory]
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28
[SID49828085]
IC50_2_TAG 6.942Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_3, Type: confirmatory]
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29
[SID49828085]
IC50_1_TAG_DAPI 25Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_5, Type: confirmatory]
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30
[SID49828085]
IC50_2_TAG_DAPI 25Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_6, Type: confirmatory]
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31
[SID49828085]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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32
[SID49828085]
Potency 15.8489qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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33
[SID49828085]
IC50_TAG_DAPI_Mean 25Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_4, Type: confirmatory]
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34
[SID26725570]
Potency 35.4813qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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35
[SID49828085]
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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36
[SID26725570]
HTS to identify inhibitors of TNF-alpha Induced Cell Death in Jurkat FADD-/- Cells. [AID463075, Type: screening]
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37
[SID26725570]
384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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38
[SID49828085]
Potency Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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39
[SID26725570]
Factor XIa 1536 HTS [AID798, Type: screening]coagulation factor XI [Homo sapiens] [gi:180352]
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40
[SID49828085]
Small Molecules that selectively kill Giardia lamblia: qHTS [AID540267, Type: screening]
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41
[SID49828085]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_Activity [AID588334, Type: screening]
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42
[SID49828085]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
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43
[SID49828085]
HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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44
[SID49828085]
Cholera Quorum: HTS for inducers of light production in the absence ofautoinducers using BH1578 (luxS deficient, cqsA deficient) Measured in Microorganism System Using Plate Reader - 2132-01_Agonist_SinglePoint_HTS_Activity [AID588436, Type: screening]
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45
[SID49828085]
uHTS identification of small molecule modulators of myocardial damage [AID588492, Type: screening]
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46
[SID49828085]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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47
[SID49828085]
Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588692, Type: screening]
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48
[SID49828085]
IC50 A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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49
[SID49828085]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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50
[SID49828085]
Full deck counterscreen for positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602247, Type: screening]
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