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MLS000438293 (CID 16745545) - Compound BioActivity Data
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BioActivity Outcomes:
Active(30)
 
 
Inactive(400)
 
 
Inconclusive(33)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srsx(10)
 
 
7TM GPCR Srx(10)
 
 
G-alpha(9)
 
 
 
Bcl-2 like(7)
 
 
 
Tryp SPc(6)
 
 
BioAssay Types:
Confirmatory(236)
 
 
 
 
 
Screening(217)
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(181)
 
 
 
 
 
IC50(32)
 
 
 
EC50(14)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 403    Data Row: 464   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26725322]
Potency 7.9433qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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2
[SID26725322]
Potency 10qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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3
[SID26725322]
Potency 11.9173qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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4
[SID26725322]
Potency 12.5893qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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5
[SID26725322]
Potency 12.5893qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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6
[SID26725322]
Potency 14.1254qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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7
[SID26725322]
Potency 15.8489qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase [AID602233, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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8
[SID26725322]
Potency 22.3872qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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9
[SID26725322]
Potency 25.1189qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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10
[SID26725322]
Potency 31.6228qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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11
[SID26725322]
EC50 33.149Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of Mex-5 Binding to TCR-2 [AID1960, Type: confirmatory]Zinc finger protein mex-5 [gi:55976631]
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12
[SID26725322]
Potency 35.4813qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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13
[SID26725322]
Potency 44.6684qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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14
[SID26725322]
Potency 56.2341Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) - Round 2 Cherry Picks [AID504841, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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15
[SID26725322]
EC50 91.471Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of POS-1 Binding to mex-3-RNA [AID1964, Type: confirmatory]Protein POS-1 [Caenorhabditis elegans] [gi:17562800]
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16
[SID26725322]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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17
[SID26725322]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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18
[SID26725322]
uHTS fluorescent assay for identification of inhibitors of ATG4B [AID504462, Type: screening]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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19
[SID26725322]
uHTS identification of APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493011, Type: screening]DNA dC->dU-editing enzyme APOBEC-3A isoform a [Homo sapiens] [gi:21955158]
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20
[SID26725322]
Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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21
[SID26725322]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ RPL19A_MLPCN. [AID2025, Type: screening]RPL19A [Saccharomyces cerevisiae] [gi:536029]
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22
[SID26725322]
Single concentration counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay [AID588402, Type: other]phospholipase A2 precursor [Homo sapiens] [gi:4505847]
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23
[SID26725322]
384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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24
[SID26725322]
384-well Z-Lyte format Hck-Nef inhibitor HTS: Confirmation Assays [AID463188, Type: other]
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25
[SID26725322]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 Second Cherry Pick Compounds [AID2621, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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26
[SID26725322]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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27
[SID26725322]
Counterscreen for MCL1 inhibitors: fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2166, Type: screening]bcl-2-like protein 1 isoform 1 [Homo sapiens] [gi:20336335]
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28
[SID26725322]
uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) [AID493160, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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29
[SID26725322]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2057, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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30
[SID26725322]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2168, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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31
[SID26725322]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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32
[SID26725322]
Potency 7.9433qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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33
[SID26725322]
Potency 10qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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34
[SID26725322]
Potency 10.4179Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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35
[SID26725322]
Potency 11.6891Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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36
[SID26725322]
EC50 110Luminescence-based Microorganism Dose Response HTS to Identify Inhibitors of E. Coli Growth [AID1959, Type: confirmatory]
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37
[SID26725322]
Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 Activity [AID2099, Type: screening]
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38
[SID26725322]
Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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39
[SID26725322]
Potency qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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40
[SID26725322]
Potency qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21 [AID2289, Type: confirmatory]
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41
[SID26725322]
uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line [AID2380, Type: screening]
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42
[SID26725322]
IC50 A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) [AID2391, Type: confirmatory]
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43
[SID26725322]
IC50 A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag - Counter Screen [AID2501, Type: confirmatory]
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44
[SID26725322]
Potency qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells [AID2685, Type: confirmatory]
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45
[SID26725322]
A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide [AID2690, Type: screening]
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46
[SID26725322]
Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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47
[SID26725322]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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48
[SID26725322]
Test compound autofluorescence in Saccharomyes cerevisiae specifically s288c [AID2757, Type: other]
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49
[SID26725322]
IC90 Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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50
[SID26725322]
uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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