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MLS000438302 (CID 16745542) - Compound BioActivity Data
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BioActivity Outcomes:
Active(19)
 
 
Inactive(595)
 
 
Inconclusive(28)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
7TM GPCR Srsx(15)
 
 
G-alpha(9)
 
 
 
Tryp SPc(9)
 
 
 
HELICc(6)
 
 
 
 
BioAssay Types:
Screening(401)
 
 
 
 
Confirmatory(230)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(174)
 
 
 
 
 
IC50(39)
 
 
 
 
EC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 562    Data Row: 643   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26725319]
IC50 7.64Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay [AID602368, Type: confirmatory]PSMD14 protein [Homo sapiens] [gi:16306916]
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2
[SID26725319]
IC50 7.84Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay [AID602369, Type: confirmatory]TPA: prothrombin [Bos taurus] [gi:296479639]
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3
[SID26725319]
Potency 15.8489qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay [AID743286, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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4
[SID26725319]
Potency 39.8107qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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5
[SID26725319]
Potency 39.8107qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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6
[SID26725319]
Potency 50.1187qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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7
[SID26725319]
Potency 50.1187qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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8
[SID26725319]
Potency 70.7946qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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9
[SID26725319]
Potency 79.4328qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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10
[SID26725319]
Potency 79.4328qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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11
[SID26725319]
Potency 79.4328Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) - Round 2 Cherry Picks [AID504841, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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12
[SID26725319]
IC50 uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. [AID1986, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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13
[SID26725319]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID540248, Type: other]HTRA1 protein [gi:121945198]
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14
[SID26725319]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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15
[SID26725319]
Single concentration confirmation of uHTS inhibitor hits from RPN11 in a Fluorescence Polarization assay [AID602318, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
View
16
[SID26725319]
uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assay [AID588493, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
View
17
[SID26725319]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of GLD-1 protein - TGE RNA interaction. [AID2280, Type: screening]Protein GLD-1 [Caenorhabditis elegans] [gi:17507875]
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18
[SID26725319]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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19
[SID26725319]
uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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20
[SID26725319]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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21
[SID26725319]
Potency 0.0316qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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22
[SID26725319]
Potency 0.7943qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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23
[SID26725319]
Potency 11.2202qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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24
[SID26725319]
Potency 17.7828qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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25
[SID26725319]
Potency 18.526Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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26
[SID26725319]
Potency 22.3872qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction [AID624246, Type: confirmatory]transcriptional regulator ERG isoform 3 [Homo sapiens] [gi:343478176]
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27
[SID26725319]
EC50_Mean 100Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor [AID488865, Type: confirmatory]type-1 angiotensin II receptor isoform 1 [Homo sapiens] [gi:4501997]
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28
[SID26725319]
IC50 100Dose Response validation of uHTS RPN11 inhibitor hits using a MMP-2 Fluorescence assay [AID602361, Type: confirmatory]72 kDa type IV collagenase isoform a preproprotein [Homo sapiens] [gi:11342666]
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29
[SID26725319]
EC50_Mean 100Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay [AID488748, Type: confirmatory]apelin receptor [Homo sapiens] [gi:4885057]
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30
[SID26725319]
uHTS identification of small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay [AID2520, Type: screening]apelin receptor [Homo sapiens] [gi:4885057]
View
31
[SID26725319]
uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2521, Type: screening]apelin receptor [Homo sapiens] [gi:4885057]
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32
[SID26725319]
Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652010, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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33
[SID26725319]
Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1) [AID504766, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
View
34
[SID26725319]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4) [AID463165, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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35
[SID26725319]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) [AID463111, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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36
[SID26725319]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
37
[SID26725319]
Potency Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
38
[SID26725319]
Potency Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS [AID504842, Type: confirmatory]chaperonin-containing TCP-1 beta subunit homolog [Homo sapiens] [gi:4090929]
View
39
[SID26725319]
Potency qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
View
40
[SID26725319]
HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
View
41
[SID26725319]
Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID1974, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
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42
[SID26725319]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492956, Type: screening]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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43
[SID26725319]
Potency qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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44
[SID26725319]
uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651636, Type: screening]G-protein coupled receptor 183 [Homo sapiens] [gi:4826706]
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45
[SID26725319]
uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
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46
[SID124797219]
A screen for small molecule inhibitors of the human deubiquitinating enzyme, UCH37 [AID588478, Type: other]ubiquitin C-terminal hydrolase UCH37 [Homo sapiens] [gi:4877999]
View
47
[SID26725319]
qHTS Assay for Inhibitors of the Six1/Eya2 Interaction [AID651725, Type: screening]six1 [Homo sapiens] [gi:1246761]
View
48
[SID26725319]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ MEP2_MLPCN. [AID2016, Type: screening]MEP2 [Saccharomyces cerevisiae] [gi:1302091]
View
49
[SID26725319]
uHTS for Calpain Inhibitors [AID1236, Type: screening]calpain II, partial [Sus scrofa] [gi:1628587]
View
50
[SID26755144]
Potency Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
View