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MLS000541664 (CID 16727388) - Compound BioActivity Data
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BioActivity Outcomes:
Active(51)
 
 
Inactive(420)
 
 
Inconclusive(23)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(26)
 
 
 
CASc(12)
 
 
 
Peptidase C48(11)
 
 
 
KCNQ channel(9)
 
 
WD40(6)
 
 
 
BioAssay Types:
Screening(374)
 
 
 
 
Confirmatory(108)
 
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(71)
 
 
 
 
 
IC50(22)
 
 
 
AC50(8)
 
 
 
 
EC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 449    Data Row: 495   Total Pages: 25   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47193981]
AbsAC26_uM 0.207Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_Dose_CherryPick_Activity [AID624491, Type: confirmatory]
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2
[SID47193981]
Potency 1.2995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID47193981]
EC50_uM 1.34Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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4
[SID47193981]
IC50_Mean 1.47Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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5
[SID47193981]
IC50_Mean 1.47Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-9 isoform alpha precursor [Homo sapiens] [gi:14790124]
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6
[SID47193981]
IC50_Mean 1.55Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay [AID488921, Type: confirmatory]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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7
[SID47193981]
Potency 1.8356qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID47193981]
EC50_uM 1.853Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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9
[SID47193981]
IC50_Mean 1.88Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488901, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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10
[SID47193981]
AC50_uM 1.924Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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11
[SID47193981]
IC50_Mean 2.19Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay [AID488904, Type: confirmatory]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
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12
[SID47193981]
AC50_uM 2.44VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity [AID720632, Type: confirmatory]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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13
[SID47193981]
IC50_Mean 2.45Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay [AID488903, Type: confirmatory]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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14
[SID47193981]
IC50_Mean 2.5Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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15
[SID47193981]
Potency 5.0119Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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16
[SID47193981]
AC50_uM 5.9Caspase 7 Counterscreen for Selectivity Fluorescent Measured in Cell-Based System Using Plate Reader - 7052-04_Inhibitor_Dose_CherryPick_Activity [AID743295, Type: confirmatory]Caspase-7 [gi:1730092]
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17
[SID47193981]
AC50_uM 6.14Caspase 8 Counterscreen for Selectivity Fluorescent Measured in Biochemical System Using Plate Reader - 7052-05_Inhibitor_Dose_CherryPick_Activity [AID743294, Type: confirmatory]Caspase-8 [gi:2493531]
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18
[SID47193981]
AC50_uM 10.09Caspase 9 Counterscreen for Selectivity Fluorescent Measured in Biochemical System Using Plate Reader - 7052-06_Inhibitor_Dose_CherryPick_Activity [AID743293, Type: confirmatory]Caspase-9 [gi:28558771]
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19
[SID47193981]
Potency 16.3601A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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20
[SID47193981]
Potency 18.3564qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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