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CC-PMLSC-PW-wdp2244 (CID 16727385) - Compound BioActivity Data
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BioActivity Outcomes:
Active(47)
 
 
Inactive(444)
 
 
Inconclusive(9)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(26)
 
 
CASc(12)
 
 
 
Peptidase C48(11)
 
 
 
WD40(6)
 
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(372)
 
 
 
 
Confirmatory(116)
 
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(71)
 
 
 
 
 
IC50(23)
 
 
 
AC50(12)
 
 
 
EC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 456    Data Row: 501   Total Pages: 26   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47194040]
EC50_uM 1.99Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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2
[SID47194040]
IC50_Mean 3.14Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay [AID488921, Type: confirmatory]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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3
[SID47194040]
IC50_Mean 3.47Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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4
[SID47194040]
IC50_Mean 3.47Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-9 isoform alpha precursor [Homo sapiens] [gi:14790124]
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5
[SID47194040]
AC50_uM 3.75VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity [AID720632, Type: confirmatory]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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6
[SID47194040]
IC50_Mean 4.23Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay [AID488903, Type: confirmatory]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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7
[SID47194040]
IC50_Mean 4.42Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488901, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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8
[SID47194040]
IC50_Mean 4.7Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay [AID488904, Type: confirmatory]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
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9
[SID47194040]
IC50_Mean 6.11Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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10
[SID47194040]
AC50_uM 9.329Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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11
[SID47194040]
AC50_uM 12.2Caspase 7 Counterscreen for Selectivity Fluorescent Measured in Cell-Based System Using Plate Reader - 7052-04_Inhibitor_Dose_CherryPick_Activity [AID743295, Type: confirmatory]Caspase-7 [gi:1730092]
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12
[SID47194040]
AC50_uM 13.39Caspase 8 Counterscreen for Selectivity Fluorescent Measured in Biochemical System Using Plate Reader - 7052-05_Inhibitor_Dose_CherryPick_Activity [AID743294, Type: confirmatory]Caspase-8 [gi:2493531]
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13
[SID47194040]
Potency 14.1254Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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14
[SID47194040]
AC50_uM 15.53Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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15
[SID47194040]
EC50_uM 16.42Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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16
[SID47194040]
AC50_uM 28.8Caspase 9 Counterscreen for Selectivity Fluorescent Measured in Biochemical System Using Plate Reader - 7052-06_Inhibitor_Dose_CherryPick_Activity [AID743293, Type: confirmatory]Caspase-9 [gi:28558771]
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17
[SID47194040]
EC50_uM 135.8Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) [AID435004, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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18
[SID47194040]
EC50_uM 321.7Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. [AID435026, Type: confirmatory]karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b [Homo sapiens] [gi:119609447]
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19
[SID47194040]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 7 (SENP7) [AID434973, Type: screening]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
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20
[SID47194040]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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