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CC-PMLSC-PW-wdp2237 (CID 16727381) - Compound BioActivity Data
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BioActivity Outcomes:
Active(27)
 
 
Inactive(433)
 
 
Inconclusive(14)
 
 
Unspecified(4)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
7TM GPCR Srsx(11)
 
 
FA58C(7)
 
 
 
 
NB-ARC(6)
 
 
 
CASc(5)
 
 
 
BioAssay Types:
Screening(354)
 
 
 
 
Confirmatory(112)
 
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(71)
 
 
 
 
 
IC50(24)
 
 
 
 
EC50(8)
 
 
 
AC50(7)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 430    Data Row: 478   Total Pages: 24   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47193948]
EC50 3.996Luminescence Cell-Based Dose Confimation HTS to Identify Activators of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID2003, Type: confirmatory]
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2
[SID47193948]
IC50_Mean 5.07Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-9 isoform alpha precursor [Homo sapiens] [gi:14790124]
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3
[SID47193948]
IC50_Mean 5.07Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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4
[SID47193948]
AC50_uM 5.89VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity [AID720632, Type: confirmatory]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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5
[SID47193948]
EC50 6.149Luminescence Cell-Based Dose Response HTS to Identify Activators of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID2002, Type: confirmatory]
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6
[SID47193948]
IC50_Mean 7.38Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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7
[SID47193948]
Potency 12.5893Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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8
[SID47193948]
AC50_uM 14.03Human Ras-Converting Enzyme Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-04_Inhibitor_Dose_CherryPick_Activity [AID588849, Type: confirmatory]CAAX prenyl protease 2 isoform 2 [Homo sapiens] [gi:73858575]
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9
[SID47193948]
IC50_AlphaScreen_Mean 19.5Dose Response confirmation of small molecule modulators of the interaction between CendR and NRP-1 in a panel assay [AID651650_4, Type: confirmatory]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin-1 [gi:160877737]
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10
[SID47193948]
EC50 36.75Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1999, Type: confirmatory]
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11
[SID47193948]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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12
[SID47193948]
Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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13
[SID47193948]
Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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14
[SID47193948]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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15
[SID47193948]
Single concentration confirmation of uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID504614, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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16
[SID47193948]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6) [AID2599, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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17
[SID47193948]
uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin-1 [gi:160877737]
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18
[SID47193948]
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of RecA Intein Splicing Activity [AID2221, Type: screening]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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19
[SID47193948]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 7 (SENP7) [AID434973, Type: screening]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
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20
[SID47193948]
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of the Ras-converting Enzyme [AID2563, Type: screening]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
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