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TG101348 (CID 16722836) - Compound BioActivity Data
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BioActivity Outcomes:
Active(327)
 
 
Inactive(16)
 
 
Unspecified(119)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
STKc AGC(17)
 
 
 
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
 
BioAssay Types:
Literature(447)
 
 
 
 
Confirmatory(15)
 
 
BioActivity Types:
Kd(442)
 
 
 
Potency(16)
 
 
IC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 462    Data Row: 462   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123089189]
Kd 0.0011Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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2
[SID123089189]
Kd 0.0011Binding constant for GAK kinase domain [AID625012, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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3
[SID123089189]
Kd 0.0012Binding constant for DAPK3 kinase domain [AID624834, Type: Literature]Death-associated protein kinase 3 [gi:38604691]
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4
[SID123089189]
IC50 0.003Inhibition of human recombinant JAK2 by TR-FRET assay [AID538224, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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5
[SID123089189]
Kd 0.0049Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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6
[SID123089189]
Kd 0.0064Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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7
[SID123089189]
Kd 0.0066Binding constant for STK16 kinase domain [AID624775, Type: Literature]Serine/threonine-protein kinase 16 [gi:46577677]
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8
[SID123089189]
Kd 0.013Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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9
[SID123089189]
Kd 0.013Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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10
[SID123089189]
Kd 0.013Binding constant for DCAMKL3 kinase domain [AID624707, Type: Literature]Serine/threonine-protein kinase DCLK3 [gi:115502142]
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11
[SID123089189]
Kd 0.016Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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12
[SID123089189]
Kd 0.016Binding constant for DAPK1 kinase domain [AID624971, Type: Literature]Death-associated protein kinase 1 [gi:317373595]
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13
[SID123089189]
Kd 0.018Binding constant for JAK1(JH1domain-catalytic) kinase domain [AID624859, Type: Literature]Tyrosine-protein kinase JAK1 [gi:215274013]
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14
[SID123089189]
Kd 0.019Binding constant for YSK4 kinase domain [AID625136, Type: Literature]Mitogen-activated protein kinase kinase kinase 19 [gi:74755104]
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15
[SID123089189]
Kd 0.02Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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16
[SID123089189]
Kd 0.021Binding constant for TYK2(JH1domain-catalytic) kinase domain [AID624912, Type: Literature]Non-receptor tyrosine-protein kinase TYK2 [gi:56405328]
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17
[SID123089189]
Kd 0.029Binding constant for DAPK2 kinase domain [AID625077, Type: Literature]Death-associated protein kinase 2 [gi:38605084]
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18
[SID123089189]
Kd 0.029Binding constant for FLT3(R834Q) kinase domain [AID624940, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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19
[SID123089189]
Kd 0.032Binding constant for BIKE kinase domain [AID625109, Type: Literature]BMP-2-inducible protein kinase [gi:34222653]
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20
[SID123089189]
Kd 0.034Binding constant for ARK5 kinase domain [AID625088, Type: Literature]NUAK family SNF1-like kinase 1 [gi:14424095]
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21
[SID123089189]
Kd 0.035Binding constant for AAK1 kinase domain [AID625089, Type: Literature]AP2-associated protein kinase 1 [gi:300669613]
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22
[SID123089189]
Kd 0.038Binding constant for FYN kinase domain [AID624727, Type: Literature]Tyrosine-protein kinase Fyn [gi:125370]
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23
[SID123089189]
Kd 0.039Binding constant for SIK kinase domain [AID624733, Type: Literature]Serine/threonine-protein kinase SIK1 [gi:59803093]
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24
[SID123089189]
Kd 0.04Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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25
[SID123089189]
Kd 0.042Binding constant for FAK kinase domain [AID624729, Type: Literature]Focal adhesion kinase 1 [gi:3183518]
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26
[SID123089189]
Kd 0.044Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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27
[SID123089189]
Kd 0.045Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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28
[SID123089189]
Kd 0.045Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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29
[SID123089189]
Kd 0.045Binding constant for DRAK2 kinase domain [AID624942, Type: Literature]Serine/threonine-protein kinase 17B [gi:14423909]
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30
[SID123089189]
Kd 0.046Binding constant for KIT(A829P) kinase domain [AID624787, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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31
[SID123089189]
Kd 0.049Binding constant for SNARK kinase domain [AID625139, Type: Literature]NUAK family SNF1-like kinase 2 [gi:74761376]
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32
[SID123089189]
Kd 0.05Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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33
[SID123089189]
Kd 0.054Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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34
[SID123089189]
Kd 0.056Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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35
[SID123089189]
Kd 0.058Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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36
[SID123089189]
Kd 0.061Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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37
[SID123089189]
Kd 0.064Binding constant for TNK2 kinase domain [AID624807, Type: Literature]Activated CDC42 kinase 1 [gi:229462980]
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38
[SID123089189]
Kd 0.065Binding constant for ABL1(T315I)-phosphorylated kinase domain [AID624989, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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39
[SID123089189]
Kd 0.066Binding constant for ERK5 kinase domain [AID624888, Type: Literature]Mitogen-activated protein kinase 7 [gi:205371766]
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40
[SID123089189]
Kd 0.066Binding constant for PIP5K1A kinase domain [AID624824, Type: Literature]Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [gi:74752158]
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41
[SID123089189]
Kd 0.071Binding constant for RET(V804L) kinase domain [AID625123, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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42
[SID123089189]
Kd 0.072Binding constant for LCK kinase domain [AID625013, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
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43
[SID123089189]
Kd 0.074Binding constant for JAK3(JH1domain-catalytic) kinase domain [AID624785, Type: Literature]Tyrosine-protein kinase JAK3 [gi:50403745]
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44
[SID123089189]
Kd 0.075Binding constant for SRC kinase domain [AID625016, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
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45
[SID123089189]
Kd 0.079Binding constant for ULK2 kinase domain [AID625085, Type: Literature]Serine/threonine-protein kinase ULK2 [gi:296453001]
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46
[SID123089189]
Kd 0.081Binding constant for RET(V804M) kinase domain [AID625124, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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47
[SID123089189]
Kd 0.082Binding constant for FGR kinase domain [AID625011, Type: Literature]Tyrosine-protein kinase Fgr [gi:125358]
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48
[SID123089189]
Kd 0.091Binding constant for RIOK3 kinase domain [AID624926, Type: Literature]Serine/threonine-protein kinase RIO3 [gi:126302595]
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49
[SID123089189]
Kd 0.092Binding constant for TBK1 kinase domain [AID625072, Type: Literature]Serine/threonine-protein kinase TBK1 [gi:74761953]
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50
[SID123089189]
Kd 0.096Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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