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SPECTRUM1505308 (CID 16717692) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(33)
 
 
Inactive(73)
 
 
Inconclusive(56)
 
 
Unspecified(1)
 
 
Top Targets:
HELICc(3)
 
 
Bromo ALL-1(3)
 
 
 
globin(2)
 
 
P53(2)
 
 
HSD10-like SD..(2)
 
 
BioAssay Types:
Confirmatory(87)
 
 
 
 
Literature(64)
 
 
 
 
 
Screening(4)
 
 
BioActivity Types:
Potency(84)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 94    Data Row: 163   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26749092]
Potency 0.8913qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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2
[SID26749092]
Potency 1.122qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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3
[SID26749092]
Potency 2.5119qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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4
[SID26749092]
Potency 2.8184Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2572, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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5
[SID26749092]
Potency 2.8184Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2708, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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6
[SID26749092]
Potency 6.3096qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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7
[SID26749092]
Potency 6.3096qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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8
[SID26749092]
Potency 6.3096qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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9
[SID26749092]
Potency 7.6893qHTS Fluorescence Polarization (FP) Assay for Inhibitors of MLL CXXC domain - DNA interaction: HTRF Assay [AID624162, Type: confirmatory]
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10
[SID26749092]
Potency 7.9433qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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11
[SID26749092]
Potency 7.9433qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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12
[SID26749092]
Potency 11.2202qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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13
[SID26749092]
Potency 11.2202Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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14
[SID26749092]
Potency 14.0919qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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15
[SID26749092]
Potency 14.1254qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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16
[SID26749092]
Potency 15.8489Counterscreen for APE1 Inhibitors: qHTS Assay for Inhibitors of Endonuclease IV [AID2565, Type: confirmatory]endonuclease IV [Escherichia coli] [gi:405898]
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17
[SID26749092]
Potency 19.9526qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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18
[SID26749092]
Potency 19.9526Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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19
[SID26749092]
Potency 25.1189Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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20
[SID26749092]
Potency 25.1189qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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21
[SID26749092]
Potency 31.4952qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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22
[SID26749093]
Potency 31.4952qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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23
[SID26749094]
Potency 31.4952qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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24
[SID26749092]
Potency 31.6228Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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25
[SID26749092]
Potency 32.1968Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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26
[SID26749092]
Potency 44.6684qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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27
[SID26749092]
Potency 44.6684qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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28
[SID26749092]
Potency 44.6684Counterscreen for RECQ1 Inhibitors: ADP Fluorescence Polarization Displacement Assay [AID2711, Type: confirmatory]
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29
[SID26749092]
Potency 44.6684Counterscreen for BLMA Inhibitors: ADP Fluorescence Polarization Displacement Assay [AID2712, Type: confirmatory]
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30
[SID26749092]
Potency 44.8433qHTS Fluorescence Polarization (FP) Assay for Inhibitors of MLL CXXC domain - DNA interaction: Fluorescein FP [AID624160, Type: confirmatory]
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31
[SID26749092]
Potency 126.386qHTS Fluorescence Polarization (FP) Assay for Inhibitors of MLL CXXC domain - DNA interaction: Texas Red FP [AID624161, Type: confirmatory]
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32
[SID92124754]
A screen for compounds that modulate the activity of the Staphylococcus aureus MgrA protein [AID602314, Type: other]MarR family regulatory protein [Staphylococcus aureus subsp. aureus str. Newman] [gi:151220867]
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33
[SID26749092]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_3, Type: Literature]
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34
[SID26749092]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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35
[SID26749092]
Potency 11.2202qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase 1 [gi:44888968]
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36
[SID26749092]
Potency 39.8107qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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37
[SID26749092]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1 [AID900, Type: confirmatory]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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38
[SID92124754]
A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis [AID540299, Type: Literature]Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) [Mycobacterium tuberculosis H37Rv] [gi:15607688]
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39
[SID92307857]
A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus [AID720641, Type: other]anion-binding protein [Staphylococcus aureus subsp. aureus Mu50] [gi:15923709]
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40
[SID26749092]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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41
[SID26612888]
Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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42
[SID26612888]
Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen [AID1422, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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43
[SID26749092]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 [Homo sapiens] [gi:33946324]
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44
[SID26749092]
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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45
[SID26749092]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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46
[SID26749092]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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47
[SID26749092]
Potency S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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48
[SID26749092]
Potency S16 Schwann cell PMP22 intronic element beta-lactamase assay [AID624044, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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49
[SID92124754]
A screen for compounds that inhibit replication of Vibrio cholerae chromosome II [AID504770, Type: other]hypothetical protein VC_A0002 [Vibrio cholerae O1 biovar El Tor str. N16961] [gi:9657380]
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50
[SID26749092]
Potency qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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