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MLS000779134 (CID 16682713) - Compound BioActivity Data
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BioActivity Outcomes:
Active(71)
 
 
Inactive(539)
 
 
Inconclusive(39)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
7TM GPCR Srsx(17)
 
 
alkPPc(12)
 
 
 
G-alpha(8)
 
 
 
Tryp SPc(7)
 
 
BioAssay Types:
Screening(421)
 
 
 
 
Confirmatory(210)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(149)
 
 
 
 
 
IC50(41)
 
 
 
 
EC50(9)
 
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 592    Data Row: 650   Total Pages: 33   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26671498]
Potency 0.7943qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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2
[SID26671498]
Potency 1.5101qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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3
[SID26671498]
AC50_uM 1.9Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity [AID1053173, Type: confirmatory]histone-lysine N-methyltransferase NSD2 isoform 1 [Homo sapiens] [gi:109633019]
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4
[SID26671498]
Potency 1.9182qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds. [AID720497, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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5
[SID26671498]
IC50 2.16QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID2195, Type: confirmatory]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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6
[SID26671498]
AC50_uM 2.706MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity [AID588345, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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7
[SID26671498]
Potency 3.0402qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors [AID720503, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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8
[SID26671498]
Potency 3.1623qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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9
[SID26671498]
Potency 3.1623qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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10
[SID26671498]
Potency 3.9811qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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11
[SID26671498]
Potency 3.9811qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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12
[SID26671498]
IC50 4.57Fluorescent assay for identification of compounds that inhibit VHR1 [AID1878, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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13
[SID26671498]
Potency 4.7755qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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14
[SID26671498]
Potency 5.0119qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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15
[SID26671498]
IC50 5.26044Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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16
[SID26671498]
EC50_Mean 6.35Dose Response concentration confirmation of uHTS hits from a small molecule activators of mouse intestinal alkaline phosphatase via a luminescent assay [AID488783, Type: confirmatory]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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17
[SID26671498]
Potency 6.7016qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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18
[SID26671498]
Potency 7.0795qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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19
[SID26671498]
AbsAC35_uM 7.09ALPHAscreen artifact counterscreen Measured in Biochemical System Using Plate Reader - 7053-03_Inhibitor_Dose_CherryPick_Activity [AID1053174, Type: confirmatory]
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20
[SID26671498]
Potency 7.9433qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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