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MLS000738130 (CID 16682403) - Compound BioActivity Data
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BioActivity Outcomes:
Active(103)
 
 
Inactive(359)
 
 
Inconclusive(55)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(36)
 
 
 
G-alpha(8)
 
 
 
Tryp SPc(6)
 
 
 
CAP ED(5)
 
 
 
PIKKc ATM(5)
 
 
 
 
BioAssay Types:
Screening(275)
 
 
 
 
Confirmatory(224)
 
 
 
 
 
Literature(11)
 
 
 
BioActivity Types:
Potency(157)
 
 
 
 
 
IC50(36)
 
 
 
 
EC50(22)
 
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 464    Data Row: 518   Total Pages: 26   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26664449]
Potency 0.0329Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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2
[SID26664449]
Potency 0.037Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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3
[SID26664449]
Absolute IC50 0.39Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) [AID1275, Type: confirmatory]neutrophil cytosol factor 1 [Homo sapiens] [gi:115298672]
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4
[SID26664449]
Potency 0.4109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID26664449]
Potency 0.651qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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6
[SID26664449]
EC50 1A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhimurium identified in the primary screen [AID2253, Type: confirmatory]
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7
[SID26664449]
Potency 1.122qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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8
[SID26664449]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID26664449]
Potency 3.1623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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10
[SID26664449]
Potency 3.5481Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2708, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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11
[SID26664449]
Potency 4.1095qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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12
[SID26664449]
EC50 5.736Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast [AID1933, Type: confirmatory]
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13
[SID26664449]
Potency 6.3096qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]core-binding factor subunit beta isoform 2 [Homo sapiens] [gi:13124873]
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14
[SID26664449]
Potency 6.3096qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]runt-related transcription factor 1 isoform AML1b [Homo sapiens] [gi:49574546]
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15
[SID26664449]
Potency 7.0795Counterscreen for RECQ1 Inhibitors: ADP Fluorescence Polarization Displacement Assay [AID2711, Type: confirmatory]
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16
[SID26664449]
Potency 7.0795Counterscreen for BLMA Inhibitors: ADP Fluorescence Polarization Displacement Assay [AID2712, Type: confirmatory]
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17
[SID26664449]
EC50 7.131Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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18
[SID26664449]
EC50 7.392Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast [AID1936, Type: confirmatory]
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19
[SID26664449]
Potency 7.9433qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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20
[SID26664449]
Potency 8.1995qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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