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SureCN3028164 (CID 16661702) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(1)
 
 
Unspecified(22)
 
 
Top Targets:
NR LBD PR(2)
 
 
 
CAP ED(1)
 
 
BioAssay Types:
Literature(34)
 
 
 
 
BioActivity Types:
IC50(7)
 
 
 
EC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 34    Data Row: 34   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103692444]
EC50 0.003Agonist activity at PR expressed in african green monkey CV-1 cells by luciferase reporter assay [AID433752, Type: Literature]
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2
[SID103692444]
EC50 0.009Agonist activity at PR expressed in human T47D cells [AID433765, Type: Literature]
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3
[SID103692444]
EC50 0.009Agonist activity at PR in human T47D cells [AID455831, Type: Literature]Progesterone receptor [gi:90110048]
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4
[SID103692444]
IC50 0.016Inhibition of PR [AID455829, Type: Literature]
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5
[SID103692444]
IC50 0.016Binding affinity to PR by fluorescence polarization based competition binding assay [AID433751, Type: Literature]
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6
[SID103692444]
IC50 0.25Binding affinity to AR by fluorescence polarization based competition binding assay [AID433753, Type: Literature]
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7
[SID103692444]
IC50 0.78Inhibition of human ERG by patch clamp technique [AID455850, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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8
[SID103692444]
IC50 1.1Inhibition of CYP2C9 [AID455834, Type: Literature]
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9
[SID103692444]
IC50 1.6Inhibition of CYP2D6 [AID455833, Type: Literature]
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10
[SID103692444]
EC50 5Agonist activity at MR expressed in african green monkey CV-1 cells by luciferase reporter assay [AID433757, Type: Literature]
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11
[SID103692444]
EC50 7.9Antagonist activity at GR expressed in human A549 cell line [AID433758, Type: Literature]
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12
[SID103692444]
IC50 10Binding affinity to ERbeta by fluorescence polarization based competition binding assay [AID433754, Type: Literature]
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13
[SID103692444]
Selectivity ratio of PR to GR [AID433755, Type: Literature]
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14
[SID103692444]
Agonist activity at AR expressed in african green monkey CV-1 cells by luciferase reporter assay [AID433756, Type: Literature]
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15
[SID103692444]
Selectivity ratio IC50 for PR to IC50 for ERbeta [AID433760, Type: Literature]
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16
[SID103692444]
Selectivity ratio IC50 for PR to IC50 for AR [AID433761, Type: Literature]
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17
[SID103692444]
Selectivity ratio EC50 for PR to EC50 for AR [AID433762, Type: Literature]
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18
[SID103692444]
Selectivity ratio EC50 for PR to EC50 for MR [AID433763, Type: Literature]
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19
[SID103692444]
Selectivity ratio EC50 for PR to EC50 for GR [AID433764, Type: Literature]
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20
[SID103692444]
Agonist activity at PR expressed in human T47D cells relative to progesterone [AID433766, Type: Literature]
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21
[SID103692444]
Activity at PR expressed in rat ELT3 cells assessed as inhibition of estrogen-induced SDF-1 expression [AID433767, Type: Literature]
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22
[SID103692444]
Inhibition of estrogen-stimulated utrine wet weight gain in po dosed ovariectomized rat model [AID433768, Type: Literature]
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23
[SID103692444]
Agonist activity at PR expressed in african green monkey CV-1 cells by luciferase reporter assay relative to progesterone [AID433770, Type: Literature]
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24
[SID103692444]
Agonist activity at AR expressed in african green monkey CV-1 cells by luciferase reporter assay relative to control [AID433772, Type: Literature]
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25
[SID103692444]
Agonist activity at MR expressed in african green monkey CV-1 cells by luciferase reporter assay relative to control [AID433773, Type: Literature]
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26
[SID103692444]
Antagonist activity at GR expressed in human A549 cell line relative to control [AID433774, Type: Literature]
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27
[SID103692444]
Selectivity, ratio for IC50 for AR to IC50 for PR [AID455830, Type: Literature]
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28
[SID103692444]
Plasma clearance in rat at 1.1 mg/kg, iv [AID455835, Type: Literature]
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29
[SID103692444]
Volume of distribution at steady state in rat at 1.1 mg/kg, iv and 2.1 mg/kg po [AID455836, Type: Literature]
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30
[SID103692444]
Cmax in rat at 1.1 mg/kg, iv [AID455837, Type: Literature]
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31
[SID103692444]
Half life in rat at 1.1 mg/kg, iv [AID455838, Type: Literature]
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32
[SID103692444]
Oral bioavailability in rat at 2.1 mg/kg [AID455839, Type: Literature]
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33
[SID103692444]
Agonist activity at PR in human T47D cells relative to progesterone [AID455832, Type: Literature]Progesterone receptor [gi:90110048]
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34
[SID103692444]
Agonist activity at GR [AID433775, Type: Literature]
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