MLS002174364 (CID 16656441) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(346)
 
 
Inconclusive(11)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
7TM GPCR Srsx(6)
 
 
Peptidase C48(4)
 
 
alkPPc(4)
 
 
BRLZ(3)
 
 
BioAssay Types:
Screening(263)
 
 
 
 
Confirmatory(95)
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(82)
 
 
 
 
IC50(11)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 367    Data Row: 367   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56463384]
 Fluorescence-based biochemical high throughput confirmation assay to identify molecules that bind r(CAG) RNA repeats [AID652065, Type: screening]
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2
[SID56463384]
 Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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3
[SID56463384]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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4
[SID56463384]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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5
[SID56463384]
 Counterscreen for molecules that bind rCAG RNA repeats: fluorescent based biochemical counterscreen assay for inhibitors of the DNA-based (5'CAG/3'GTC) TO-PRO-1 dye complex [AID652068, Type: screening]
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6
[SID56463384]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2) [AID492953, Type: screening]platelet-activating factor acetylhydrolase IB subunit beta isoform b [Homo sapiens] [gi:296080766]
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7
[SID56463384]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2) [AID493034, Type: screening]platelet-activating factor acetylhydrolase IB subunit beta isoform b [Homo sapiens] [gi:296080766]
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8
[SID56463384]
 Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1). [AID2235, Type: screening]PPP1CA gene product [Homo sapiens] [gi:56790945]
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9
[SID56463384]
 Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) [AID588511, Type: screening]Ano1 gene product [Mus musculus] [gi:334278898]
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10
[SID56463384]
 In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_Activity [AID504582, Type: screening]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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11
[SID56463384]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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12
[SID56463384]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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13
[SID56463384]
Potency 11.2202qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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14
[SID56463384]
Potency 11.2202qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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15
[SID56463384]
Potency 18.526Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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16
[SID56463384]
Potency 35.4813qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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17
[SID56463384]
Potency 35.4813qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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18
[SID56463384]
 Fluorescence-based biochemical primary high throughput assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID651800, Type: screening]TCRAV4S1 [Homo sapiens] [gi:2358024]
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19
[SID56463384]
 Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]NR2F2 gene product [Homo sapiens] [gi:14149746]
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20
[SID56463384]
 Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]NR2F2 gene product [Homo sapiens] [gi:14149746]
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21
[SID56463384]
Potency qHTS assay for re-activators of p53 using a Luc reporter [AID504706, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
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22
[SID56463384]
Potency qHTS assay for re-activators of p53 using a Luc reporter [AID504706, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
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23
[SID56463384]
Potency qHTS assay for re-activators of p53 using a Luc reporter [AID504706, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
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24
[SID56463384]
Potency qHTS assay for re-activators of p53 using a Luc reporter [AID504706, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
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25
[SID56463384]
 qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Primary Screen for Agonists. [AID493084, Type: screening]thyrotropin-releasing hormone receptor [Homo sapiens] [gi:4507681]
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26
[SID56463384]
 qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Primary Screen for Enhancers [AID493056, Type: screening]thyrotropin-releasing hormone receptor [Homo sapiens] [gi:4507681]
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27
[SID56463384]
Potency qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101 [AID493005, Type: confirmatory]TSG101 gene product [Homo sapiens] [gi:5454140]
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28
[SID56463384]
Potency qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101 [AID493005, Type: confirmatory]TSG101 gene product [Homo sapiens] [gi:5454140]
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29
[SID56463384]
 Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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30
[SID56463384]
 Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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31
[SID56463384]
 Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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32
[SID56463384]
 Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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33
[SID56463384]
 Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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34
[SID56463384]
 Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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35
[SID56463384]
 uHTS identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID485273, Type: screening]UBE2N gene product [Homo sapiens] [gi:4507793]
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36
[SID56463384]
 uHTS identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID485273, Type: screening]UBE2N gene product [Homo sapiens] [gi:4507793]
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37
[SID56463384]
 uHTS identification of SUMO1-mediated protein-protein interactions [AID602429, Type: screening]SUMO-1 [Homo sapiens] [gi:1762973]
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38
[SID56463384]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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39
[SID56463384]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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40
[SID56463384]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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41
[SID56463384]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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42
[SID56463384]
 HTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1 [AID540275, Type: screening]TRPV1 gene product [Homo sapiens] [gi:74315350]
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43
[SID56463384]
 HTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1 [AID540275, Type: screening]TRPV1 gene product [Homo sapiens] [gi:74315350]
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44
[SID56463384]
Potency qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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45
[SID56463384]
 HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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46
[SID56463384]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]PLA2G7 gene product [Homo sapiens] [gi:270133071]
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47
[SID56463384]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]PLA2G7 gene product [Homo sapiens] [gi:270133071]
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48
[SID56463384]
 Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3) [AID588352, Type: screening]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
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49
[SID56463384]
 Identification of inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_SinglePoint_HTS_Activity [AID602329, Type: screening]RAD54L gene product [Homo sapiens] [gi:216548193]
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50
[SID56463384]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the Galanin Receptor 3 (GalR3) [AID651719, Type: screening]GALR3 gene product [Homo sapiens] [gi:4503907]
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