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MLS001077468 (CID 16546000) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(456)
 
 
Inconclusive(10)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
7TM GPCR Srsx(15)
 
 
CAP ED(5)
 
 
TRP 2(5)
 
 
Troponin(4)
 
 
BioAssay Types:
Screening(345)
 
 
 
 
Confirmatory(114)
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(101)
 
 
 
 
IC50(11)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 432    Data Row: 468   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56315236]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Escherichia coli DNA-binding ATP-dependent protease La (eLon) [AID602123, Type: screening]DNA-binding ATP-dependent protease La [Escherichia coli str. K-12 substr. MG1655] [gi:16128424]
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2
[SID56315236]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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3
[SID56315236]
Potency 0.631Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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4
[SID56315236]
Potency 0.8913qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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5
[SID56315236]
Potency 35.4813qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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6
[SID56315236]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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7
[SID56315236]
Full deck counterscreen for positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602247, Type: screening]
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8
[SID56315236]
Full deck counterscreen for agonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602248, Type: screening]
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9
[SID56315236]
Full deck counterscreen for antagonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective inhibitors and assay artifacts using the parental CHOK1 cell line [AID602250, Type: screening]
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10
[SID56315236]
uHTS luminescent assay for identification of compounds that enhance the survival of human induced pluripotent stem cells when cultured as single cells [AID602274, Type: screening]
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11
[SID56315236]
HTS for suppressors of simvastatin-induced mytoxicity in differentiated C2C12 cells Measured in Cell-Based System Using Plate Reader - 2112-01_Suppressor_SinglePoint_HTS_Activity [AID602340, Type: screening]
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12
[SID56315236]
Whole cell Yeast HTS to identify compounds modulating the fidelity of the start codon recognition in eukaryotes. Measured in Whole Organism System Using Plate Reader - 2155-01_Other_SinglePoint_HTS_Activity [AID602363, Type: screening]
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13
[SID56315236]
uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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14
[SID56315236]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening] [geneid:2395]
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15
[SID56315236]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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16
[SID56315236]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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17
[SID56315236]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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18
[SID56315236]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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19
[SID56315236]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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20
[SID56315236]
Potency qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
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21
[SID56315236]
Potency qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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22
[SID56315236]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN. [AID2029, Type: screening]citrate synthase 2, partial [Saccharomyces cerevisiae] [gi:171229]
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23
[SID56315236]
Potency Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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24
[SID56315236]
Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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25
[SID56315236]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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26
[SID56315236]
7011-01_Antagonist_SinglePoint_HTS_Activity [AID720647, Type: screening]
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27
[SID56315236]
HTS for Bacterial rRNA inhibitors Measured in Microorganism-Based System Using Plate Reader - 7056-01_Inhibitor_SinglePoint_HTS_Activity [AID720706, Type: screening]
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28
[SID56315236]
High Content Cell-Based Imaging Primary HTS to Identify Small Molecules Involved in X-Chromosome Reactivation and Reprogramming Measured in Cell-Based System Using Imaging - 7015-01_Activator_SinglePoint_HTS_Activity_Set2 [AID743238, Type: screening]
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29
[SID56315236]
Inhibition of Alexa 488-Fibronectin deposition #on AH1F cell monolayers Measured in Cell-Based System Using Plate Reader - 7059-01_Inhibitor_SinglePoint_HTS_Activity [AID743247, Type: screening]
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30
[SID56315236]
Luminescent GLuc Reporter Gene Assay Primary HTS to Identify Small Molecule Activator of Glucose Dependent Insulin Secretion Measured in Cell-Based System Using Plate Reader - 7055-01_Activator_SinglePoint_HTS_Activity [AID743287, Type: screening]
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31
[SID56315236]
HTS for Inhibition of CaV1.3 ICDI/IQ interaction using a live-cell FRET assay Measured in Cell-Based System Using Plate Reader - 7081-01_Inhibitor_SinglePoint_HTS_Activity [AID743397, Type: screening]
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32
[SID56315236]
Wnt/Beta-catenin HTS Measured in Cell-Based System Using Plate Reader - 2161-01_Activator_SinglePoint_HTS_Activity [AID743398, Type: screening]
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33
[SID56315236]
MLPCN Ras selective lethality-BJeLR viability [AID1554, Type: screening]
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34
[SID56315236]
MLPCN Platelet Activation -Dense Granule Release [AID1663, Type: screening]
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35
[SID56315236]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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36
[SID56315236]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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37
[SID56315236]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Polyadenylation [AID1875, Type: screening]
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38
[SID56315236]
Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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39
[SID56315236]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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40
[SID56315236]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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41
[SID56315236]
Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID1910, Type: screening]
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42
[SID56315236]
Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 Activity [AID2099, Type: screening]
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43
[SID56315236]
Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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44
[SID56315236]
uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line [AID2380, Type: screening]
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45
[SID56315236]
IC50 A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) [AID2391, Type: confirmatory]
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46
[SID56315236]
A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide [AID2690, Type: screening]
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47
[SID56315236]
Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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48
[SID56315236]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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49
[SID56315236]
IC90 Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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50
[SID56315236]
uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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