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MLS000551326 (CID 16409855) - Compound BioActivity Data
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BioActivity Outcomes:
Active(82)
 
 
Inactive(662)
 
 
Inconclusive(33)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(19)
 
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
Tryp SPc(9)
 
 
BioAssay Types:
Screening(532)
 
 
 
 
 
Confirmatory(231)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(151)
 
 
 
 
 
IC50(51)
 
 
 
 
EC50(19)
 
 
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 708    Data Row: 780   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14743207]
AC50_uM 0.195Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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2
[SID14743207]
EC50_uM 0.615Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast [AID2631, Type: confirmatory]
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3
[SID14743207]
EC50_uM 0.8556Fluorescent Cell-Based Secondary Screen to Identify Activators of the Hypoxia Factor Pathway [AID434951, Type: confirmatory]
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4
[SID14743207]
Potency 0.92qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID14743207]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID14743207]
Potency 1.6511Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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7
[SID14743207]
AC50_uM 1.78ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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8
[SID14743207]
Potency 2.5929qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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9
[SID14743207]
EC50 3.437Luminescence Cell-Based Confirmation at Dose to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID2089, Type: confirmatory]
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10
[SID14743207]
Potency 3.6626qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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11
[SID14743207]
EC50 3.684Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast [AID1936, Type: confirmatory]
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12
[SID14743207]
Potency 3.9811qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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13
[SID14743207]
EC50 4.086Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast [AID1933, Type: confirmatory]
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14
[SID14743207]
EC50 4.215Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast [AID1935, Type: confirmatory]
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15
[SID14743207]
Potency 4.2562qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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16
[SID14743207]
Potency 4.4668qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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17
[SID14743207]
Potency 4.4668qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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18
[SID14743207]
Potency 4.4668qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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19
[SID14743207]
Potency 5.0119qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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20
[SID14743207]
Potency 5.0119VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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21
[SID14743207]
IC50 5.64A High Throughput Confirmatory Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in the absence of Glycerol [AID449764, Type: confirmatory]
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22
[SID14743207]
EC50 5.67Luminescent Cell-Based Dose Titration Retest Counterscreen to Identify Proteasome Inhibitors [AID2486, Type: confirmatory]
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23
[SID14743207]
EC50 5.722Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to DRD Non-Viral Oncogenic Fibroblast [AID1934, Type: confirmatory]
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24
[SID14743207]
IC50 5.91High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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25
[SID14743207]
CC50 6.391A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Mycobacterium Tuberculosis [AID435019, Type: confirmatory]
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26
[SID14743207]
Potency 7.0795qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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27
[SID14743207]
Potency 7.9053qHTS Assay for Inhibitors of Hepatitis C Virus (HCV): Confirmation Assay for Cherry-picked Compounds [AID720575, Type: confirmatory]hepatitis C virus polyprotein [Hepatitis C virus] [gi:295901482]
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28
[SID14743207]
Potency 8.9125Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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29
[SID14743207]
Potency 11.1666qHTS Assay for Inhibitors of Hepatitis C Virus (HCV): Cytotoxicity Counterscreen for Cherry-picked Compounds [AID720576, Type: confirmatory]
View
30
[SID14743207]
Potency 14.1254qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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31
[SID14743207]
Potency 15.8489HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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32
[SID14743207]
Potency 28.1838qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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33
[SID14743207]
uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin-1 [gi:160877737]
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34
[SID14743207]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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35
[SID14743207]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID540248, Type: other]HTRA1 protein [gi:121945198]
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36
[SID14743207]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
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37
[SID14743207]
Fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of alpha/beta hydrolase domain containing 4 (ABHD4). [AID720658, Type: screening]abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] [gi:326937491]
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38
[SID14743207]
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of alpha/beta hydrolase domain containing 4 (ABHD4). [AID720543, Type: screening]abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] [gi:326937491]
View
39
[SID14743207]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]BRCA1-associated RING domain protein 1 [gi:116241265]
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40
[SID14743207]
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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41
[SID14743207]
Human Endothelial Cell Proliferation Assay in 384-well format [AID648, Type: screening]
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42
[SID14743207]
Leishmania major promastigote HTS [AID1063, Type: screening]
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43
[SID14743207]
Counter Screen for Luciferase-based Primary Inhibition Assays [AID1006, Type: screening]
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44
[SID14743207]
Identification of compounds which are cytotoxic to PPC-1 cells. [AID1447, Type: screening]
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45
[SID14743207]
MLPCN Ras selective lethality-BJeLR viability [AID1554, Type: screening]
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46
[SID14743207]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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47
[SID14743207]
Human Lung Fibroblast Proliferation Assay [AID719, Type: screening]
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48
[SID14743207]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
View
49
[SID14743207]
SAMPLE2_EC50_uM Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJeLR Fibroblast [AID2610, Type: confirmatory]
View
50
[SID14743207]
Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID1910, Type: screening]
View